PMID- 26799159
OWN - NLM
STAT- MEDLINE
DCOM- 20170613
LR  - 20220331
IS  - 1365-2133 (Electronic)
IS  - 0007-0963 (Linking)
VI  - 174
IP  - 6
DP  - 2016 Jun
TI  - Skin expression of mammalian target of rapamycin and forkhead box transcription 
      factor O1, and serum insulin-like growth factor-1 in patients with acne vulgaris 
      and their relationship with diet.
PG  - 1299-307
LID - 10.1111/bjd.14409 [doi]
AB  - BACKGROUND: Acne vulgaris is a multifactorial disorder of the pilosebaceous 
      units. Several studies have reported that insulin-like growth factor (IGF)-1, 
      forkhead box transcription factor (Fox)O1 and mammalian target of rapamycin 
      (mTOR) interactions may be the key to understanding the links between genetic and 
      environmental factors in acne vulgaris. OBJECTIVES: To evaluate the 
      immunohistochemical detection of mTOR and FoxO1 in the skin, and the serum level 
      of IGF-1 in patients with acne vulgaris. METHODS: This study was carried out on 
      60 participants, including 40 patients with acne and 20 controls. A diet 
      questionnaire was administered to the patients and controls. Serum levels of 
      IGF-1 were measured using enzyme-linked immunosorbent assay, and skin biopsies 
      were taken from lesions on the backs of the patients and controls. FoxO1 and mTOR 
      expression was detected using immunohistochemistry. RESULTS: A significantly 
      higher serum IGF-1 level was found in the patients with acne than in the 
      controls. The cytoplasmic expression of FoxO1 was found to be significantly 
      greater in the acne group, whereas in the control subjects this expression was 
      likely to be nuclear. Both the cytoplasmic expression and the nuclear expression 
      of mTOR were significantly more intense in the patients with acne than in the 
      controls. Excess consumption of a high-glycaemic-load diet was significantly 
      associated with higher serum levels of IGF-1 and cytoplasmic expression of FoxO1 
      and mTOR. CONCLUSIONS: These results suggest that FoxO1, mTOR, serum IGF-1 and a 
      high-glycaemic-load diet may play a role in acne pathogenesis.
CI  - (c) 2016 British Association of Dermatologists.
FAU - Agamia, N F
AU  - Agamia NF
AD  - Department of Dermatology, Venereology and Andrology, Faculty of Medicine, 
      Alexandria University, Alexandria, Egypt.
FAU - Abdallah, D M
AU  - Abdallah DM
AD  - Department of Pathology, Faculty of Medicine, Alexandria University, Alexandria, 
      Egypt.
FAU - Sorour, O
AU  - Sorour O
AD  - Department of Dermatology, Venereology and Andrology, Faculty of Medicine, 
      Alexandria University, Alexandria, Egypt.
FAU - Mourad, B
AU  - Mourad B
AD  - Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Tanta 
      University, Tanta, Egypt.
FAU - Younan, D N
AU  - Younan DN
AD  - Department of Clinical Pathology, Faculty of Medicine, Alexandria University, 
      Alexandria, Egypt.
LA  - eng
PT  - Journal Article
DEP - 20160420
PL  - England
TA  - Br J Dermatol
JT  - The British journal of dermatology
JID - 0004041
RN  - 0 (Forkhead Transcription Factors)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Acne Vulgaris/*etiology/metabolism
MH  - Adult
MH  - Case-Control Studies
MH  - Diet/*adverse effects
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Forkhead Transcription Factors/*metabolism
MH  - Humans
MH  - Immunohistochemistry
MH  - Insulin-Like Growth Factor I/*metabolism
MH  - Life Style
MH  - Male
MH  - Skin/metabolism
MH  - TOR Serine-Threonine Kinases/*metabolism
MH  - Young Adult
EDAT- 2016/01/23 06:00
MHDA- 2017/06/14 06:00
CRDT- 2016/01/23 06:00
PHST- 2016/01/15 00:00 [accepted]
PHST- 2016/01/23 06:00 [entrez]
PHST- 2016/01/23 06:00 [pubmed]
PHST- 2017/06/14 06:00 [medline]
AID - 10.1111/bjd.14409 [doi]
PST - ppublish
SO  - Br J Dermatol. 2016 Jun;174(6):1299-307. doi: 10.1111/bjd.14409. Epub 2016 Apr 
      20.