PMID- 26801650
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20161230
IS  - 1552-4531 (Electronic)
IS  - 0748-7304 (Linking)
VI  - 31
IP  - 2
DP  - 2016 Apr
TI  - Suprachiasmatic Nucleus and Subparaventricular Zone Lesions Disrupt Circadian 
      Rhythmicity but Not Light-Induced Masking Behavior in Nile Grass Rats.
PG  - 170-81
LID - 10.1177/0748730415626251 [doi]
AB  - The ventral subparaventricular zone (vSPVZ) receives direct retinal input and 
      influences the daily patterning of activity in rodents, making it a likely 
      candidate for the mediation of acute behavioral responses to light (i.e., 
      masking). We performed chemical lesions aimed at the vSPVZ of diurnal grass rats 
      (Arvicanthis niloticus) using N-methyl-D,L-aspartic acid (NMA), a glutamate 
      agonist. Following NMA lesions, we placed grass rats in various lighting 
      conditions (e.g., 12:12 light-dark, constant dark, constant light); presented a 
      series of light pulses at circadian times (CT) 6, 14, 18, and 22; and placed them 
      in a 7-h ultradian cycle to assess behavioral masking. Extensive bilateral 
      lesions of the vSPVZ disrupted the expression of circadian rhythms of activity 
      and abolished the circadian modulation of masking responses to light, without 
      affecting light-induced masking behavior per se. We also found that in diurnal 
      grass rats, NMA was capable of destroying not only neurons of the vSPVZ but also 
      those of the suprachiasmatic nucleus (SCN), even though excitotoxins have been 
      ineffective at destroying cells within the SCN of nocturnal rodents. The 
      vulnerability of the grass rat's SCN to NMA toxicity raises the possibility of a 
      difference in density of receptors for glutamate between nocturnal and diurnal 
      species. In cases in which damage extended to the SCN, masking responses to light 
      were present and similar to those displayed by animals with damage restricted to 
      the vSPVZ. Thus, extensive bilateral lesions of the SCN and vSPVZ disrupted the 
      expression of circadian rhythms without affecting acute responses to light in a 
      diurnal species. Our present and previous results suggest that retinorecipient 
      brain areas other than the SCN or vSPVZ, such as the intergeniculate leaflet or 
      olivary pretectal nucleus, may be responsible for the mediation of masking 
      responses to light in the diurnal grass rat.
CI  - (c) 2016 The Author(s).
FAU - Gall, Andrew J
AU  - Gall AJ
AD  - Department of Psychology, Hope College, Holland, MI gall@hope.edu.
FAU - Shuboni, Dorela D
AU  - Shuboni DD
AD  - Department of Radiology, Michigan State University, East Lansing, MI.
FAU - Yan, Lily
AU  - Yan L
AD  - Department of Psychology and Neuroscience Program, Michigan State University, 
      East Lansing, MI.
FAU - Nunez, Antonio A
AU  - Nunez AA
AD  - Department of Psychology and Neuroscience Program, Michigan State University, 
      East Lansing, MI.
FAU - Smale, Laura
AU  - Smale L
AD  - Department of Psychology and Neuroscience Program, Michigan State University, 
      East Lansing, MI.
LA  - eng
GR  - F32 NS083360-01/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20160122
PL  - United States
TA  - J Biol Rhythms
JT  - Journal of biological rhythms
JID - 8700115
RN  - 0 (Excitatory Amino Acid Agonists)
RN  - 0 (Proto-Oncogene Proteins c-fos)
RN  - 6384-92-5 (N-Methylaspartate)
SB  - IM
MH  - Animals
MH  - Brain/drug effects/*physiology
MH  - *Circadian Rhythm
MH  - Excitatory Amino Acid Agonists/pharmacology
MH  - *Light
MH  - N-Methylaspartate/pharmacology
MH  - Neurons/drug effects/pathology
MH  - Photoperiod
MH  - Proto-Oncogene Proteins c-fos
MH  - Rats
MH  - Suprachiasmatic Nucleus/drug effects/pathology/*physiology
OTO - NOTNLM
OT  - diurnality
OT  - grass rat
OT  - lesions
OT  - masking
OT  - subparaventricular zone
OT  - suprachiasmatic nucleus
EDAT- 2016/01/24 06:00
MHDA- 2016/12/15 06:00
CRDT- 2016/01/24 06:00
PHST- 2016/01/24 06:00 [entrez]
PHST- 2016/01/24 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
AID - 0748730415626251 [pii]
AID - 10.1177/0748730415626251 [doi]
PST - ppublish
SO  - J Biol Rhythms. 2016 Apr;31(2):170-81. doi: 10.1177/0748730415626251. Epub 2016 
      Jan 22.