PMID- 26794752
OWN - NLM
STAT- MEDLINE
DCOM- 20161028
LR  - 20161230
IS  - 1879-1344 (Electronic)
IS  - 0144-8617 (Linking)
VI  - 138
DP  - 2016 Mar 15
TI  - Preparation of starch nanoparticles in water in oil microemulsion system and 
      their drug delivery properties.
PG  - 192-200
LID - S0144-8617(15)01095-4 [pii]
LID - 10.1016/j.carbpol.2015.11.006 [doi]
AB  - In this research, 1-hexadecyl-3-methylimidazolium bromide 
      C16mimBr/butan-1-ol/cyclohexane/water ionic liquid microemulsion was prepared. 
      The effects of n-alkyl alcohols, alkanes, water content and temperature on the 
      properties of microemulsion were studied by dilution experiment. The microregion 
      of microemulsion was identified by pseudo-ternary phase diagram and conductivity 
      measurement. Then starch nanoparticles were prepared by water in oil (W/O) 
      microemulsion-cross-linking methods with C16mimBr as surfactant. Starch 
      nanoparticles with a mean diameter of 94.3nm and narrow size distribution 
      (SD=3.3) were confirmed by dynamic light scattering (DLS). Scanning electron 
      microscope (SEM) data revealed that starch nanoparticles were spherical granules 
      with the size about 60nm. Moreover the results of Fourier transform infrared 
      spectroscopy (FTIR) and X-ray diffraction (XRD) demonstrated the formation of 
      cross-linking bonds in starch molecules. Finally, the drug loading and releasing 
      properties of starch nanoparticles were investigated with methylene blue (MB) as 
      drug model. This work may provide an efficient pathway to synthesis starch 
      nanoparticles.
CI  - Copyright (c) 2015 Elsevier Ltd. All rights reserved.
FAU - Wang, Xinge
AU  - Wang X
AD  - Carbohydrate Lab, College of Light Industry and Food Science, South China 
      University of Technology, Guangzhou 510640, China.
FAU - Chen, Haiming
AU  - Chen H
AD  - Carbohydrate Lab, College of Light Industry and Food Science, South China 
      University of Technology, Guangzhou 510640, China; College of Food Sciences & 
      Engineering, Hainan University, 58 People Road, Haikou, China.
FAU - Luo, Zhigang
AU  - Luo Z
AD  - Carbohydrate Lab, College of Light Industry and Food Science, South China 
      University of Technology, Guangzhou 510640, China. Electronic address: 
      zhgluo@scut.edu.cn.
FAU - Fu, Xiong
AU  - Fu X
AD  - Carbohydrate Lab, College of Light Industry and Food Science, South China 
      University of Technology, Guangzhou 510640, China. Electronic address: 
      lfxfu@scut.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151106
PL  - England
TA  - Carbohydr Polym
JT  - Carbohydrate polymers
JID - 8307156
RN  - 0 (1-hexadecyl-3-methylimidazolium bromide)
RN  - 0 (Drug Carriers)
RN  - 0 (Emulsions)
RN  - 0 (Imidazoles)
RN  - 0 (Oils)
RN  - 059QF0KO0R (Water)
RN  - 9005-25-8 (Starch)
RN  - T42P99266K (Methylene Blue)
SB  - IM
MH  - Drug Carriers/*chemistry
MH  - Dynamic Light Scattering
MH  - Emulsions/*chemistry
MH  - Imidazoles/chemistry
MH  - Methylene Blue/*chemistry/metabolism
MH  - Microscopy, Electron, Scanning
MH  - Nanoparticles/*chemistry
MH  - Oils/chemistry
MH  - Spectroscopy, Fourier Transform Infrared
MH  - Starch/*chemistry
MH  - Temperature
MH  - Water/chemistry
MH  - X-Ray Diffraction
OTO - NOTNLM
OT  - C(16)mimBr
OT  - Ionic liquid
OT  - Microemulsion
OT  - Nanoparticles
OT  - Starch
EDAT- 2016/01/23 06:00
MHDA- 2016/11/01 06:00
CRDT- 2016/01/23 06:00
PHST- 2015/06/15 00:00 [received]
PHST- 2015/11/02 00:00 [revised]
PHST- 2015/11/04 00:00 [accepted]
PHST- 2016/01/23 06:00 [entrez]
PHST- 2016/01/23 06:00 [pubmed]
PHST- 2016/11/01 06:00 [medline]
AID - S0144-8617(15)01095-4 [pii]
AID - 10.1016/j.carbpol.2015.11.006 [doi]
PST - ppublish
SO  - Carbohydr Polym. 2016 Mar 15;138:192-200. doi: 10.1016/j.carbpol.2015.11.006. 
      Epub 2015 Nov 6.