PMID- 26792456
OWN - NLM
STAT- MEDLINE
DCOM- 20171016
LR  - 20171016
IS  - 1878-7533 (Electronic)
IS  - 1550-7289 (Linking)
VI  - 12
IP  - 3
DP  - 2016 Mar-Apr
TI  - Impact of sleeve gastrectomy on gastroesophageal reflux disease in a morbidly 
      obese population undergoing bariatric surgery.
PG  - 511-517
LID - S1550-7289(15)00814-X [pii]
LID - 10.1016/j.soard.2015.08.507 [doi]
AB  - BACKGROUND: Laparoscopic sleeve gastrectomy (LSG) has established popularity as a 
      weight loss procedure based on its success. However, LSG's effect on 
      gastroesophageal reflux disease (GERD) is unknown. OBJECTIVES: To analyze the 
      incidence of GERD after LSG and to compare the results in patients with 
      preexisting and de novo GERD. SETTING: Tertiary Medical center. METHODS: The 
      authors performed a retrospective review of primary LSG from 2005 to 2013 and 
      compared patients with pre-existing and de novo GERD who underwent LSG. RESULTS: 
      A total of 919 patients underwent LSG. GERD was present in 38 (4%) of the LSG 
      cohort. We identified 2 groups: Group A consisted of 25 (3%) patients with de 
      novo GERD, and Group B consisted of 13 (1%) patients with pre-existing GERD. 
      Diagnosis of GERD in both groups was determined by symptoms and history of proton 
      pump inhibitor (PPI) treatment, upper gastrointestinal endoscopy, 
      esophagogastroduodenoscopy, and pH manometry. In Group A, 1 (4%) patient was 
      managed with over-the-counter drugs, 17 (68%) patients were treated with low-dose 
      PPI, 6 (24%) patients were treated with high-dose PPI, and 1 (4%) patient was 
      lost to follow-up. Group B consisted of 9 (69%) patients treated with low-dose 
      PPI and 4 (31%) patients treated with high-dose PPI. Medical treatment failed in 
      4 patients (10.5%) who subsequently required conversion to laparoscopic Roux-en-Y 
      gastric bypass (LRYGB). In Group A, 1 patient (4%) required LRYGB, and in Group 
      B, 3 patients (23%) required LRYGB. The outcome of conversion for Group A was 
      incomplete resolution of symptoms in the 1 patient, whereas in Group B, all 3 
      patients (100%) had complete resolution of GERD symptoms after LRYGB. 
      CONCLUSIONS: In this study, 3% of patients developed de novo GERD, but most 
      responded to either low- or high-dose PPI, with 4% requiring conversion to LRYGB.
CI  - Copyright (c) 2016 American Society for Metabolic and Bariatric Surgery. Published 
      by Elsevier Inc. All rights reserved.
FAU - Hendricks, LeShon
AU  - Hendricks L
AD  - The Bariatric & Metabolic Institute, Section of Minimally Invasive Surgery, 
      Department of General Surgery, Cleveland Clinic Florida, Weston, Florida.
FAU - Alvarenga, Emanuela
AU  - Alvarenga E
AD  - The Bariatric & Metabolic Institute, Section of Minimally Invasive Surgery, 
      Department of General Surgery, Cleveland Clinic Florida, Weston, Florida.
FAU - Dhanabalsamy, Nisha
AU  - Dhanabalsamy N
AD  - The Bariatric & Metabolic Institute, Section of Minimally Invasive Surgery, 
      Department of General Surgery, Cleveland Clinic Florida, Weston, Florida.
FAU - Lo Menzo, Emanuele
AU  - Lo Menzo E
AD  - The Bariatric & Metabolic Institute, Section of Minimally Invasive Surgery, 
      Department of General Surgery, Cleveland Clinic Florida, Weston, Florida.
FAU - Szomstein, Samuel
AU  - Szomstein S
AD  - The Bariatric & Metabolic Institute, Section of Minimally Invasive Surgery, 
      Department of General Surgery, Cleveland Clinic Florida, Weston, Florida.
FAU - Rosenthal, Raul
AU  - Rosenthal R
AD  - The Bariatric & Metabolic Institute, Section of Minimally Invasive Surgery, 
      Department of General Surgery, Cleveland Clinic Florida, Weston, Florida. 
      Electronic address: Rosentr@ccf.org.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20151001
PL  - United States
TA  - Surg Obes Relat Dis
JT  - Surgery for obesity and related diseases : official journal of the American 
      Society for Bariatric Surgery
JID - 101233161
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Endoscopy, Digestive System
MH  - Endoscopy, Gastrointestinal
MH  - Gastrectomy/*adverse effects
MH  - Gastric Bypass/methods
MH  - Gastroesophageal Reflux/drug therapy/*etiology
MH  - Hernia, Hiatal/surgery
MH  - Humans
MH  - Laparoscopy/*adverse effects
MH  - Manometry
MH  - Obesity, Morbid/*surgery
MH  - Postoperative Complications/etiology
MH  - Proton Pump Inhibitors/administration & dosage
MH  - Reoperation
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Gastrectomy
OT  - Gastroesophageal
OT  - Gastroesophageal reflux disease
OT  - Reflux
OT  - Sleeve
EDAT- 2016/01/23 06:00
MHDA- 2017/10/17 06:00
CRDT- 2016/01/22 06:00
PHST- 2015/05/07 00:00 [received]
PHST- 2015/07/27 00:00 [revised]
PHST- 2015/08/24 00:00 [accepted]
PHST- 2016/01/22 06:00 [entrez]
PHST- 2016/01/23 06:00 [pubmed]
PHST- 2017/10/17 06:00 [medline]
AID - S1550-7289(15)00814-X [pii]
AID - 10.1016/j.soard.2015.08.507 [doi]
PST - ppublish
SO  - Surg Obes Relat Dis. 2016 Mar-Apr;12(3):511-517. doi: 
      10.1016/j.soard.2015.08.507. Epub 2015 Oct 1.