PMID- 26795846
OWN - NLM
STAT- MEDLINE
DCOM- 20161006
LR  - 20181202
IS  - 1573-2517 (Electronic)
IS  - 0165-0327 (Linking)
VI  - 194
DP  - 2016 Apr
TI  - BDNF val66met polymorphism and depressive disorders in patients with acute 
      coronary syndrome.
PG  - 1-8
LID - S0165-0327(15)31285-4 [pii]
LID - 10.1016/j.jad.2016.01.033 [doi]
AB  - INTRODUCTION: Brain-derived neurotrophic factor (BDNF) may be the key to 
      understanding the development of depression in patients with acute coronary 
      syndrome (ACS), as it is associated with both conditions. Because the expression 
      of BDNF is influenced by genetic polymorphisms, in this study we investigated the 
      association between the BDNF polymorphism val66met and both the risk of 
      depression in ACS and the treatment response. METHODS: Among the 969 patients 
      with recent ACS at baseline, 711 were re-evaluated after 1 year of follow-up. 
      Depressive disorder status was assessed according to the DSM-IV criteria both at 
      baseline and at follow-up. Baseline prevalence, follow-up incidence, and the 
      persistence of depression were also determined. Of the 378 patients diagnosed 
      with depression at baseline, 255 were randomized to a 24-week double-blind 
      placebo-controlled trial of escitalopram; the remaining 123 received the usual 
      care. Associations between the BDNF val66met polymorphism and both depression 
      status and treatment response were investigated using logistic regression models. 
      RESULTS: The prevalence and persistence, but not the incidence of depressive 
      disorders were significantly associated with BDNF met alleles. Patients in the 
      escitalopram group who carried the met allele had a significantly higher rate of 
      remission than those who did not. Depressive disorders tended to persist at 1 
      year in patients managed with placebo or medical treatment only, and particularly 
      those patients positive for BDNF met alleles, although the difference was not 
      statistically significant. LIMITATIONS: The generalizability should be considered 
      since this study conducted in a single center. CONCLUSIONS: ACS patients positive 
      for BDNF met alleles are vulnerable to depressive disorders at baseline and to 
      its persistence. Antidepressant treatment may be effective in this subgroup of 
      patients and may prevent the persistence of depression.
CI  - Copyright (c) 2016 Elsevier B.V. All rights reserved.
FAU - Kang, Hee-Ju
AU  - Kang HJ
AD  - Department of Psychiatry, Chonnam National University Medical School, Gwangju, 
      Republic of Korea.
FAU - Bae, Kyung-Yeol
AU  - Bae KY
AD  - Department of Psychiatry, Chonnam National University Medical School, Gwangju, 
      Republic of Korea.
FAU - Kim, Sung-Wan
AU  - Kim SW
AD  - Department of Psychiatry, Chonnam National University Medical School, Gwangju, 
      Republic of Korea.
FAU - Shin, Il-Seon
AU  - Shin IS
AD  - Department of Psychiatry, Chonnam National University Medical School, Gwangju, 
      Republic of Korea.
FAU - Hong, Young Joon
AU  - Hong YJ
AD  - Department of Cardiology, Chonnam National University Medical School, Gwangju, 
      Republic of Korea.
FAU - Ahn, Youngkeun
AU  - Ahn Y
AD  - Department of Cardiology, Chonnam National University Medical School, Gwangju, 
      Republic of Korea.
FAU - Jeong, Myung Ho
AU  - Jeong MH
AD  - Department of Cardiology, Chonnam National University Medical School, Gwangju, 
      Republic of Korea.
FAU - Yoon, Jin-Sang
AU  - Yoon JS
AD  - Department of Psychiatry, Chonnam National University Medical School, Gwangju, 
      Republic of Korea.
FAU - Kim, Jae-Min
AU  - Kim JM
AD  - Department of Psychiatry, Chonnam National University Medical School, Gwangju, 
      Republic of Korea. Electronic address: jmkim@chonnam.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20160113
PL  - Netherlands
TA  - J Affect Disord
JT  - Journal of affective disorders
JID - 7906073
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0DHU5B8D6V (Citalopram)
SB  - IM
MH  - Acute Coronary Syndrome/*epidemiology
MH  - Aged
MH  - Alleles
MH  - Antidepressive Agents/therapeutic use
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Citalopram/therapeutic use
MH  - Depressive Disorder/drug therapy/epidemiology/*genetics
MH  - Diagnostic and Statistical Manual of Mental Disorders
MH  - Double-Blind Method
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - Incidence
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Genetic
MH  - Prevalence
MH  - Prospective Studies
MH  - Republic of Korea/epidemiology
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Acute coronary syndrome
OT  - BDNF
OT  - Depression
OT  - Escitalopram
OT  - Polymorphism
EDAT- 2016/01/23 06:00
MHDA- 2016/10/08 06:00
CRDT- 2016/01/23 06:00
PHST- 2015/11/18 00:00 [received]
PHST- 2016/01/06 00:00 [revised]
PHST- 2016/01/12 00:00 [accepted]
PHST- 2016/01/23 06:00 [entrez]
PHST- 2016/01/23 06:00 [pubmed]
PHST- 2016/10/08 06:00 [medline]
AID - S0165-0327(15)31285-4 [pii]
AID - 10.1016/j.jad.2016.01.033 [doi]
PST - ppublish
SO  - J Affect Disord. 2016 Apr;194:1-8. doi: 10.1016/j.jad.2016.01.033. Epub 2016 Jan 
      13.