PMID- 26792296 OWN - NLM STAT- MEDLINE DCOM- 20161213 LR - 20161230 IS - 1573-2509 (Electronic) IS - 0920-9964 (Linking) VI - 170 IP - 2-3 DP - 2016 Feb TI - Association between rostral prefrontal cortical activity and functional outcome in first-episode psychosis: a longitudinal functional near-infrared spectroscopy study. PG - 304-10 LID - S0920-9964(16)30006-8 [pii] LID - 10.1016/j.schres.2016.01.003 [doi] AB - BACKGROUND: Few biomarkers can be used easily and noninvasively to measure clinical condition and future outcome in patients with first-episode psychosis (FEP). To develop such biomarker using multichannel functional near-infrared spectroscopy (fNIRS), cortical function in the prefrontal cortex was longitudinally measured during a verbal fluency task. METHODS: Sixty-nine fNIRS measurements and 77 clinical assessments were obtained from 31 patients with FEP at baseline, 6-month, and 12-month follow-ups. Sixty measurements were obtained from 30 healthy controls matched for age, sex, and premorbid IQ. We initially tested signal changes for 12 months, and then investigated the relationship between fNIRS signals and clinical assessments. RESULTS: Signal changes from baseline to 12-month follow-up were not evident in any group. Patients with FEP had significant positive correlation coefficients between 6-month fNIRS signals and the 12-month Global Assessment of Functioning (GAF) score in the left middle frontal gyrus (FDR-corrected p=.0016-.0052, r=.65-.59). fNIRS signals at the 12-month follow-up were associated with 12-month GAF score in the bilateral superior and middle frontal gyri (FDR-corrected p=.00085-.018, r=.72-.55), and with the difference between baseline and 12-month GAF scores in the right superior frontal gyrus (FDR-corrected p=.000067-.00012, r=.80-.78). These associations were significant even after controlling for demographic variables. No association between baseline fNIRS signals and later GAF scores was found. DISCUSSION: fNIRS measurement can potentially be used as a biomarker to aid sequential assessment of neuro-clinical conditions through the early stage of psychosis. CI - Copyright (c) 2016 Elsevier B.V. All rights reserved. FAU - Koike, Shinsuke AU - Koike S AD - Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan; Office for Mental Health Support, Division for Counseling and Support, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. Electronic address: skoike-tky@umin.ac.jp. FAU - Satomura, Yoshihiro AU - Satomura Y AD - Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. FAU - Kawasaki, Shingo AU - Kawasaki S AD - Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan; Application Development Office, Hitachi Medical Corporation, 2-1 Shintoyofuta, Kashiwa City, Chiba 277-0804, Japan. FAU - Nishimura, Yukika AU - Nishimura Y AD - Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. FAU - Takano, Yosuke AU - Takano Y AD - Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. FAU - Iwashiro, Norichika AU - Iwashiro N AD - Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. FAU - Kinoshita, Akihide AU - Kinoshita A AD - Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. FAU - Nagai, Tatsuya AU - Nagai T AD - Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. FAU - Natsubori, Tatsunobu AU - Natsubori T AD - Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. FAU - Tada, Mariko AU - Tada M AD - Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. FAU - Ichikawa, Eriko AU - Ichikawa E AD - Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. FAU - Takizawa, Ryu AU - Takizawa R AD - Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, 16 De Crespigny Park, London SE5 8AF, UK. FAU - Kasai, Kiyoto AU - Kasai K AD - Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan; JST, National Bioscience Database Center (NBDC), 5-3 Yonbancho, Chiyoda-ku, Tokyo 102-8666, Japan. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20160111 PL - Netherlands TA - Schizophr Res JT - Schizophrenia research JID - 8804207 RN - 0 (Antipsychotic Agents) SB - IM MH - Acute Disease MH - Adult MH - Antipsychotic Agents/therapeutic use MH - Cerebrovascular Circulation/drug effects/physiology MH - Cross-Sectional Studies MH - Female MH - Follow-Up Studies MH - Humans MH - Longitudinal Studies MH - Male MH - Multivariate Analysis MH - Neuropsychological Tests MH - Prefrontal Cortex/drug effects/*physiopathology MH - Psychiatric Status Rating Scales MH - Psychotic Disorders/*diagnosis/drug therapy/*physiopathology MH - Regression Analysis MH - Schizophrenia/*diagnosis/drug therapy/*physiopathology MH - *Spectroscopy, Near-Infrared MH - Treatment Outcome MH - Young Adult OTO - NOTNLM OT - Biological markers OT - Clinical outcome OT - Early intervention OT - First-episode schizophrenia OT - Functional near-infrared spectroscopy (fNIRS) OT - Functional neuroimaging EDAT- 2016/01/23 06:00 MHDA- 2016/12/15 06:00 CRDT- 2016/01/22 06:00 PHST- 2015/09/18 00:00 [received] PHST- 2015/12/24 00:00 [revised] PHST- 2016/01/01 00:00 [accepted] PHST- 2016/01/22 06:00 [entrez] PHST- 2016/01/23 06:00 [pubmed] PHST- 2016/12/15 06:00 [medline] AID - S0920-9964(16)30006-8 [pii] AID - 10.1016/j.schres.2016.01.003 [doi] PST - ppublish SO - Schizophr Res. 2016 Feb;170(2-3):304-10. doi: 10.1016/j.schres.2016.01.003. Epub 2016 Jan 11.