PMID- 26807336
OWN - NLM
STAT- MEDLINE
DCOM- 20161020
LR  - 20210109
IS  - 2162-3279 (Electronic)
VI  - 5
IP  - 12
DP  - 2015 Dec
TI  - Neural correlates of different self domains.
PG  - e00409
LID - 10.1002/brb3.409 [doi]
LID - e00409
AB  - INTRODUCTION: The neural substrates of states devoted to processing self-related 
      information ("self-related states") remain not fully elucidated. Besides the 
      complexity of the problem, there is evidence suggesting that self-related states 
      vary according to the information domain being considered. Here, we investigated 
      brain correlates for self-related states concerning historical aspects of one's 
      life (autobiographical self), and one's ongoing body status (core self). We 
      focused on memory-related regions, body-related regions, CMSs (cortical midline 
      structures), and ICs (insular cortices). METHODS: This was a block-design fMRI 
      study contrasting brain activity for core self (interoception and exteroception) 
      and autobiographical self (personality traits and biographic facts) information 
      domains. It involved 19 participants, who answered questions about each domain 
      (four conditions). RESULTS: All conditions appeared to engage the regions of 
      interest. Nonetheless, autobiographical self compared with core self showed 
      greater activity in memory-related regions (e.g., hippocampus), MPFC (medial 
      prefrontal cortex), superior PMC (posteromedial cortex), and anterior ICs. Core 
      self compared with autobiographical self was associated with greater activity in 
      body-related regions (e.g., somatosensory cortices, and EBA [extrastriate body 
      area]), superior PMC, and posterior ICs. In addition, (1) facts compared with 
      traits showed greater activity in body-related regions, memory-related regions, 
      MPFC, and PMC; (2) traits compared with facts were associated with greater 
      activity in the posterior part of the anterior cingulate cortex; (3) 
      interoception compared with exteroception was associated with greater activity in 
      body-related regions (e.g. postcentral gyrus), memory-related regions, MPFC, 
      inferior PMC and ICs; (4) exteroception compared with interoception showed 
      greater activity in some body-related regions (e.g., premotor cortices and EBA) 
      and superior PMC. CONCLUSIONS: The results support the notion that the neural 
      correlates of self-related states depend on the information domain. Those states 
      seem distinguishable in terms of activity in memory-related and body-related 
      regions, and activity in regions that have been associated with self processes 
      (CMSs and the ICs).
FAU - Araujo, Helder F
AU  - Araujo HF
AD  - Brain and Creativity Institute University of Southern California Los Angeles 
      California; Neuroscience Graduate Program University of Southern California Los 
      Angeles California; Graduate Program in Areas of Basic and Applied Biology 
      University of Oporto Oporto Portugal.
FAU - Kaplan, Jonas
AU  - Kaplan J
AD  - Brain and Creativity Institute University of Southern California Los Angeles 
      California.
FAU - Damasio, Hanna
AU  - Damasio H
AD  - Brain and Creativity Institute University of Southern California Los Angeles 
      California.
FAU - Damasio, Antonio
AU  - Damasio A
AD  - Brain and Creativity Institute University of Southern California Los Angeles 
      California.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151021
PL  - United States
TA  - Brain Behav
JT  - Brain and behavior
JID - 101570837
SB  - IM
MH  - Brain/*physiology
MH  - Brain Mapping
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - *Memory, Episodic
MH  - Neuropsychological Tests
MH  - Perception/*physiology
MH  - Personality
MH  - Proprioception/*physiology
MH  - Reaction Time
MH  - *Self Concept
MH  - Young Adult
PMC - PMC4714646
OTO - NOTNLM
OT  - Autobiographical self
OT  - core self
OT  - exteroception
OT  - interoception
OT  - memory
OT  - self
EDAT- 2016/01/26 06:00
MHDA- 2016/10/21 06:00
PMCR- 2015/10/21
CRDT- 2016/01/26 06:00
PHST- 2015/04/07 00:00 [received]
PHST- 2015/08/21 00:00 [revised]
PHST- 2015/09/06 00:00 [accepted]
PHST- 2016/01/26 06:00 [entrez]
PHST- 2016/01/26 06:00 [pubmed]
PHST- 2016/10/21 06:00 [medline]
PHST- 2015/10/21 00:00 [pmc-release]
AID - BRB3409 [pii]
AID - 10.1002/brb3.409 [doi]
PST - epublish
SO  - Brain Behav. 2015 Oct 21;5(12):e00409. doi: 10.1002/brb3.409. eCollection 2015 
      Dec.