PMID- 26796715
OWN - NLM
STAT- MEDLINE
DCOM- 20161102
LR  - 20170917
IS  - 1873-3514 (Electronic)
IS  - 0028-3932 (Linking)
VI  - 82
DP  - 2016 Feb
TI  - Modulation of the default-mode network and the attentional network by 
      self-referential processes in patients with disorder of consciousness.
PG  - 149-160
LID - S0028-3932(16)30021-5 [pii]
LID - 10.1016/j.neuropsychologia.2016.01.022 [doi]
AB  - Disorders of consciousness (DOC) are related to an altered capacity of the brain 
      to successfully integrate and segregate information. Alterations in brain 
      functional networks structure have been found in fMRI studies, which could 
      account for the incapability of the brain to efficiently manage internally and 
      externally generated information. Here we assess the modulation of neural 
      activity in areas of the networks related to active introspective or 
      extrospective processing in 9 patients with DOC and 17 controls using fMRI. In 
      addition, we assess the functional connectivity between those areas in resting 
      state. Patients were experimentally studied in an early phase after the event of 
      brain injury (3+/-1 months after the event) and subsequently in a second session 
      4+/-1 months after the first session. The results showed that the concerted 
      modulation of the default mode network (DMN) and attentional network (AN) in 
      response to the active involvement in the task improved with the level of 
      consciousness, reflecting an integral recovery of the brain in its ability to be 
      engaged in cognitive processes. In addition, functional connectivity decreased 
      between the DMN and AN with recovery. Our results help to further understand the 
      neural underpins of the disorders of consciousness.
CI  - Copyright (c) 2016 Elsevier Ltd. All rights reserved.
FAU - Maki-Marttunen, Veronica
AU  - Maki-Marttunen V
AD  - Institute for Neurological Research, F.L.E.N.I., Montaneses 2325, 1428 Buenos 
      Aires, Argentina; CONICET, Buenos Aires, Argentina. Electronic address: 
      makimarttunen.veronica@gmail.com.
FAU - Castro, Mariana
AU  - Castro M
AD  - Institute for Neurological Research, F.L.E.N.I., Montaneses 2325, 1428 Buenos 
      Aires, Argentina; CONICET, Buenos Aires, Argentina.
FAU - Olmos, Lisandro
AU  - Olmos L
AD  - Institute for Neurological Research, F.L.E.N.I., Montaneses 2325, 1428 Buenos 
      Aires, Argentina.
FAU - Leiguarda, Ramon
AU  - Leiguarda R
AD  - Institute for Neurological Research, F.L.E.N.I., Montaneses 2325, 1428 Buenos 
      Aires, Argentina; CONICET, Buenos Aires, Argentina; Departamento de Fisica, 
      Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina.
FAU - Villarreal, Mirta
AU  - Villarreal M
AD  - Institute for Neurological Research, F.L.E.N.I., Montaneses 2325, 1428 Buenos 
      Aires, Argentina; CONICET, Buenos Aires, Argentina; Departamento de Fisica, 
      Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina.
LA  - eng
PT  - Journal Article
DEP - 20160118
PL  - England
TA  - Neuropsychologia
JT  - Neuropsychologia
JID - 0020713
SB  - IM
MH  - Adult
MH  - Attention/*physiology
MH  - Brain Injuries/complications/*physiopathology
MH  - Brain Mapping
MH  - Consciousness Disorders/etiology/*physiopathology
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Neural Pathways/physiopathology
MH  - *Self Concept
MH  - Young Adult
OTO - NOTNLM
OT  - Attentional network
OT  - Consciousness disorders
OT  - Default mode network
OT  - Functional connectivity
OT  - Functional magnetic resonance imaging
OT  - Self-reflection
EDAT- 2016/01/23 06:00
MHDA- 2016/11/03 06:00
CRDT- 2016/01/23 06:00
PHST- 2015/04/14 00:00 [received]
PHST- 2015/11/17 00:00 [revised]
PHST- 2016/01/17 00:00 [accepted]
PHST- 2016/01/23 06:00 [entrez]
PHST- 2016/01/23 06:00 [pubmed]
PHST- 2016/11/03 06:00 [medline]
AID - S0028-3932(16)30021-5 [pii]
AID - 10.1016/j.neuropsychologia.2016.01.022 [doi]
PST - ppublish
SO  - Neuropsychologia. 2016 Feb;82:149-160. doi: 
      10.1016/j.neuropsychologia.2016.01.022. Epub 2016 Jan 18.