PMID- 26794252 OWN - NLM STAT- MEDLINE DCOM- 20161213 LR - 20220409 IS - 1872-6240 (Electronic) IS - 0006-8993 (Linking) VI - 1635 DP - 2016 Mar 15 TI - Intracranial pressure (ICP) and optic nerve subarachnoid space pressure (ONSP) correlation in the optic nerve chamber: the Beijing Intracranial and Intraocular Pressure (iCOP) study. PG - 201-8 LID - S0006-8993(16)00023-8 [pii] LID - 10.1016/j.brainres.2016.01.011 [doi] AB - PURPOSE: Because a lowered intracranial pressure (ICP) is a possible mechanism of optic neuropathy, we wished to study the CSF dynamics in the optic nerve chamber by recording possible changes in the optic nerve subarachnoid space pressure (ONSP) and the impact on it when acutely lowering ICP. METHODS: In eight normal dogs pressure probes were implanted in the left brain ventricle, lumbar cistern, optic nerve subarachnoid space and in the anterior eye chamber. Following CSF shunting from the brain ventricle we monitored changes of ICP, lumbar cistern pressure (LCP), ONSP and intraocular pressure (IOP). RESULTS: At baseline, the pressures were different with ICP>LCP>ONSP but correlated with each other (P<0.001). The "trans-lamina cribrosa pressure gradient" (TLPG) was highest for IOP-ONSP, lower for IOP-LCP, and lowest for IOP-ICP (P<0.001). During CSF shunting the ICP gradually decreased in a linear fashion together with the ONSP ("ICP-depended zone"). But when the ICP fell below a critical breakpoint, ICP and ONSP became uncoupled and ONSP remained constant despite further ICP decline ("ICP-independent zone"). CONCLUSIONS: Because the parallel decline of ICP and ONSP breaks down when ICP decreases below a critical breakpoint, we interpret this as a sign of CSF communication arrest between the intracranial and optic nerve SAS. This may be caused by obstructions of either CSF inflow through the optic canal or outflow into the intra-orbital cavity. This CSF exchange arrest may be a contributing factor to optic nerve damage and the optic nerve chamber syndrome which may influence the loss of vision or its restoration. CI - Copyright (c) 2016 Elsevier B.V. All rights reserved. FAU - Hou, Ruowu AU - Hou R AD - Department of Neurosurgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China. FAU - Zhang, Zheng AU - Zhang Z AD - Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China. FAU - Yang, Diya AU - Yang D AD - Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China; Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China. FAU - Wang, Huaizhou AU - Wang H AD - Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China; Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China. FAU - Chen, Weiwei AU - Chen W AD - Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China. FAU - Li, Zhen AU - Li Z AD - Department of Ophthalmology, Xuanwu Hospital, Capital Medical University, Beijing, China. FAU - Sang, Jinghong AU - Sang J AD - Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China. FAU - Liu, Sumeng AU - Liu S AD - Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China. FAU - Cao, Yiwen AU - Cao Y AD - Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China. FAU - Xie, Xiaobin AU - Xie X AD - Department of Ophthalmology, Eye Hospital of China Academy of Chinese Medical Sciences, Beijing, China. FAU - Ren, Ruojin AU - Ren R AD - Eye center, New York Eye and Ear Infirmary, NY, USA. FAU - Zhang, Yazhuo AU - Zhang Y AD - Department of Endoscopic and Microinvasive Neurosugery, Beijing Neurosurgery Institute, Beijing Tiantian Hospital, Capital Medical University, Beijing, China. Electronic address: zyz2004520@163.com. FAU - Sabel, Bernhard A AU - Sabel BA AD - Institute of Medical Psychology, Medical Faculty, Otto-v.-Guericke University of Magdeburg, Magdeburg, Germany. FAU - Wang, Ningli AU - Wang N AD - Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China; Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China. Electronic address: wningli@vip.163.com. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20160112 PL - Netherlands TA - Brain Res JT - Brain research JID - 0045503 SB - IM MH - Animals MH - Beijing MH - Dogs MH - Hydrodynamics MH - *Intracranial Pressure MH - Intraocular Pressure/*physiology MH - Optic Nerve/*physiology MH - Subarachnoid Space/*physiology OTO - NOTNLM OT - Cerebrospinal fluid dynamics OT - Glaucoma OT - Optic nerve chamber OT - Optic nerve subarachnoid space pressure (ONSP) OT - Optic neuropathy OT - Trans-optic canal pressure gradient (TCPG) EDAT- 2016/01/23 06:00 MHDA- 2016/12/15 06:00 CRDT- 2016/01/23 06:00 PHST- 2015/12/14 00:00 [received] PHST- 2016/01/06 00:00 [revised] PHST- 2016/01/07 00:00 [accepted] PHST- 2016/01/23 06:00 [entrez] PHST- 2016/01/23 06:00 [pubmed] PHST- 2016/12/15 06:00 [medline] AID - S0006-8993(16)00023-8 [pii] AID - 10.1016/j.brainres.2016.01.011 [doi] PST - ppublish SO - Brain Res. 2016 Mar 15;1635:201-8. doi: 10.1016/j.brainres.2016.01.011. Epub 2016 Jan 12.