PMID- 26796595
OWN - NLM
STAT- MEDLINE
DCOM- 20161010
LR  - 20181202
IS  - 1879-0046 (Electronic)
IS  - 0376-8716 (Linking)
VI  - 160
DP  - 2016 Mar 1
TI  - Prevention of drug priming- and cue-induced reinstatement of MDMA-seeking 
      behaviors by the CB1 cannabinoid receptor antagonist AM251.
PG  - 76-81
LID - S0376-8716(15)01831-1 [pii]
LID - 10.1016/j.drugalcdep.2015.12.016 [doi]
AB  - BACKGROUND: 3,4-Methylenedioxymethamphetamine (MDMA), a methamphetamine (METH) 
      derivative, exhibits METH-like actions at monoamine transporters and positive 
      reinforcing effects in rodents and primates. The purposes of the present study 
      were to determine whether cross-reinstatement would be observed between MDMA and 
      METH and if the cannabinoid receptor, a receptor known to play critical roles in 
      the brain reward system, could modulate MDMA craving. METHODS: Rats were trained 
      to press a lever for intravenous MDMA (0.3mg/infusion) or METH (0.02mg/infusion) 
      infusions under a fixed ratio 1 schedule paired with drug-associated cues (light 
      and tone). Following drug self-administration acquisition training, rats 
      underwent extinction training (an infusion of saline). Reinstatement tests were 
      performed once the extinction criteria were achieved. RESULTS: In MDMA-trained 
      rats, the MDMA-priming injection (3.2mg/kg, i.p.) or re-exposure to 
      MDMA-associated cues reinstated MDMA-seeking behavior. Additionally, a priming 
      injection of METH (1.0mg/kg, i.p.) also reinstated MDMA-seeking behavior. In 
      contrast, none of the MDMA doses reinstated METH-seeking behavior in the 
      METH-trained rats. The CB1 cannabinoid receptor antagonist AM251 markedly 
      attenuated the MDMA-seeking behaviors induced by MDMA-priming injection or 
      re-exposure to MDMA-associated cues in a dose-dependent manner. CONCLUSIONS: 
      These findings show that MDMA has obvious addictive potential for reinstating 
      drug-seeking behavior and that METH can be an effective stimulus for reinstating 
      MDMA-seeking behaviors. Furthermore, based on the attenuating effect of AM251 in 
      the reinstatement of MDMA-seeking behaviors, drugs that suppress CB1 receptors 
      may be used in treatment of MDMA dependence.
CI  - Copyright (c) 2016. Published by Elsevier Ireland Ltd.
FAU - Nawata, Yoko
AU  - Nawata Y
AD  - Department of Pharmacology, Faculty of Pharmaceutical Science, Nagasaki 
      International University, 2825-7 Huis Ten Bosch Sasebo, Nagasaki 859-3298, Japan.
FAU - Kitaichi, Kiyoyuki
AU  - Kitaichi K
AD  - Laboratory of Drug Metabolism and Pharmacokinetics, Gifu Pharmaceutical 
      University, 1-25-4 Daigaku-nishi, Gifu 501-1196, Japan.
FAU - Yamamoto, Tsuneyuki
AU  - Yamamoto T
AD  - Department of Pharmacology, Faculty of Pharmaceutical Science, Nagasaki 
      International University, 2825-7 Huis Ten Bosch Sasebo, Nagasaki 859-3298, Japan. 
      Electronic address: tyamamot@niu.co.jp.
LA  - eng
PT  - Journal Article
DEP - 20151230
PL  - Ireland
TA  - Drug Alcohol Depend
JT  - Drug and alcohol dependence
JID - 7513587
RN  - 0 (Cannabinoid Receptor Antagonists)
RN  - 0 (Piperidines)
RN  - 0 (Pyrazoles)
RN  - 3I4FA44MAI (AM 251)
RN  - 44RAL3456C (Methamphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Amphetamine-Related Disorders/drug therapy/psychology
MH  - Animals
MH  - Cannabinoid Receptor Antagonists/*pharmacology/therapeutic use
MH  - *Cues
MH  - Dose-Response Relationship, Drug
MH  - Drug-Seeking Behavior/*drug effects
MH  - Extinction, Psychological/drug effects
MH  - Male
MH  - Methamphetamine/analogs & derivatives/*pharmacology
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Piperidines/*pharmacology
MH  - Pyrazoles/*pharmacology
MH  - Rats
MH  - Self Administration
OTO - NOTNLM
OT  - CB(1) cannabinoid receptor
OT  - Drug-seeking behavior
OT  - MDMA
OT  - Methamphetamine
OT  - Self-administration
EDAT- 2016/01/23 06:00
MHDA- 2016/10/11 06:00
CRDT- 2016/01/23 06:00
PHST- 2015/05/07 00:00 [received]
PHST- 2015/10/10 00:00 [revised]
PHST- 2015/12/14 00:00 [accepted]
PHST- 2016/01/23 06:00 [entrez]
PHST- 2016/01/23 06:00 [pubmed]
PHST- 2016/10/11 06:00 [medline]
AID - S0376-8716(15)01831-1 [pii]
AID - 10.1016/j.drugalcdep.2015.12.016 [doi]
PST - ppublish
SO  - Drug Alcohol Depend. 2016 Mar 1;160:76-81. doi: 10.1016/j.drugalcdep.2015.12.016. 
      Epub 2015 Dec 30.