PMID- 26797947
OWN - NLM
STAT- MEDLINE
DCOM- 20170404
LR  - 20210109
IS  - 1614-7499 (Electronic)
IS  - 0944-1344 (Linking)
VI  - 23
IP  - 9
DP  - 2016 May
TI  - Assessment of exposure to mixture pollutants in Mexican indigenous children.
PG  - 8577-88
LID - 10.1007/s11356-016-6101-y [doi]
AB  - The aim of the present work was to complete an exposure assessment in three 
      Mexican indigenous communities using the community-based health risk assessment, 
      which is the first step in the CHILD framework. We used 1-hydroxypyrene (1-OHP) 
      as an exposure biomarker to polycyclic aromatic hydrocarbons (PAHs) and trans, 
      trans-muconic acid (t,t-MA) as an exposure biomarker to benzene, persistent 
      organic pollutants (POPs), lead, manganese, arsenic, and fluoride. Anthropometric 
      measurements were also taken. In these communities, high percentages of children 
      with chronic malnutrition were found (28 to 49 %) based on their weight and age. 
      All communities showed a high percentage of children with detectable levels of 
      four or more compounds (70 to 82 %). Additionally, our results showed that in 
      indigenous communities, children are exposed to elevated levels of certain 
      environmental pollutants, including manganese with 17.6, 16.8, and 7.3 mug/L from 
      SMP, TOC, and CUA, respectively. Lead and HCB levels were similar in the 
      indigenous communities (2.5, 3.1, and 4.2 mug/dL and 2.5, 3.1, and 3.7 ng/mL, 
      respectively). 1-OHP and t,t-MA levels were higher in TOC (0.8 mumol/mol of 
      creatinine, 476 mug/g of creatinine, respectively) when compared with SMP 
      (0.1 mumol/mol of creatinine, 215.5 mug/g of creatinine, respectively) and CUA 
      (0.1 mumol/mol of creatinine, 185.2 mug/g of creatinine, respectively). DDE levels 
      were 30.7, 26.9, and 9.6 ng/mL in CUA, SMP, and TOC, respectively. The strength 
      of this study is that it assesses exposure to pollutants with indications for the 
      resultant risk before an intervention is made by the CHILD program to manage this 
      risk in the indigenous communities. Considering the large number of people, 
      especially children, exposed to multiple pollutants, it is important to design 
      effective intervention programs that reduce exposure and the resultant risk in 
      the numerous indigenous communities in Mexico.
FAU - Flores-Ramirez, R
AU  - Flores-Ramirez R
AD  - Catedratico CONACYT-Coordinacion para la Innovacion y Aplicacion de la Ciencia y 
      la Tecnologia (CIACYT), Universidad Autonoma de San Luis Potosi, Avenida Sierra 
      Leona No. 550, Colonia Lomas Segunda Seccion, CP 78210, San Luis Potosi, S.L.P., 
      Mexico.
FAU - Perez-Vazquez, F J
AU  - Perez-Vazquez FJ
AD  - Centro de Investigacion Aplicada en Ambiente y Salud, CIACYT, Facultad de 
      Medicina, Universidad Autonoma de San Luis Potosi, Av. Venustiano Carranza 2405, 
      CP 78210, San Luis Potosi, S.L.P., Mexico.
FAU - Cilia-Lopez, V G
AU  - Cilia-Lopez VG
AD  - Centro de Investigacion Aplicada en Ambiente y Salud, CIACYT, Facultad de 
      Medicina, Universidad Autonoma de San Luis Potosi, Av. Venustiano Carranza 2405, 
      CP 78210, San Luis Potosi, S.L.P., Mexico.
FAU - Zuki-Orozco, B A
AU  - Zuki-Orozco BA
AD  - Centro de Investigacion Aplicada en Ambiente y Salud, CIACYT, Facultad de 
      Medicina, Universidad Autonoma de San Luis Potosi, Av. Venustiano Carranza 2405, 
      CP 78210, San Luis Potosi, S.L.P., Mexico.
FAU - Carrizales, L
AU  - Carrizales L
AD  - Centro de Investigacion Aplicada en Ambiente y Salud, CIACYT, Facultad de 
      Medicina, Universidad Autonoma de San Luis Potosi, Av. Venustiano Carranza 2405, 
      CP 78210, San Luis Potosi, S.L.P., Mexico.
FAU - Batres-Esquivel, L E
AU  - Batres-Esquivel LE
AD  - Centro de Investigacion Aplicada en Ambiente y Salud, CIACYT, Facultad de 
      Medicina, Universidad Autonoma de San Luis Potosi, Av. Venustiano Carranza 2405, 
      CP 78210, San Luis Potosi, S.L.P., Mexico.
FAU - Palacios-Ramirez, A
AU  - Palacios-Ramirez A
AD  - Centro de Investigacion Aplicada en Ambiente y Salud, CIACYT, Facultad de 
      Medicina, Universidad Autonoma de San Luis Potosi, Av. Venustiano Carranza 2405, 
      CP 78210, San Luis Potosi, S.L.P., Mexico.
FAU - Diaz-Barriga, F
AU  - Diaz-Barriga F
AD  - Centro de Investigacion Aplicada en Ambiente y Salud, CIACYT, Facultad de 
      Medicina, Universidad Autonoma de San Luis Potosi, Av. Venustiano Carranza 2405, 
      CP 78210, San Luis Potosi, S.L.P., Mexico. fdia@uaslp.mx.
LA  - eng
PT  - Journal Article
DEP - 20160122
PL  - Germany
TA  - Environ Sci Pollut Res Int
JT  - Environmental science and pollution research international
JID - 9441769
RN  - 0 (Biomarkers)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Polycyclic Aromatic Hydrocarbons)
RN  - 0 (Pyrenes)
RN  - 3KD92ZL2KH (muconic acid)
RN  - AYI8EX34EU (Creatinine)
RN  - J64922108F (Benzene)
RN  - N2H6O5V707 (1-hydroxypyrene)
RN  - N712M78A8G (Arsenic)
RN  - X045WJ989B (Sorbic Acid)
SB  - IM
MH  - Arsenic/metabolism
MH  - Benzene/metabolism
MH  - Biomarkers/metabolism
MH  - Child
MH  - Child, Preschool
MH  - Creatinine
MH  - Environmental Exposure/analysis/*statistics & numerical data
MH  - Environmental Pollutants/analysis/*metabolism
MH  - Female
MH  - Humans
MH  - Male
MH  - Mexico
MH  - Polycyclic Aromatic Hydrocarbons/metabolism
MH  - Pyrenes/*metabolism
MH  - Risk Assessment
MH  - Sorbic Acid/analogs & derivatives/metabolism
OTO - NOTNLM
OT  - Children
OT  - Exposure
OT  - Indigenous
OT  - Pollutants
EDAT- 2016/01/23 06:00
MHDA- 2017/04/05 06:00
CRDT- 2016/01/23 06:00
PHST- 2015/05/12 00:00 [received]
PHST- 2016/01/11 00:00 [accepted]
PHST- 2016/01/23 06:00 [entrez]
PHST- 2016/01/23 06:00 [pubmed]
PHST- 2017/04/05 06:00 [medline]
AID - 10.1007/s11356-016-6101-y [pii]
AID - 10.1007/s11356-016-6101-y [doi]
PST - ppublish
SO  - Environ Sci Pollut Res Int. 2016 May;23(9):8577-88. doi: 
      10.1007/s11356-016-6101-y. Epub 2016 Jan 22.