PMID- 26794956
OWN - NLM
STAT- MEDLINE
DCOM- 20161102
LR  - 20210702
IS  - 1879-1344 (Electronic)
IS  - 0144-8617 (Linking)
VI  - 139
DP  - 2016 Mar 30
TI  - Electrospinning chitosan/poly(ethylene oxide) solutions with essential oils: 
      Correlating solution rheology to nanofiber formation.
PG  - 131-8
LID - S0144-8617(15)01163-7 [pii]
LID - 10.1016/j.carbpol.2015.11.073 [doi]
AB  - Electrospinning hydrophilic nanofiber mats that deliver hydrophobic agents would 
      enable the development of new therapeutic wound dressings. However, the 
      correlation between precursor solution properties and nanofiber morphology for 
      polymer solutions electrospun with or without hydrophobic oils has not yet been 
      demonstrated. Here, cinnamaldehyde (CIN) and hydrocinnamic alcohol (H-CIN) were 
      electrospun in chitosan (CS)/poly(ethylene oxide) (PEO) nanofiber mats as a 
      function of CS molecular weight and degree of acetylation (DA). Viscosity stress 
      sweeps determined how the oils affected solution viscosity and chain entanglement 
      (Ce) concentration. Experimentally, the maximum polymer:oil mass ratio 
      electrospun was 1:3 and 1:6 for CS/PEO:CIN and:H-CIN, respectively; a higher 
      chitosan DA increased the incorporation of H-CIN only. The correlations 
      determined for electrospinning plant-derived oils could potentially be applied to 
      other hydrophobic molecules, thus broadening the delivery of therapeutics from 
      electrospun nanofiber mats.
CI  - Copyright (c) 2015 Elsevier Ltd. All rights reserved.
FAU - Rieger, Katrina A
AU  - Rieger KA
AD  - Department of Chemical Engineering, University of Massachusetts Amherst, Amherst, 
      MA 01003-9303, United States.
FAU - Birch, Nathan P
AU  - Birch NP
AD  - Department of Chemical Engineering, University of Massachusetts Amherst, Amherst, 
      MA 01003-9303, United States.
FAU - Schiffman, Jessica D
AU  - Schiffman JD
AD  - Department of Chemical Engineering, University of Massachusetts Amherst, Amherst, 
      MA 01003-9303, United States. Electronic address: schiffman@ecs.umass.edu.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20151202
PL  - England
TA  - Carbohydr Polym
JT  - Carbohydrate polymers
JID - 8307156
RN  - 0 (Alcohols)
RN  - 0 (Oils, Volatile)
RN  - 0 (Solutions)
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
RN  - 7864XYD3JJ (Acrolein)
RN  - 9012-76-4 (Chitosan)
RN  - SR60A3XG0F (cinnamaldehyde)
SB  - IM
MH  - Acrolein/analogs & derivatives/chemistry
MH  - Alcohols/chemistry
MH  - Chitosan/*chemistry
MH  - Hydrophobic and Hydrophilic Interactions
MH  - Molecular Weight
MH  - Nanofibers/*chemistry
MH  - Oils, Volatile/*chemistry
MH  - Polyethylene Glycols/*chemistry
MH  - Rheology
MH  - Solutions
MH  - Technology, Pharmaceutical
MH  - Viscosity
OTO - NOTNLM
OT  - Chitosan
OT  - Electrospin
OT  - Essential oil
OT  - Nanofiber
OT  - Oil-in-water
OT  - Rheology
EDAT- 2016/01/23 06:00
MHDA- 2016/11/03 06:00
CRDT- 2016/01/23 06:00
PHST- 2015/09/04 00:00 [received]
PHST- 2015/11/05 00:00 [revised]
PHST- 2015/11/28 00:00 [accepted]
PHST- 2016/01/23 06:00 [entrez]
PHST- 2016/01/23 06:00 [pubmed]
PHST- 2016/11/03 06:00 [medline]
AID - S0144-8617(15)01163-7 [pii]
AID - 10.1016/j.carbpol.2015.11.073 [doi]
PST - ppublish
SO  - Carbohydr Polym. 2016 Mar 30;139:131-8. doi: 10.1016/j.carbpol.2015.11.073. Epub 
      2015 Dec 2.