PMID- 26808640
OWN - NLM
STAT- MEDLINE
DCOM- 20160804
LR  - 20220317
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 616
DP  - 2016 Mar 11
TI  - The effects of an intraperitoneal single low dose of ketamine in attenuating the 
      postoperative skin/muscle incision and retraction-induced pain related to the 
      inhibition of N-methyl-D-aspartate receptors in the spinal cord.
PG  - 211-7
LID - S0304-3940(15)30328-1 [pii]
LID - 10.1016/j.neulet.2015.12.045 [doi]
AB  - BACKGROUND: Chronic postoperative pain (CPOP) is a common clinical problem which 
      might be related to central sensitization. It has been widely accepted that NMDA 
      (N-methyl-D-aspartate) receptors are among the triggers of central sensitization. 
      Ketamine is a non-competitive NMDA receptor antagonist that is widely used in 
      alleviating postoperative pain, but its effect on CPOP has been rarely reported. 
      In the present study, the skin/muscle incision and retraction (SMIR) model was 
      used to investigate the role of NMDARs in chronic postoperative pain and the 
      effect of an intraperitoneal single low dose ketamine (10mg/kg) of attenuating 
      SMIR-induced CPOP. METHODS: We assessed pain behaviours after a SMIR operation by 
      paw withdrawal threshold (PWMT) and paw withdrawal latency (PWMTL). Western 
      blotting were performed to examine the role of NMDARs in SMIR-induced CPOP and 
      the effect of ketamine on the expression and phosphorylation of NMDARs. RESULTS: 
      The SMIR operation induced long-lasting mechanical hyperalgesia, and the 
      up-regulation of phosphorylated NMDARs and total NMDARs at the spinal level. A 
      single intraperitoneal administration of low dose ketamine (10mg/kg) during 
      surgery alleviated pain behaviors and inhibited the up-regulation of 
      phosphorylated NMDARs and total NMDARs. CONCLUSIONS: Our datas suggested that 
      NMDARs play important roles in SMIR-induced CPOP. A single intraperitoneal low 
      dose of ketamine could attenuate SMIR-induced CPOP, which might be associated 
      with the inhibition of NMDARs. Our finding might provide a new, simple method of 
      addressing CPOP.
CI  - Copyright (c) 2016 Elsevier Ireland Ltd. All rights reserved.
FAU - Shen, Yu
AU  - Shen Y
AD  - Department of Anesthesiology, Affiliated Drum Tower Hospital of Medical 
      Department of Nanjing University, Nanjing, Jiangsu, China. Electronic address: 
      feather0417@sina.com.
FAU - Xu, Li
AU  - Xu L
AD  - Department of Anesthesiology, Affiliated Drum Tower Hospital of Medical 
      Department of Nanjing University, Nanjing, Jiangsu, China. Electronic address: 
      275585794@qq.com.
FAU - Liu, Ming
AU  - Liu M
AD  - Department of Anesthesiology, Affiliated Drum Tower Hospital of Medical 
      Department of Nanjing University, Nanjing, Jiangsu, China. Electronic address: 
      liuming0225@126.com.
FAU - Lei, Yishan
AU  - Lei Y
AD  - Department of Anesthesiology, Affiliated Drum Tower Hospital of Medical 
      Department of Nanjing University, Nanjing, Jiangsu, China. Electronic address: 
      mikunichan@sina.com.
FAU - Gu, Xiaoping
AU  - Gu X
AD  - Department of Anesthesiology, Affiliated Drum Tower Hospital of Medical 
      Department of Nanjing University, Nanjing, Jiangsu, China. Electronic address: 
      13813996903@126.com.
FAU - Ma, Zhengliang
AU  - Ma Z
AD  - Department of Anesthesiology, Affiliated Drum Tower Hospital of Medical 
      Department of Nanjing University, Nanjing, Jiangsu, China. Electronic address: 
      mazhengliang1964@nju.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160122
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Analgesics)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 690G0D6V8H (Ketamine)
SB  - IM
MH  - Analgesics/*administration & dosage
MH  - Animals
MH  - Injections, Intraperitoneal
MH  - Ketamine/*administration & dosage
MH  - Male
MH  - Muscle, Skeletal/surgery
MH  - Pain, Postoperative/*drug therapy
MH  - Rats, Sprague-Dawley
MH  - Receptors, N-Methyl-D-Aspartate/*antagonists & inhibitors/metabolism
MH  - Spinal Cord/*drug effects/metabolism
OTO - NOTNLM
OT  - Central sensitization
OT  - Chronic postoperative pain
OT  - N-methyl-d-aspartate
OT  - Skin/muscle incision and retraction
EDAT- 2016/01/26 06:00
MHDA- 2016/08/05 06:00
CRDT- 2016/01/26 06:00
PHST- 2015/07/19 00:00 [received]
PHST- 2015/11/18 00:00 [revised]
PHST- 2015/12/17 00:00 [accepted]
PHST- 2016/01/26 06:00 [entrez]
PHST- 2016/01/26 06:00 [pubmed]
PHST- 2016/08/05 06:00 [medline]
AID - S0304-3940(15)30328-1 [pii]
AID - 10.1016/j.neulet.2015.12.045 [doi]
PST - ppublish
SO  - Neurosci Lett. 2016 Mar 11;616:211-7. doi: 10.1016/j.neulet.2015.12.045. Epub 
      2016 Jan 22.