PMID- 26791010
OWN - NLM
STAT- MEDLINE
DCOM- 20170807
LR  - 20220311
IS  - 1348-4214 (Electronic)
IS  - 0916-9636 (Linking)
VI  - 39
IP  - 5
DP  - 2016 May
TI  - Abdominal obesity and hypertension: a double burden to the heart.
PG  - 349-55
LID - 10.1038/hr.2015.145 [doi]
AB  - Abdominal obesity (AO) is strongly associated with increased cardiovascular risk 
      in hypertensives. Visceral adipose tissue has an important part in water 
      retention, the sympathetic nervous system and renin-angiotensin-aldosterone 
      system activation, which may influence central and systemic hemodynamics. The aim 
      of this study was to estimate the relationship between AO and the hemodynamic 
      profile of patients with arterial hypertension (AH). The clinical evaluation of 
      144 hypertensives included the following: (1) echocardiographic assessment of the 
      left ventricular ejection fraction (LVEF), the global longitudinal systolic 
      strain (GLSS) and diastolic function (E/A-phase ratio of mitral flow early (E) 
      and late (A) and E/e'-ratio of early mitral flow and mitral septal annulus early 
      diastolic velocity (e')); (2) the applanation tonometry including the central 
      pulse pressure (CPP) and augmentation index (AI); and (3) the impedance 
      cardiography, acceleration index (ACI), velocity index (VI), systemic vascular 
      resistance index (SVRI) and total artery compliance (TAC). Obese hypertensives in 
      comparison with non-obese ones were characterized with the following values: (1) 
      lower echocardiographic (GLSS: -17.2+/-2.5% vs. -19.0+/-2.8%, P=0.0002) and impedance 
      indices of left ventricular performance (VI: 44.8+/-12.4 vs. 51.6+/-14.2 x 
      1000*Omega* s(-1), P=0.006; ACI: 66.7+/-27.8 vs. 79.1+/-31.2 100*Omega* s(-)(2), P=0.003) and 
      (2) worse diastolic function (e': 9.08+/-2.69 vs. 10.39+/-2.34 cm*s(-1), P=0.003; 
      E/e': 7.54+/-1.81 vs. 6.74+/-1.40, P=0.007; E/A: 1.02+/-0.34 vs. 1.15+/-0.33, P=0.008). 
      No relevant differences for gender, age, blood pressure, heart rate, LVEF, SVRI, 
      TAC, CPP and AI were identified. AH and AO have overlapping effects on 
      cardiovascular hemodynamics. At the early asymptomatic stage, this overlap is 
      exhibited in the impaired cardiac function.
FAU - Krzesinski, Pawel
AU  - Krzesinski P
AD  - Department of Cardiology and Internal Diseases, Military Institute of Medicine, 
      Warsaw, Poland.
FAU - Stanczyk, Adam
AU  - Stanczyk A
AD  - Department of Cardiology and Internal Diseases, Military Institute of Medicine, 
      Warsaw, Poland.
FAU - Piotrowicz, Katarzyna
AU  - Piotrowicz K
AD  - Department of Cardiology and Internal Diseases, Military Institute of Medicine, 
      Warsaw, Poland.
FAU - Gielerak, Grzegorz
AU  - Gielerak G
AD  - Department of Cardiology and Internal Diseases, Military Institute of Medicine, 
      Warsaw, Poland.
FAU - Uzieblo-Zyczkowska, Beata
AU  - Uzieblo-Zyczkowska B
AD  - Department of Cardiology and Internal Diseases, Military Institute of Medicine, 
      Warsaw, Poland.
FAU - Skrobowski, Andrzej
AU  - Skrobowski A
AD  - Department of Cardiology and Internal Diseases, Military Institute of Medicine, 
      Warsaw, Poland.
LA  - eng
PT  - Journal Article
DEP - 20160121
PL  - England
TA  - Hypertens Res
JT  - Hypertension research : official journal of the Japanese Society of Hypertension
JID - 9307690
SB  - IM
CIN - Hypertens Res. 2016 May;39(5):293-4. PMID: 26888121
MH  - Adult
MH  - Blood Pressure/physiology
MH  - Echocardiography
MH  - Female
MH  - Heart/*physiopathology
MH  - Hemodynamics/physiology
MH  - Humans
MH  - Hypertension/complications/diagnostic imaging/*physiopathology
MH  - Male
MH  - Middle Aged
MH  - Obesity, Abdominal/complications/diagnostic imaging/*physiopathology
MH  - Risk Factors
MH  - Stroke Volume
MH  - Vascular Resistance/physiology
MH  - Ventricular Function, Left/*physiology
EDAT- 2016/01/23 06:00
MHDA- 2017/08/08 06:00
CRDT- 2016/01/22 06:00
PHST- 2015/04/29 00:00 [received]
PHST- 2015/09/02 00:00 [revised]
PHST- 2015/11/05 00:00 [accepted]
PHST- 2016/01/22 06:00 [entrez]
PHST- 2016/01/23 06:00 [pubmed]
PHST- 2017/08/08 06:00 [medline]
AID - hr2015145 [pii]
AID - 10.1038/hr.2015.145 [doi]
PST - ppublish
SO  - Hypertens Res. 2016 May;39(5):349-55. doi: 10.1038/hr.2015.145. Epub 2016 Jan 21.