PMID- 26808160
OWN - NLM
STAT- MEDLINE
DCOM- 20160815
LR  - 20220330
IS  - 1365-3083 (Electronic)
IS  - 0300-9475 (Linking)
VI  - 83
IP  - 4
DP  - 2016 Apr
TI  - Effects of Ageing on the Immune System: Infants to Elderly.
PG  - 255-66
LID - 10.1111/sji.12413 [doi]
AB  - Physiological ageing is accompanied by decline in immune system function and 
      immune alteration during ageing increases susceptibility to infections. We 
      retrospectively analysed the data for complete blood count (CBC) and lymphocyte 
      subsets from infant to elderly age groups to determine changes during ageing. 
      Data from dual-platform flow cytometry and CBC were analysed to determine the 
      percentage (%) and absolute cell counts (Abs) of peripheral blood lymphocyte 
      subsets (CD3, CD4, CD8, CD19 and CD56+16+ cells) in infants (1 month to 1 year), 
      children (1 year to 6 years), adolescents (12 years to 18 years), adults (21 
      years to 50) and elderly (70 years to 92 years). Differences in plasma cytokine 
      levels in adults and elderly were also analysed using Randox system. Comparisons 
      among age groups from infants through adults revealed progressive declines in the 
      percentage of total lymphocytes and absolute numbers of T and B cells. The NK 
      cells declined from infancy to adulthood but increased in elderly participants. 
      The percentages of T cells increased with age from infant to adulthood and then 
      declined. Pro-inflammatory cytokines, TNF-alpha and IL-6, were higher in elderly 
      people compared to adults. The elderly group had significantly higher levels of 
      monocyte chemoattractant protein-1 (MCP-1) and lower levels of epidermal growth 
      factor (EGF) compared to adults. Our findings confirm and extend earlier reports 
      on age-related changes in lymphocyte subpopulations and data generated from this 
      study is useful for clinicians and researchers, patient management in various age 
      groups for the interpretation of disease-related changes, as well as 
      therapy-dependent alterations.
CI  - (c) 2016 The Foundation for the Scandinavian Journal of Immunology.
FAU - Valiathan, R
AU  - Valiathan R
AD  - University of Miami - Miller School of Medicine, Miami, FL, USA.
FAU - Ashman, M
AU  - Ashman M
AD  - University of Miami - Miller School of Medicine, Miami, FL, USA.
FAU - Asthana, D
AU  - Asthana D
AD  - University of Miami - Miller School of Medicine, Miami, FL, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Scand J Immunol
JT  - Scandinavian journal of immunology
JID - 0323767
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Cytokines)
RN  - 0 (IL6 protein, human)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 62229-50-9 (Epidermal Growth Factor)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Aging/*immunology/physiology
MH  - B-Lymphocytes/cytology
MH  - *Blood Cell Count
MH  - Chemokine CCL2/blood
MH  - Child
MH  - Child, Preschool
MH  - Cytokines/*blood
MH  - Epidermal Growth Factor/blood
MH  - Female
MH  - Flow Cytometry
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Interleukin-6/blood
MH  - Killer Cells, Natural/cytology
MH  - *Lymphocyte Count
MH  - Lymphocyte Subsets/*cytology
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - T-Lymphocytes/cytology
MH  - Tumor Necrosis Factor-alpha/blood
MH  - Young Adult
EDAT- 2016/01/26 06:00
MHDA- 2016/08/16 06:00
CRDT- 2016/01/26 06:00
PHST- 2015/07/31 00:00 [received]
PHST- 2016/01/15 00:00 [accepted]
PHST- 2016/01/26 06:00 [entrez]
PHST- 2016/01/26 06:00 [pubmed]
PHST- 2016/08/16 06:00 [medline]
AID - 10.1111/sji.12413 [doi]
PST - ppublish
SO  - Scand J Immunol. 2016 Apr;83(4):255-66. doi: 10.1111/sji.12413.