PMID- 26807166
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160125
LR  - 20201001
IS  - 1943-8141 (Print)
IS  - 1943-8141 (Electronic)
IS  - 1943-8141 (Linking)
VI  - 7
IP  - 11
DP  - 2015
TI  - Effects of human umbilical cord mesenchymal stem cell transplantation combined 
      with minimally invasive hematoma aspiration on intracerebral hemorrhage in rats.
PG  - 2176-86
AB  - This study is to investigate the effects of human umbilical cord-mesenchymal stem 
      cells (HUC-MSCs) transplantation combined with minimally invasive hematoma 
      aspiration on neural functional recovery and p53 gene expression in rats with 
      intracerebral hemorrhage (ICH). Collagenase type-IV was injected to the caudate 
      nucleus of the rats to make ICH models. One hundred and twenty Sprague-Dawley 
      rats with successful modeling were randomly divided into 4 groups, including the 
      ICH group, hematoma aspiration group, HUC-MSCs transplantation group and HUC-MSCs 
      transplantation combined with hematoma aspiration group (combination group). 
      Neural functional status of the rats was assessed by modified neurological 
      severity score (mNSS). Expression of p53 in the cerebral tissues surrounding ICH 
      was detected by immunohistochemical assays. The scores of mNSS and the expression 
      of p53 gene in the hematoma aspiration group, the HUC-MSCs transplantation group 
      and the combination group were significantly lower than those in the ICH group at 
      each indicated time point (p < 0.05). Intriguingly, mNSS scores and p53 
      expression in the combination group were significantly lower than those in the 
      hematoma aspiration group on day 7, 14 and 30 (p < 0.05), and significantly lower 
      than those in the HUC-MSCs transplantation group on day 14 and 30 (p < 0.05). 
      HUC-MSCs transplantation combined with minimally invasive hematoma aspiration is 
      more effective than either therapy alone in rats with ICH and could distinctly 
      reduce the damage of nerve cells.
FAU - Zhang, Qinghua
AU  - Zhang Q
AD  - Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong 
      University Jinan 250021, P.R. China.
FAU - Shang, Xiao
AU  - Shang X
AD  - Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong 
      University Jinan 250021, P.R. China.
FAU - Hao, Maolin
AU  - Hao M
AD  - Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong 
      University Jinan 250021, P.R. China.
FAU - Zheng, Maoyong
AU  - Zheng M
AD  - Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong 
      University Jinan 250021, P.R. China.
FAU - Li, Yanxia
AU  - Li Y
AD  - Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong 
      University Jinan 250021, P.R. China.
FAU - Liang, Zhigang
AU  - Liang Z
AD  - Department of Neurology, Affiliated Yantai Yuhuangding Hospital of Qingdao 
      University Medical College Yantai 264000, P.R. China.
FAU - Cui, Yuanxiao
AU  - Cui Y
AD  - Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong 
      University Jinan 250021, P.R. China.
FAU - Liu, Zhenhua
AU  - Liu Z
AD  - Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong 
      University Jinan 250021, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20151115
PL  - United States
TA  - Am J Transl Res
JT  - American journal of translational research
JID - 101493030
PMC - PMC4697698
OTO - NOTNLM
OT  - Human umbilical cord-mesenchymal stem cell transplantation
OT  - intracerebral hemorrhage
OT  - minimally invasive hematoma aspiration
OT  - p53
OT  - rats
EDAT- 2016/01/26 06:00
MHDA- 2016/01/26 06:01
PMCR- 2015/11/15
CRDT- 2016/01/26 06:00
PHST- 2015/03/18 00:00 [received]
PHST- 2015/10/13 00:00 [accepted]
PHST- 2016/01/26 06:00 [entrez]
PHST- 2016/01/26 06:00 [pubmed]
PHST- 2016/01/26 06:01 [medline]
PHST- 2015/11/15 00:00 [pmc-release]
PST - epublish
SO  - Am J Transl Res. 2015 Nov 15;7(11):2176-86. eCollection 2015.