PMID- 26806738
OWN - NLM
STAT- MEDLINE
DCOM- 20160426
LR  - 20211203
IS  - 1673-4254 (Print)
IS  - 1673-4254 (Linking)
VI  - 36
IP  - 1
DP  - 2016 Jan
TI  - [Expressions of SMG-1, ATM and P53 in laryngeal squamous cell carcinoma and their 
      clinical significance].
PG  - 50-5
AB  - OBJECTIVE: To detect the expression of SMG-1, ATM and P53 in laryngeal squamous 
      cell carcinoma (LSCC) and their correlation with the clinicopathological features 
      and outcomes of the patients. METHODS: Sixty-three specimens of surgically 
      resected LSCC tissues and 30 specimens of adjacent normal tissue were examined 
      for the expressions of ATM, SMG-1 and P53 using immunohistochemistry. The 
      correlation of ATM, SMG-1 and P53 expressions with the clinicopathological 
      factors and their interactions were analyzed. RESULTS: The positive expression 
      rates of SMG-1, ATM and P53 in LSCC were 36.5% (23/63) , 41.3% (26/63) and 57.1% 
      (36/63) respectively, significantly different from those in the adjacent tissue 
      (73.3%, 83.3% and 20.0%, respectively; P<0.05). The expression of SMG-1 in LSCC 
      was positively correlated with the pathological grade and T stage of the tumors 
      (P<0.05), and ATM and P53 were not related to the clinicopathological factors 
      (P>0.05). The 5-year survival rate of patients negative for SMG-1 expression was 
      significantly higher than that of SMG-1-positive patients (P<0.05). The 
      expression of SMG-1 was negatively correlated with that of P53 (r=-0.476, 
      P<0.01). CONCLUSION: SMG-1, ATM and P53 are closely related to the occurrence of 
      LSCC. SMG-1 expression is an important factor associated with the 
      clinicopathological features and prognosis of LSCC patients, and may play an 
      important role in the development of LSCC by regulating P53 expression.
FAU - Zhou, Xuejun
AU  - Zhou X
AD  - Department of Otolaryngology, Zhujiang Hospital, Southern Medical University, 
      Guangzhou 510280, China.E-mail: zxjclp@sina.com.
FAU - Wang, Xiaofeng
AU  - Wang X
FAU - Feng, Yongjun
AU  - Feng Y
FAU - Xie, Minqiang
AU  - Xie M
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Nan Fang Yi Ke Da Xue Xue Bao
JT  - Nan fang yi ke da xue xue bao = Journal of Southern Medical University
JID - 101266132
RN  - 0 (TP53 protein, human)
RN  - 0 (Tumor Suppressor Protein p53)
RN  - EC 2.7.11.1 (ATM protein, human)
RN  - EC 2.7.11.1 (Ataxia Telangiectasia Mutated Proteins)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
RN  - EC 2.7.11.1 (SMG1 protein, human)
SB  - IM
MH  - Ataxia Telangiectasia Mutated Proteins/genetics/*metabolism
MH  - Carcinoma, Squamous Cell/genetics/*metabolism
MH  - Humans
MH  - Immunohistochemistry
MH  - Laryngeal Neoplasms/genetics/*metabolism
MH  - Lymphatic Metastasis
MH  - Phosphatidylinositol 3-Kinases/genetics/*metabolism
MH  - Prognosis
MH  - Protein Serine-Threonine Kinases
MH  - Survival Rate
MH  - Tumor Suppressor Protein p53/genetics/*metabolism
EDAT- 2016/01/26 06:00
MHDA- 2016/04/27 06:00
CRDT- 2016/01/26 06:00
PHST- 2016/01/26 06:00 [entrez]
PHST- 2016/01/26 06:00 [pubmed]
PHST- 2016/04/27 06:00 [medline]
PST - ppublish
SO  - Nan Fang Yi Ke Da Xue Xue Bao. 2016 Jan;36(1):50-5.