PMID- 26794008
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20240129
IS  - 1532-2688 (Electronic)
IS  - 1059-1311 (Linking)
VI  - 35
DP  - 2016 Feb
TI  - Optical coherence tomography parameters in patients with photosensitive juvenile 
      myoclonic epilepsy.
PG  - 36-40
LID - S1059-1311(15)00295-2 [pii]
LID - 10.1016/j.seizure.2015.12.014 [doi]
AB  - PURPOSE: Juvenile myoclonic epilepsy (JME) is commonly associated with 
      photoparoxysmal response (PPR) with a reported prevalence of 25-42%. In this 
      study, we aim to explore the relationship between the PPR and Optical Coherence 
      Tomography (OCT) parameters in order to determine whether optic nerve fiber layer 
      or other structural differences have a pathophysiological role of 
      photosensitivity in patients with JME. METHODS: We studied 53 consecutive 
      patients with Juvenile myoclonic epilepsy (JME) at our outpatient department. The 
      interictal electroencephalogram (EEG) findings for each patient were analyzed for 
      the presence of photoparoxysmal features. The peripapillary Retina Nerve Fiber 
      Layer (RNFL) thickness, ganglion cell thickness, macular thickness and choroid 
      thickness levels were analyzed using OCT. RESULTS: We classified the patients 
      into two groups as those with PPR (Group 1) and those without PPR (Group 2). 
      There were statistically significant differences in the average RNFL thickness 
      values of the left eye between the two groups (p<0.001). Although the RNFL 
      thickness of the right eye was higher in Group 1, no statistically significant 
      difference was observed between the two groups. The RFNL thickness of the 
      superior quadrants both in the right and the left eyes was significantly higher 
      in Group 1 patients (p<0.001). Macular thickness of the right and left eyes were 
      significantly thinner in Group 1 patients (p<0.001). Choroid thickness of the 
      left eye was significantly higher in Group 1 than in Group 2 patients (p<0.001). 
      Although the choroid thickness of the right eye was higher in Group 1 patients, 
      no statistically significant difference was observed between the two groups. 
      CONCLUSION: This is the first study to our knowledge which has investigated the 
      relation between the OCT parameters and photosensitivity in patients with JME. We 
      concluded that these microstructural features may be related to photosensitivity 
      in patients with JME.
CI  - Copyright (c) 2015 British Epilepsy Association. Published by Elsevier Ltd. All 
      rights reserved.
FAU - Gomceli, Yasemin Bicer
AU  - Gomceli YB
AD  - Uncali mah. 30. Cad. Binbirgece konaklari E blok No:7, Konyaalti, Antalya, 
      Turkey. Electronic address: yasemingomceli@hotmail.com.
FAU - Dogan, Berna
AU  - Dogan B
AD  - Uncali mah. 30. Cad. Binbirgece konaklari E blok No:7, Konyaalti, Antalya, 
      Turkey.
FAU - Genc, Fatma
AU  - Genc F
AD  - Uncali mah. 30. Cad. Binbirgece konaklari E blok No:7, Konyaalti, Antalya, 
      Turkey.
FAU - Uygur, Elif
AU  - Uygur E
AD  - Uncali mah. 30. Cad. Binbirgece konaklari E blok No:7, Konyaalti, Antalya, 
      Turkey.
FAU - Turgut Coban, Deniz
AU  - Turgut Coban D
AD  - Uncali mah. 30. Cad. Binbirgece konaklari E blok No:7, Konyaalti, Antalya, 
      Turkey.
FAU - Erdal, Abidin
AU  - Erdal A
AD  - Uncali mah. 30. Cad. Binbirgece konaklari E blok No:7, Konyaalti, Antalya, 
      Turkey.
FAU - Kazim Erol, Muhammed
AU  - Kazim Erol M
AD  - Uncali mah. 30. Cad. Binbirgece konaklari E blok No:7, Konyaalti, Antalya, 
      Turkey.
LA  - eng
PT  - Journal Article
DEP - 20151230
PL  - England
TA  - Seizure
JT  - Seizure
JID - 9306979
RN  - 0 (Anticonvulsants)
SB  - IM
MH  - Anticonvulsants/therapeutic use
MH  - Electroencephalography
MH  - Epilepsy, Reflex/complications/drug therapy/*pathology
MH  - Female
MH  - Humans
MH  - Male
MH  - Myoclonic Epilepsy, Juvenile/complications/*diagnosis/drug therapy
MH  - Retina/*diagnostic imaging
MH  - *Tomography, Optical Coherence
MH  - Visual Pathways/diagnostic imaging
OTO - NOTNLM
OT  - EEG
OT  - Generalized epilepsy.
OT  - Photoparoxysmal EEG response
OT  - Retinal Nerve Fiber Layer
EDAT- 2016/01/23 06:00
MHDA- 2016/12/15 06:00
CRDT- 2016/01/23 06:00
PHST- 2015/10/23 00:00 [received]
PHST- 2015/12/23 00:00 [revised]
PHST- 2015/12/25 00:00 [accepted]
PHST- 2016/01/23 06:00 [entrez]
PHST- 2016/01/23 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
AID - S1059-1311(15)00295-2 [pii]
AID - 10.1016/j.seizure.2015.12.014 [doi]
PST - ppublish
SO  - Seizure. 2016 Feb;35:36-40. doi: 10.1016/j.seizure.2015.12.014. Epub 2015 Dec 30.