PMID- 26803388
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20190616
IS  - 1872-7654 (Electronic)
IS  - 0301-2115 (Linking)
VI  - 198
DP  - 2016 Mar
TI  - Elastosonographic evaluation of patients with a sonographic finding of thickened 
      endometrium.
PG  - 105-109
LID - S0301-2115(16)00019-1 [pii]
LID - 10.1016/j.ejogrb.2016.01.017 [doi]
AB  - OBJECTIVE: To evaluate if elastosonography of the endometrium can differ between 
      normal endometrial tissue and abnormal pathology. STUDY DESIGN: One hundred and 
      six women with a sonographic finding of thickened endometrium were enrolled in 
      this study. All patients underwent B-mode scanning and elastosonography, 
      performed by the same operator who was blinded to the study design. After 
      sonographic evaluation, all patients underwent endometrial tissue sampling via 
      dilatation and curettage. Histopathological results indicated that 22 patients 
      had endometrial hyperplasia, 20 patients had endometrial polyps, and 64 patients 
      had normal pathology results, with or without abnormal uterine bleeding. Groups 
      were formed according to histopathological results, and ultrasonographic findings 
      (strain ratio, endometrial thickness) were compared. RESULTS: Median age was 46 
      [interquartile range (IQR) 4] years, 37 (IQR 10) years and 36 (IQR 10) years for 
      the endometrial hyperplasia, endometrial polyps and normal pathology groups, 
      respectively. Median age of the endometrial hyperplasia group was significantly 
      higher compared with the endometrial polyps and normal pathology groups 
      (p<0.001). Median parity was 3 (IQR 2), 2 (IQR 1) and 3 (IQR 1) for the 
      endometrial hyperplasia, endometrial polyps and normal pathology groups, 
      respectively; differences between the groups were not significant (p=0.102). No 
      differences were found between the groups in terms of endometrial thickness 
      (p>0.05). When elastosonographic strain (B/A) ratios were compared between the 
      groups, the endometrial hyperplasia and endometrial polyps groups had 
      significantly lower B/A ratios (higher elasticity) than the normal pathology 
      group (p<0.001). There was no significant difference in B/A ratios between the 
      endometrial hyperplasia and endometrial polyps groups (p>0.05). CONCLUSION: The 
      elasticity of endometrial tissue, measured non-invasively via elastosonography, 
      was similar in women with endometrial polyps and endometrial hyperplasia, but 
      differed significantly compared with women with normal pathology who had a 
      sonographic finding of thickened endometrium and abnormal bleeding as the 
      presenting complaint. According to these results, elastosonography cannot be used 
      as a diagnostic tool to differentiate between endometrial hyperplasia and 
      endometrial polyps. However, elastosonography can be used to differentiate 
      between pathological endometrial changes and normal endometrium in patients 
      presenting with a sonographic finding of thickened endometrium.
CI  - Copyright (c) 2016 Elsevier Ireland Ltd. All rights reserved.
FAU - Gultekin, I B
AU  - Gultekin IB
AD  - Dr. Sami Ulus Women's and Children's Health Training and Research Hospital, 
      Department of Obstetrics and Gynaecology, Ankara, Turkey. Electronic address: 
      burakgultekin@yahoo.com.
FAU - Imamoglu, G I
AU  - Imamoglu GI
AD  - Yiildirim Beyazit Training and Research Hospital, Department of Medical Oncology, 
      Ankara, Turkey.
FAU - Turgal, M
AU  - Turgal M
AD  - Dr. Sami Ulus Women's and Children's Health Training and Research Hospital, 
      Department of Obstetrics and Gynaecology, Ankara, Turkey.
FAU - Gultekin, S
AU  - Gultekin S
AD  - Gazi University School of Medicine, Department of Radiology, Ankara, Turkey.
FAU - Ocal, F D
AU  - Ocal FD
AD  - Dr. Sami Ulus Women's and Children's Health Training and Research Hospital, 
      Department of Obstetrics and Gynaecology, Ankara, Turkey.
FAU - Alkan, A
AU  - Alkan A
AD  - Yildirim Beyazit University, Faculty of Medicine, Department of Biostatistics, 
      Ankara, Turkey.
FAU - Kucukozkan, T
AU  - Kucukozkan T
AD  - Dr. Sami Ulus Women's and Children's Health Training and Research Hospital, 
      Department of Obstetrics and Gynaecology, Ankara, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20160114
PL  - Ireland
TA  - Eur J Obstet Gynecol Reprod Biol
JT  - European journal of obstetrics, gynecology, and reproductive biology
JID - 0375672
SB  - IM
MH  - Adult
MH  - Diagnosis, Differential
MH  - Elasticity Imaging Techniques/*methods
MH  - Endometrial Hyperplasia/*diagnostic imaging
MH  - Endometrial Neoplasms/*diagnostic imaging
MH  - Endometrium/*diagnostic imaging
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Polyps/*diagnostic imaging
MH  - Ultrasonography/*methods
OTO - NOTNLM
OT  - Elastosonography
OT  - Endometrial hyperplasia
OT  - Endometrial polyp
OT  - Thickened endometrium
EDAT- 2016/01/25 06:00
MHDA- 2016/12/15 06:00
CRDT- 2016/01/25 06:00
PHST- 2015/07/15 00:00 [received]
PHST- 2015/10/24 00:00 [revised]
PHST- 2016/01/06 00:00 [accepted]
PHST- 2016/01/25 06:00 [entrez]
PHST- 2016/01/25 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
AID - S0301-2115(16)00019-1 [pii]
AID - 10.1016/j.ejogrb.2016.01.017 [doi]
PST - ppublish
SO  - Eur J Obstet Gynecol Reprod Biol. 2016 Mar;198:105-109. doi: 
      10.1016/j.ejogrb.2016.01.017. Epub 2016 Jan 14.