PMID- 26795125
OWN - NLM
STAT- MEDLINE
DCOM- 20170731
LR  - 20181202
IS  - 1532-2750 (Electronic)
IS  - 1098-612X (Linking)
VI  - 19
IP  - 4
DP  - 2017 Apr
TI  - Relationship between vitamin D status and leukocytes in hospitalised cats.
PG  - 364-369
LID - 10.1177/1098612X15625454 [doi]
AB  - Objectives Vitamin D deficiency, as assessed by serum 25-hydroxyvitamin D 
      (25[OH]D) concentrations, has been linked to markers of systemic inflammation in 
      human and canine medicine. However, the relationship between vitamin D status and 
      inflammation has not been previously investigated in cats. The aim of this study 
      was to examine the relationship between serum 25(OH)D concentrations and 
      leukocyte counts in hospitalised sick cats. Methods Serum 25(OH)D concentrations 
      and haematology profiles were measured in 170 consecutive hospitalised sick cats. 
      A binary logistical regression model examined the relationship between serum 
      25(OH)D concentration, age, sex, breed and neutrophil, monocyte, eosinophil and 
      lymphocyte counts. Results Cats with neutrophilia had lower serum 25(OH)D 
      concentrations than cats with neutrophil concentrations below the upper limit of 
      the reference interval (RI). There were no differences in serum 25(OH)D 
      concentrations in cats with monocyte, lymphocyte or eosinophil counts above their 
      respective RI compared with cats with counts below the upper limit of the RI. 
      Conclusions and relevance Hospitalised cats with a neutrophil count above the RI 
      had lower vitamin D status. There is a need to establish whether lower vitamin D 
      status is a cause or consequence of increased neutrophil counts.
FAU - Titmarsh, Helen F
AU  - Titmarsh HF
AD  - 1 Royal (Dick) School of Veterinary Studies and The Roslin Institute, The 
      University of Edinburgh, Roslin, UK.
FAU - Cartwright, Jennifer A
AU  - Cartwright JA
AD  - 1 Royal (Dick) School of Veterinary Studies and The Roslin Institute, The 
      University of Edinburgh, Roslin, UK.
FAU - Kilpatrick, Scott
AU  - Kilpatrick S
AD  - 1 Royal (Dick) School of Veterinary Studies and The Roslin Institute, The 
      University of Edinburgh, Roslin, UK.
FAU - Gaylor, Donna
AU  - Gaylor D
AD  - 1 Royal (Dick) School of Veterinary Studies and The Roslin Institute, The 
      University of Edinburgh, Roslin, UK.
FAU - Milne, Elspeth M
AU  - Milne EM
AD  - 1 Royal (Dick) School of Veterinary Studies and The Roslin Institute, The 
      University of Edinburgh, Roslin, UK.
FAU - Berry, Jacqueline L
AU  - Berry JL
AD  - 2 Specialist Assay Laboratory (Vitamin D), Clinical Biochemistry, Manchester 
      Royal Infirmary, Manchester, UK.
FAU - Bommer, Nicholas X
AU  - Bommer NX
AD  - 1 Royal (Dick) School of Veterinary Studies and The Roslin Institute, The 
      University of Edinburgh, Roslin, UK.
FAU - Gunn-Moore, Danielle
AU  - Gunn-Moore D
AD  - 1 Royal (Dick) School of Veterinary Studies and The Roslin Institute, The 
      University of Edinburgh, Roslin, UK.
FAU - Reed, Nicola
AU  - Reed N
AD  - 1 Royal (Dick) School of Veterinary Studies and The Roslin Institute, The 
      University of Edinburgh, Roslin, UK.
AD  - Current address: Wear Referrals, Stockton-on-Tees, UK.
FAU - Handel, Ian
AU  - Handel I
AD  - 1 Royal (Dick) School of Veterinary Studies and The Roslin Institute, The 
      University of Edinburgh, Roslin, UK.
FAU - Mellanby, Richard J
AU  - Mellanby RJ
AD  - 1 Royal (Dick) School of Veterinary Studies and The Roslin Institute, The 
      University of Edinburgh, Roslin, UK.
LA  - eng
PT  - Journal Article
DEP - 20160709
PL  - England
TA  - J Feline Med Surg
JT  - Journal of feline medicine and surgery
JID - 100897329
RN  - 0 (Biomarkers)
RN  - 1406-16-2 (Vitamin D)
RN  - A288AR3C9H (25-hydroxyvitamin D)
SB  - IM
MH  - Animals
MH  - Biomarkers/*blood
MH  - Case-Control Studies
MH  - Cat Diseases/blood/*diagnosis
MH  - Cats
MH  - Female
MH  - Hospitalization
MH  - Leukocyte Count/veterinary
MH  - Male
MH  - Vitamin D/*analogs & derivatives/blood
MH  - Vitamin D Deficiency/blood/diagnosis/*veterinary
EDAT- 2016/01/23 06:00
MHDA- 2017/08/02 06:00
CRDT- 2016/01/23 06:00
PHST- 2016/01/23 06:00 [pubmed]
PHST- 2017/08/02 06:00 [medline]
PHST- 2016/01/23 06:00 [entrez]
AID - 1098612X15625454 [pii]
AID - 10.1177/1098612X15625454 [doi]
PST - ppublish
SO  - J Feline Med Surg. 2017 Apr;19(4):364-369. doi: 10.1177/1098612X15625454. Epub 
      2016 Jul 9.