PMID- 26791860
OWN - NLM
STAT- MEDLINE
DCOM- 20161028
LR  - 20161230
IS  - 1557-8445 (Electronic)
IS  - 0065-2776 (Linking)
VI  - 129
DP  - 2016
TI  - Gene Map of the HLA Region, Graves' Disease and Hashimoto Thyroiditis, and 
      Hematopoietic Stem Cell Transplantation.
PG  - 175-249
LID - S0065-2776(15)00054-1 [pii]
LID - 10.1016/bs.ai.2015.08.003 [doi]
AB  - The human leukocyte antigen (HLA) genomic region spanning about 4 Mb is the most 
      gene dense and the polymorphic stretches in the human genome. A total of the 269 
      loci were identified, including 145 protein coding genes mostly important for 
      immunity and 50 noncoding RNAs (ncRNAs). Biological function of these ncRNAs 
      remains unknown, becoming hot spot in the studies of HLA-associated diseases. The 
      genomic diversity analysis in the HLA region facilitated by next-generation 
      sequencing will pave the way to molecular understanding of linkage disequilibrium 
      structure, population diversity, histocompatibility in transplantation, and 
      associations with autoimmune diseases. The 4-digit DNA genotyping of HLA for six 
      HLA loci, HLA-A through DP, in the patients with Graves' disease (GD) and 
      Hashimoto thyroiditis (HT) identified six susceptible and three resistant HLA 
      alleles. Their epistatic interactions in controlling the development of these 
      diseases are shown. Four susceptible and one resistant HLA alleles are shared by 
      GD and HT. Two HLA alleles associated with GD or HT control the titers of 
      autoantibodies to thyroid antigens. All these observations led us to propose a 
      new model for the development of GD and HT. Hematopoietic stem cell 
      transplantation from unrelated donor (UR-HSCT) provides a natural experiment to 
      elucidate the role of allogenic HLA molecules in immune response. Large cohort 
      studies using HLA allele and clinical outcome data have elucidated that (1) HLA 
      locus, allele, and haplotype mismatches between donor and patient, (2) specific 
      amino acid substitution at specific positions of HLA molecules, and (3) ethnic 
      background are all responsible for the immunological events related to UR-HSCT 
      including acute graft-versus-host disease (GVHD), chronic GVHD, 
      graft-versus-leukemia (GvL) effect, and graft failure.
CI  - (c) 2016 Elsevier Inc. All rights reserved.
FAU - Sasazuki, Takehiko
AU  - Sasazuki T
AD  - Institute for Advanced Study, Kyushu University, Higashi-ku, Fukuoka, Japan. 
      Electronic address: sasazuki@bioreg.kyushu-u.ac.jp.
FAU - Inoko, Hidetoshi
AU  - Inoko H
AD  - GenoDive Pharma Inc., Atsugi, Kanagawa, Japan.
FAU - Morishima, Satoko
AU  - Morishima S
AD  - Division of Hematology, Fujita Health University School of Medicine, Toyoake, 
      Aichi, Japan.
FAU - Morishima, Yasuo
AU  - Morishima Y
AD  - Division of Epidemiology and Prevention, Aiichi Cancer Center Research Institute, 
      Chikusa-ku, Nagoya, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20151201
PL  - United States
TA  - Adv Immunol
JT  - Advances in immunology
JID - 0370425
RN  - 0 (Autoantibodies)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Alleles
MH  - Autoantibodies/blood/genetics/immunology
MH  - *Chromosome Mapping
MH  - Epistasis, Genetic
MH  - Genetic Predisposition to Disease
MH  - Genetic Variation
MH  - Graft vs Host Disease/genetics
MH  - Graft vs Leukemia Effect/genetics/immunology
MH  - Graves Disease/*genetics
MH  - Haplotypes
MH  - Hashimoto Disease/*genetics
MH  - *Hematopoietic Stem Cell Transplantation
MH  - High-Throughput Nucleotide Sequencing
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Histocompatibility Antigens Class II/*genetics
MH  - Humans
OTO - NOTNLM
OT  - Acute graft-versus-host disease
OT  - DNA typing
OT  - Epistatic interaction
OT  - Genome diversity
OT  - Graft-versus-leukemia effect
OT  - Graves' disease
OT  - HLA allele
OT  - HLA class I and class II gene and molecule
OT  - HLA haplotype
OT  - Hashimoto thyroiditis
OT  - Linkage disequilibrium
OT  - Next-generation sequencing
OT  - Polymorphism
OT  - Regulatory T cell
OT  - Thyroglobulin antibody and serum level
OT  - Thyroid peroxidase antibody and serum level
OT  - Thyroid stimulating hormone receptor antibody and serum level
OT  - Unrelated hematopoietic stem cell transplantation
EDAT- 2016/01/23 06:00
MHDA- 2016/11/01 06:00
CRDT- 2016/01/22 06:00
PHST- 2016/01/22 06:00 [entrez]
PHST- 2016/01/23 06:00 [pubmed]
PHST- 2016/11/01 06:00 [medline]
AID - S0065-2776(15)00054-1 [pii]
AID - 10.1016/bs.ai.2015.08.003 [doi]
PST - ppublish
SO  - Adv Immunol. 2016;129:175-249. doi: 10.1016/bs.ai.2015.08.003. Epub 2015 Dec 1.