PMID- 26793267
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160121
LR  - 20200930
IS  - 1744-859X (Print)
IS  - 1744-859X (Electronic)
IS  - 1744-859X (Linking)
VI  - 15
DP  - 2016
TI  - Utility of the Neurobehavioral Cognitive Status Examination (COGNISTAT) in 
      differentiating between depressive states in late-life depression and late-onset 
      Alzheimer's disease: a preliminary study.
PG  - 3
LID - 10.1186/s12991-016-0091-5 [doi]
LID - 3
AB  - BACKGROUND: It is often difficult to differentiate between the depressive states 
      seen in late-life depression and late-onset Alzheimer' disease (AD) in the 
      clinical setting. METHODS: Thirty-four outpatients were recruited, all fulfilling 
      the criteria of aged 65 years or above, scores of 14 or more on the Hamilton 
      depression rating scale (HAM-D), and 26 or less on the Mini-Mental State 
      Examination (MMSE). At the initial visit, they were administered the 
      Neurobehavioral Cognitive Status Examination (COGNISTAT). At 1 month, a diagnosis 
      of either senile depression (n = 24) or Alzheimer' disease (n = 10) was made. 
      RESULTS: The COGNISTAT revealed that the late-life depression group showed 
      significantly higher scores in orientation and comprehension subtests compared 
      with the AD group. At the study endpoint (6 months after treatment), MMSE 
      detected significant improvements in the late-life depression group (n = 15), but 
      no changes in the late-onset AD group (n = 7). Scores for memory, similarities, 
      and judgment on the second COGNISTAT were significantly improved in the depressed 
      group, whereas calculation scores deteriorated significantly in the AD group. 
      CONCLUSION: The COGNISTAT could prove useful in differentiating late-life 
      depression from late-onset AD, despite similar scores on MMSE.
FAU - Tsuruoka, Yoshiaki
AU  - Tsuruoka Y
AD  - Department of Psychiatry, Teikyo University Chiba Medical Center, 3426-3 Anesaki, 
      Ichihara, 299-0111 Japan ; Shirayurikai Otaki Hospital, 786 Uehara, Otaki, 
      298-0223 Japan.
FAU - Takahashi, Michio
AU  - Takahashi M
AD  - Department of Psychiatry, Teikyo University Chiba Medical Center, 3426-3 Anesaki, 
      Ichihara, 299-0111 Japan.
FAU - Suzuki, Masatoshi
AU  - Suzuki M
AD  - Department of Psychiatry, Teikyo University Chiba Medical Center, 3426-3 Anesaki, 
      Ichihara, 299-0111 Japan.
FAU - Sato, Koichi
AU  - Sato K
AD  - Department of Psychiatry, Teikyo University Chiba Medical Center, 3426-3 Anesaki, 
      Ichihara, 299-0111 Japan.
FAU - Shirayama, Yukihiko
AU  - Shirayama Y
AD  - Department of Psychiatry, Teikyo University Chiba Medical Center, 3426-3 Anesaki, 
      Ichihara, 299-0111 Japan.
LA  - eng
PT  - Journal Article
DEP - 20160120
PL  - England
TA  - Ann Gen Psychiatry
JT  - Annals of general psychiatry
JID - 101236515
PMC - PMC4719701
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - COGNISTAT
OT  - Cognition
OT  - HAM-D
OT  - Late-life depression
OT  - MMSE
EDAT- 2016/01/23 06:00
MHDA- 2016/01/23 06:01
PMCR- 2016/01/20
CRDT- 2016/01/22 06:00
PHST- 2015/09/09 00:00 [received]
PHST- 2016/01/07 00:00 [accepted]
PHST- 2016/01/22 06:00 [entrez]
PHST- 2016/01/23 06:00 [pubmed]
PHST- 2016/01/23 06:01 [medline]
PHST- 2016/01/20 00:00 [pmc-release]
AID - 91 [pii]
AID - 10.1186/s12991-016-0091-5 [doi]
PST - epublish
SO  - Ann Gen Psychiatry. 2016 Jan 20;15:3. doi: 10.1186/s12991-016-0091-5. eCollection 
      2016.