PMID- 26807201
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160125
LR  - 20201001
IS  - 1947-6019 (Print)
IS  - 1947-6027 (Electronic)
IS  - 1947-6019 (Linking)
VI  - 6
IP  - 11-12
DP  - 2015 Nov
TI  - Tumor cell expression of MMP3 as a prognostic factor for poor survival in 
      pancreatic, pulmonary, and mammary carcinoma.
PG  - 480-9
AB  - Breast, lung, and pancreatic cancers collectively represent one third of all 
      diagnosed tumors and are responsible for almost 40% of overall cancer mortality. 
      Despite improvements in current treatments, efforts to develop more specific 
      therapeutic options are warranted. Here we identify matrix metalloproteinase 3 
      (MMP3) as a potential target within all three of these tumor types. MMP3 has 
      previously been shown to induce expression of Rac1b, a tumorigenic splice isoform 
      of Rac1. In this study we find that MMP3 and Rac1b proteins are both strongly 
      expressed by the tumor cells of all three tumor types and that expression of MMP3 
      protein is prognostic of poor survival in pancreatic cancer patients. We also 
      find that MMP3 gene expression can serve as a prognostic marker for patient 
      survival in breast and lung cancer. These results suggest an oncogenic MMP3-Rac1b 
      signaling axis as a driver of tumor progression in three common poor prognosis 
      tumor types, further suggesting that new therapies to target these pathways could 
      have substantial therapeutic benefit.
FAU - Mehner, Christine
AU  - Mehner C
AD  - Department of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA.
FAU - Miller, Erin
AU  - Miller E
AD  - Department of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA.
FAU - Nassar, Aziza
AU  - Nassar A
AD  - Department of Pathology, Mayo Clinic, Jacksonville, FL, USA.
FAU - Bamlet, William R
AU  - Bamlet WR
AD  - Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
FAU - Radisky, Evette S
AU  - Radisky ES
AD  - Department of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA.
FAU - Radisky, Derek C
AU  - Radisky DC
AD  - Department of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA.
LA  - eng
GR  - P50 CA102701/CA/NCI NIH HHS/United States
GR  - P50 CA116201/CA/NCI NIH HHS/United States
GR  - R01 CA154387/CA/NCI NIH HHS/United States
GR  - R01 CA187692/CA/NCI NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Genes Cancer
JT  - Genes & cancer
JID - 101516546
PMC - PMC4701227
OTO - NOTNLM
OT  - IHC
OT  - MMP3
OT  - breast cancer
OT  - lung cancer
OT  - pancreatic cancer
COIS- CONFLICTS OF INTEREST There is no conflict of interest.
EDAT- 2016/01/26 06:00
MHDA- 2016/01/26 06:01
PMCR- 2015/11/01
CRDT- 2016/01/26 06:00
PHST- 2016/01/26 06:00 [entrez]
PHST- 2016/01/26 06:00 [pubmed]
PHST- 2016/01/26 06:01 [medline]
PHST- 2015/11/01 00:00 [pmc-release]
AID - 90 [pii]
AID - 10.18632/genesandcancer.90 [doi]
PST - ppublish
SO  - Genes Cancer. 2015 Nov;6(11-12):480-9. doi: 10.18632/genesandcancer.90.