PMID- 26799684
OWN - NLM
STAT- MEDLINE
DCOM- 20171116
LR  - 20220310
IS  - 1398-9995 (Electronic)
IS  - 0105-4538 (Linking)
VI  - 71
IP  - 5
DP  - 2016 May
TI  - Eosinophilic esophagitis is characterized by a non-IgE-mediated food 
      hypersensitivity.
PG  - 611-20
LID - 10.1111/all.12846 [doi]
AB  - Eosinophilic esophagitis (EoE) is a chronic disease characterized clinically by 
      symptoms of esophageal dysfunction and histologically by eosinophil-predominant 
      inflammation. EoE is frequently associated with concomitant atopic diseases and 
      immunoglobulin E (IgE) sensitization to food allergens in children as well as to 
      aeroallergens and cross-reactive plant allergen components in adults. Patients 
      with EoE respond well to elemental and empirical food elimination diets. Recent 
      research has, however, indicated that the pathogenesis of EoE is distinct from 
      IgE-mediated food allergy. In this review, we discuss the individual roles of 
      epithelial barrier defects, dysregulated innate and adaptive immune responses, 
      and of microbiota in the pathogenesis of EoE. Although food has been recognized 
      as a trigger factor of EoE, the mechanism by which it initiates or facilitates 
      eosinophilic inflammation appears to be largely independent of IgE and needs to 
      be further investigated. Understanding the pathogenic role of food in EoE is a 
      prerequisite for the development of specific diagnostic tools and targeted 
      therapeutic procedures.
CI  - (c) 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Simon, D
AU  - Simon D
AD  - Department of Dermatology, Inselspital, Bern University Hospital, University of 
      Bern, Bern, Switzerland.
FAU - Cianferoni, A
AU  - Cianferoni A
AD  - Division of Allergy and Immunology, Children's Hospital Philadelphia, University 
      of Pennsylvania, Philadelphia, PA, USA.
AD  - Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
FAU - Spergel, J M
AU  - Spergel JM
AD  - Division of Allergy and Immunology, Children's Hospital Philadelphia, University 
      of Pennsylvania, Philadelphia, PA, USA.
AD  - Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
FAU - Aceves, S
AU  - Aceves S
AD  - Division of Allergy and Immunology, Department of Pediatrics and Medicine, Center 
      for Infection, Inflammation, and Immunology, La Jolla, CA, USA.
FAU - Holbreich, M
AU  - Holbreich M
AD  - Allergy and Asthma Consultants, Indianapolis, IN, USA.
FAU - Venter, C
AU  - Venter C
AD  - Division of Allergy and Immunology, Cincinnati Children's Hospital Medical 
      Center, Cincinnati, OH, USA.
AD  - School of Health Sciences and Social Work, University of Portsmouth, Portsmouth, 
      UK.
FAU - Rothenberg, M E
AU  - Rothenberg ME
AD  - Division of Allergy and Immunology, Cincinnati Children's Hospital Medical 
      Center, Cincinnati, OH, USA.
FAU - Terreehorst, I
AU  - Terreehorst I
AD  - Department of ENT and Pediatrics, AMC, Amsterdam, The Netherlands.
FAU - Muraro, A
AU  - Muraro A
AD  - Food Allergy Referral Centre Veneto Region, Padua General University Hospital, 
      Padua, Italy.
FAU - Lucendo, A J
AU  - Lucendo AJ
AD  - Department of Gastroenterology, Hospital General de Tomelloso, Tomelloso, Spain.
FAU - Schoepfer, A
AU  - Schoepfer A
AD  - Division of Gastroenterology and Hepatology, Centre Hospitalier Universitaire 
      Vaudois/CHUV, Lausanne, Switzerland.
FAU - Straumann, A
AU  - Straumann A
AD  - Swiss EoE Research Network, Olten, Switzerland.
FAU - Simon, H-U
AU  - Simon HU
AD  - Institute of Pharmacology, University of Bern, Bern, Switzerland.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20160225
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
RN  - 0 (Allergens)
RN  - 0 (Anti-Asthmatic Agents)
RN  - 2P471X1Z11 (Omalizumab)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Allergens/immunology
MH  - Anti-Asthmatic Agents/therapeutic use
MH  - Eosinophilic Esophagitis/*diagnosis/drug therapy/*etiology/metabolism
MH  - Epithelium/immunology/metabolism/pathology
MH  - Food/adverse effects
MH  - Food Hypersensitivity/*diagnosis/*etiology/metabolism
MH  - Humans
MH  - Hypersensitivity/immunology/metabolism/pathology
MH  - Immunity, Innate
MH  - Immunoglobulin E/immunology
MH  - Inflammatory Bowel Diseases/diagnosis/etiology/metabolism
MH  - Omalizumab/therapeutic use
MH  - Skin/immunology/metabolism/pathology
MH  - Th2 Cells/immunology/metabolism
MH  - Treatment Outcome
OTO - NOTNLM
OT  - eosinophilic esophagitis
OT  - epithelial barrier
OT  - food allergy
OT  - immune response
OT  - immunoglobulin E
EDAT- 2016/01/23 06:00
MHDA- 2017/11/29 06:00
CRDT- 2016/01/23 06:00
PHST- 2016/01/17 00:00 [accepted]
PHST- 2016/01/23 06:00 [entrez]
PHST- 2016/01/23 06:00 [pubmed]
PHST- 2017/11/29 06:00 [medline]
AID - 10.1111/all.12846 [doi]
PST - ppublish
SO  - Allergy. 2016 May;71(5):611-20. doi: 10.1111/all.12846. Epub 2016 Feb 25.