PMID- 26802511 OWN - NLM STAT- MEDLINE DCOM- 20161213 LR - 20161230 IS - 1873-2747 (Electronic) IS - 0361-9230 (Linking) VI - 121 DP - 2016 Mar TI - Music exposure improves spatial cognition by enhancing the BDNF level of dorsal hippocampal subregions in the developing rats. PG - 131-7 LID - S0361-9230(16)30009-0 [pii] LID - 10.1016/j.brainresbull.2016.01.009 [doi] AB - Previous research has shown that dorsal hippocampus plays an important role in spatial memory process. Music exposure can enhance brain-derived neurotrophic factor (BDNF) expression level in dorsal hippocampus (DH) and thus enhance spatial cognition ability. But whether music experience may affect different subregions of DH in the same degree remains unclear. Here, we studied the effects of exposure to Mozart K.448 on learning behavior in developing rats using the classical Morris water maze task. The results showed that early music exposure could enhance significantly learning performance of the rats in the water maze test. Meanwhile, the BDNF/TrkB level of dorsal hippocampus CA3 (dCA3) and dentate gyrus (dDG) was significantly enhanced in rats exposed to Mozart music as compared to those without music exposure. In contrast, the BDNF/TrkB level of dorsal hippocampus CA1 (dCA1) was not affected. The results suggest that the spatial memory improvement by music exposure in rats may be associated with the enhanced BDNF/TrkB level of dCA3 and dDG. CI - Copyright (c) 2016 Elsevier Inc. All rights reserved. FAU - Xing, Yingshou AU - Xing Y AD - Key Laboratory for NeuroInformation of Ministry of Education, Center for Information in Medicine, University of Electronic Science and Technology of China, Chengdu 610054, China; School of Electronic Information Engineering of Yangtze Normal University, Chongqing FuLing, 408100, China. FAU - Chen, Wenxi AU - Chen W AD - Key Laboratory for NeuroInformation of Ministry of Education, Center for Information in Medicine, University of Electronic Science and Technology of China, Chengdu 610054, China. FAU - Wang, Yanran AU - Wang Y AD - Key Laboratory for NeuroInformation of Ministry of Education, Center for Information in Medicine, University of Electronic Science and Technology of China, Chengdu 610054, China. FAU - Jing, Wei AU - Jing W AD - Key Laboratory for NeuroInformation of Ministry of Education, Center for Information in Medicine, University of Electronic Science and Technology of China, Chengdu 610054, China. FAU - Gao, Shan AU - Gao S AD - Key Laboratory for NeuroInformation of Ministry of Education, Center for Information in Medicine, University of Electronic Science and Technology of China, Chengdu 610054, China. FAU - Guo, Daqing AU - Guo D AD - Key Laboratory for NeuroInformation of Ministry of Education, Center for Information in Medicine, University of Electronic Science and Technology of China, Chengdu 610054, China. FAU - Xia, Yang AU - Xia Y AD - Key Laboratory for NeuroInformation of Ministry of Education, Center for Information in Medicine, University of Electronic Science and Technology of China, Chengdu 610054, China. Electronic address: xiayang@uestc.edu.cn. FAU - Yao, Dezhong AU - Yao D AD - Key Laboratory for NeuroInformation of Ministry of Education, Center for Information in Medicine, University of Electronic Science and Technology of China, Chengdu 610054, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20160121 PL - United States TA - Brain Res Bull JT - Brain research bulletin JID - 7605818 RN - 0 (Brain-Derived Neurotrophic Factor) RN - EC 2.7.10.1 (Receptor, trkB) SB - IM MH - Acoustic Stimulation MH - Age Factors MH - Aging MH - Analysis of Variance MH - Animals MH - Animals, Newborn MH - Brain-Derived Neurotrophic Factor/*metabolism MH - Cognition/*physiology MH - Female MH - Fornix, Brain/*growth & development/*metabolism MH - Gene Expression Regulation, Developmental/*physiology MH - Male MH - Maze Learning MH - *Music MH - Rats MH - Rats, Sprague-Dawley MH - Receptor, trkB/metabolism MH - Spatial Learning/physiology OTO - NOTNLM OT - BDNF/TrkB OT - Cognitive ability OT - Hippocampal subregion OT - Mozart music EDAT- 2016/01/24 06:00 MHDA- 2016/12/15 06:00 CRDT- 2016/01/24 06:00 PHST- 2015/10/29 00:00 [received] PHST- 2015/12/19 00:00 [revised] PHST- 2016/01/18 00:00 [accepted] PHST- 2016/01/24 06:00 [entrez] PHST- 2016/01/24 06:00 [pubmed] PHST- 2016/12/15 06:00 [medline] AID - S0361-9230(16)30009-0 [pii] AID - 10.1016/j.brainresbull.2016.01.009 [doi] PST - ppublish SO - Brain Res Bull. 2016 Mar;121:131-7. doi: 10.1016/j.brainresbull.2016.01.009. Epub 2016 Jan 21.