PMID- 26805557
OWN - NLM
STAT- MEDLINE
DCOM- 20161102
LR  - 20170917
IS  - 1873-3514 (Electronic)
IS  - 0028-3932 (Linking)
VI  - 82
DP  - 2016 Feb
TI  - The temporal structure of resting-state brain activity in the medial prefrontal 
      cortex predicts self-consciousness.
PG  - 161-170
LID - S0028-3932(16)30024-0 [pii]
LID - 10.1016/j.neuropsychologia.2016.01.025 [doi]
AB  - Recent studies have demonstrated an overlap between the neural substrate of 
      resting-state activity and self-related processing in the cortical midline 
      structures (CMS). However, the neural and psychological mechanisms mediating this 
      so-called "rest-self overlap" remain unclear. To investigate the neural 
      mechanisms, we estimated the temporal structure of spontaneous/resting-state 
      activity, e.g. its long-range temporal correlations or self-affinity across time 
      as indexed by the power-law exponent (PLE). The PLE was obtained in resting-state 
      activity in the medial prefrontal cortex (MPFC) and the posterior cingulate 
      cortex (PCC) in 47 healthy subjects by functional magnetic resonance imaging 
      (fMRI). We performed correlation analyses of the PLE and Revised 
      Self-Consciousness Scale (SCSR) scores, which enabled us to access different 
      dimensions of self-consciousness and specified rest-self overlap in a 
      psychological regard. The PLE in the MPFC's resting-state activity correlated 
      with private self-consciousness scores from the SCSR. Conversely, we found no 
      correlation between the PLE and the other subscales of the SCSR (public, social) 
      or between other resting-state measures, including functional connectivity, and 
      the SCSR subscales. This is the first evidence for the association between the 
      scale-free dynamics of resting-state activity in the CMS and the private 
      dimension of self-consciousness. This finding implies the relationship of 
      especially the private dimension of self with the temporal structure of 
      resting-state activity.
CI  - Copyright (c) 2016 Elsevier Ltd. All rights reserved.
FAU - Huang, Zirui
AU  - Huang Z
AD  - Institute of Mental Health Research, University of Ottawa, Ottawa, ON, Canada K1Z 
      7K4. Electronic address: Dr.Zirui.Huang@gmail.com.
FAU - Obara, Natsuho
AU  - Obara N
AD  - Institute of Mental Health Research, University of Ottawa, Ottawa, ON, Canada K1Z 
      7K4; Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada K1H 8M5.
FAU - Davis, Henry Hap 4th
AU  - Davis HH 4th
AD  - Swimming Canada, Calgary, Alberta, Canada T2P 3C5.
FAU - Pokorny, Johanna
AU  - Pokorny J
AD  - Department of Anthropology, University of Toronto, Toronto, ON, Canada M5S 2S2.
FAU - Northoff, Georg
AU  - Northoff G
AD  - Institute of Mental Health Research, University of Ottawa, Ottawa, ON, Canada K1Z 
      7K4; Center for Cognition and Brain Disorders, Hangzhou Normal University, 
      Hangzhou 311121, PR China; Zhejiang Key Laboratory for Research in Assessment of 
      Cognitive Impairments, Hangzhou Normal University, Hangzhou 310015, PR China; 
      Taipei Medical University, Graduate Institute of Humanities in Medicine, Taipei, 
      Taiwan; Taipei Medical University-Shuang Ho Hospital, Brain and Consciousness 
      Research Center, New Taipei City, Taiwan.
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160121
PL  - England
TA  - Neuropsychologia
JT  - Neuropsychologia
JID - 0020713
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Brain Mapping
MH  - Consciousness/*physiology
MH  - Female
MH  - Gyrus Cinguli/physiology
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Neural Pathways/physiology
MH  - Prefrontal Cortex/*physiology
MH  - *Self Concept
MH  - Young Adult
OTO - NOTNLM
OT  - Cortical midline structures
OT  - Resting-state fMRI
OT  - Scale-free brain dynamics
OT  - Self-consciousness
EDAT- 2016/01/26 06:00
MHDA- 2016/11/03 06:00
CRDT- 2016/01/26 06:00
PHST- 2015/08/17 00:00 [received]
PHST- 2015/12/23 00:00 [revised]
PHST- 2016/01/20 00:00 [accepted]
PHST- 2016/01/26 06:00 [entrez]
PHST- 2016/01/26 06:00 [pubmed]
PHST- 2016/11/03 06:00 [medline]
AID - S0028-3932(16)30024-0 [pii]
AID - 10.1016/j.neuropsychologia.2016.01.025 [doi]
PST - ppublish
SO  - Neuropsychologia. 2016 Feb;82:161-170. doi: 
      10.1016/j.neuropsychologia.2016.01.025. Epub 2016 Jan 21.