PMID- 26803642
OWN - NLM
STAT- MEDLINE
DCOM- 20161020
LR  - 20161230
IS  - 1940-6029 (Electronic)
IS  - 1064-3745 (Linking)
VI  - 1390
DP  - 2016
TI  - The Use of MiRNA Antagonists in the Alleviation of Inflammatory Disorders.
PG  - 413-25
LID - 10.1007/978-1-4939-3335-8_24 [doi]
AB  - Toll-like receptors (TLR), a family of pattern-recognition receptors (PRRs) 
      stimulated by pathogen-associated molecular patterns (PAMPs), generate 
      antigen-triggered innate and adaptive immune responses. Recent studies have 
      indicated that several small, regulatory RNAs, called microRNAs (miRNas), are 
      induced by TLR activation in immune cells and that many microRNAs can control the 
      inflammatory process and response to infection by positively or negatively 
      regulating TLR signaling. Among these miRNAs, aberrant microRNA-155 (miR-155) has 
      been implicated in diverse immune processes including the pathogenesis of several 
      autoimmune diseases and cancer. Here, we discuss the role of miR-155 in 
      TLR-mediated and TLR-related immune system regulation. Furthermore, we present 
      our current knowledge of the design, in vivo delivery strategies, and therapeutic 
      efficacy of miR-155 inhibitors in various inflammatory disorders and cancer, 
      including a protocol on the use of miRNA-155 inhibitors in experimental 
      autoimmune encephalomyelitis (EAE).
FAU - Garo, Lucien P
AU  - Garo LP
AD  - Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard 
      Medical School, 77 Avenue Louis Pasteur, Boston, MA, 02115, USA.
FAU - Murugaiyan, Gopal
AU  - Murugaiyan G
AD  - Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard 
      Medical School, 77 Avenue Louis Pasteur, Boston, MA, 02115, USA. 
      mgopal@rics.bwh.harvard.edu.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Methods Mol Biol
JT  - Methods in molecular biology (Clifton, N.J.)
JID - 9214969
RN  - 0 (Liposomes)
RN  - 0 (MicroRNAs)
RN  - 0 (Mirn155 microRNA, mouse)
RN  - 0 (Myelin-Oligodendrocyte Glycoprotein)
RN  - 0 (Peptide Fragments)
RN  - 0 (Toll-Like Receptors)
SB  - IM
MH  - Animals
MH  - Disease Models, Animal
MH  - Encephalomyelitis, Autoimmune, Experimental
MH  - Immune System
MH  - Inflammation/drug therapy/*etiology/*metabolism
MH  - Liposomes
MH  - Mice
MH  - MicroRNAs/*antagonists & inhibitors/*genetics
MH  - Myelin-Oligodendrocyte Glycoprotein/chemistry/immunology
MH  - Peptide Fragments/immunology/pharmacology
MH  - Toll-Like Receptors/*metabolism
OTO - NOTNLM
OT  - Anti-miR
OT  - Dendritic cells
OT  - Experimental autoimmune encephalomyelitis
OT  - LNA
OT  - Locked nucleic acid
OT  - MiR-155
OT  - MicroRNA
OT  - PNA
OT  - Peptide nucleic acid
OT  - T cells
EDAT- 2016/01/25 06:00
MHDA- 2016/10/21 06:00
CRDT- 2016/01/25 06:00
PHST- 2016/01/25 06:00 [entrez]
PHST- 2016/01/25 06:00 [pubmed]
PHST- 2016/10/21 06:00 [medline]
AID - 10.1007/978-1-4939-3335-8_24 [doi]
PST - ppublish
SO  - Methods Mol Biol. 2016;1390:413-25. doi: 10.1007/978-1-4939-3335-8_24.