PMID- 2679274
OWN - NLM
STAT- MEDLINE
DCOM- 19891109
LR  - 20191210
IS  - 0302-4342 (Print)
IS  - 0302-4342 (Linking)
VI  - 30
IP  - 6
DP  - 1989 Jun
TI  - [Evaluation of the inflammatory and nutritional status in children with cystic 
      fibrosis].
PG  - 447-50
AB  - The authors present a system for the appraisal of the nutritional and 
      inflammatory condition in patients suffering from cystic fibrosis (CF) in the 
      phase of apparent inactivity of pulmonary infection, using a system of indices 
      based on the quantification of some plasmatic proteins. The plasmatic appraisals 
      of 4 visceral proteins (albumin, thyroxine-binding prealbumin, retinol-binding 
      protein and transferrin) and, as well, of 5 proteins of the acute phase 
      (alpha-1-acid glycoprotein, alpha-1-antitrypsin, alpha-2-macroglobulin, 
      haptoglobin and ceruloplasmin) were obtained in a control group of 16 healthy 
      children and in another of 14 children affected by CF. With the proteic plasmatic 
      appraisals of the control group, the knowledge of their biological value and 
      after a statistical-mathematical analysis, the most sensitive, specific and 
      independent proteins were determined for evaluating the nutritional and 
      inflammatory condition, obtaining two simple formulas which were denominated 
      Nutritional-Inflammatory Prognostic Indices (NIPI) A and B (NIPI A = alpha-1-acid 
      glycoprotein + haptoglobin/albumin + prealbumin; NIPI B = haptoglobin/albumin). 
      From the analysis of the results, it can be deduced that the children with CF are 
      affected by an inflammatory process, very probably infectious.
FAU - Sarria Chueca, A
AU  - Sarria Chueca A
AD  - Departamento de Pediatria, Facultad de Medicina, Universidad de Zaragoza.
FAU - Olivan Gonzalvo, G
AU  - Olivan Gonzalvo G
FAU - Lazaro Almarza, A
AU  - Lazaro Almarza A
FAU - Fleta Zaragozano, J
AU  - Fleta Zaragozano J
FAU - Tosao Sanchez, A
AU  - Tosao Sanchez A
FAU - Escanero Marcen, J F
AU  - Escanero Marcen JF
FAU - Elosegui Alberdi, L M
AU  - Elosegui Alberdi LM
FAU - Bueno Sanchez, M
AU  - Bueno Sanchez M
LA  - spa
PT  - Journal Article
TT  - Evaluacion del estado nutricional-inflamatorio en ninos afectos de fibrosis 
      quistica.
PL  - Spain
TA  - An Esp Pediatr
JT  - Anales espanoles de pediatria
JID - 0420463
RN  - 0 (Biomarkers)
RN  - 0 (Blood Proteins)
SB  - IM
MH  - Adolescent
MH  - Biomarkers/*blood
MH  - Blood Proteins/*analysis
MH  - Child
MH  - Child, Preschool
MH  - Cystic Fibrosis/*blood/complications/pathology
MH  - Female
MH  - Humans
MH  - Infections/complications
MH  - Inflammation
MH  - Male
MH  - Multivariate Analysis
MH  - Nutritional Status
MH  - Sensitivity and Specificity
EDAT- 1989/06/01 00:00
MHDA- 1989/06/01 00:01
CRDT- 1989/06/01 00:00
PHST- 1989/06/01 00:00 [pubmed]
PHST- 1989/06/01 00:01 [medline]
PHST- 1989/06/01 00:00 [entrez]
PST - ppublish
SO  - An Esp Pediatr. 1989 Jun;30(6):447-50.