PMID- 26808961
OWN - NLM
STAT- MEDLINE
DCOM- 20160711
LR  - 20190222
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 11
IP  - 1
DP  - 2016
TI  - Comparison of Optical Coherence Tomography Measurement Reproducibility between 
      Children and Adults.
PG  - e0147448
LID - 10.1371/journal.pone.0147448 [doi]
LID - e0147448
AB  - PURPOSE: To compare the reproducibility of SD-OCT (spectral-domain optical 
      coherence tomography) measurements of RNFL (retinal nerve fiber layer) and 
      macular thickness between children and adults. METHODS: Seventy-one eyes of 71 
      children and 71 eyes of 71 adults were prospectively enrolled. RNFL and macular 
      thicknesses were measured by one operator, with a brief rest between 
      measurements. The two measurements were obtained using the eye tracking and 
      retest function of Spectralis SD-OCT. Reproducibility was evaluated with 
      reference to COVs (coefficients of variation) and ICCs (intraclass correlation 
      coefficients). The ICC values of the RNFL and macular thicknesses were compared, 
      respectively between the two groups, by Fisher's z-test. RESULTS: The RNFL and 
      macular thicknesses did not differ between the two groups. The COVs of the RNFL 
      measurements ranged from 0.945 to 4.531% in the children group and from 0.496 to 
      1.391% in the adults group. In most of the RNFL sectors, the ICCs of the children 
      group (range: 0.731-0.987) were significantly lower than those of the adults 
      group (range: 0.986-0.993). The COVs of the macular measurements ranged from 
      0.496 to 1.157% in the children group and from 0.275 to 0.656% in the adults 
      group. The ICCs (range: 0.860-0.974) in the children group, significantly lower 
      than for the adults (range: 0.989-0.995), in all of the macular sectors. 
      CONCLUSIONS: The reproducibility of SD-OCT RNFL and macular measurements for 
      children was excellent, albeit statistically lower than that for adults.
FAU - Chung, Ho Kyung
AU  - Chung HK
AD  - Department of Ophthalmology, Seoul National University College of Medicine, 
      Seoul, Korea.
AD  - Department of Ophthalmology, Seoul National University Boramae Hospital, Seoul, 
      Korea.
FAU - Han, Young Keun
AU  - Han YK
AD  - Department of Ophthalmology, Seoul National University College of Medicine, 
      Seoul, Korea.
AD  - Department of Ophthalmology, Seoul National University Boramae Hospital, Seoul, 
      Korea.
FAU - Oh, Sohee
AU  - Oh S
AD  - Department of Biostatistics, Seoul National University Boramae Hospital, Seoul, 
      Korea.
FAU - Kim, Seok Hwan
AU  - Kim SH
AD  - Department of Ophthalmology, Seoul National University College of Medicine, 
      Seoul, Korea.
AD  - Department of Ophthalmology, Seoul National University Boramae Hospital, Seoul, 
      Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160125
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Child
MH  - Female
MH  - Humans
MH  - Intraocular Pressure/physiology
MH  - Male
MH  - Middle Aged
MH  - Nerve Fibers/*pathology
MH  - Reproducibility of Results
MH  - Retina/*pathology
MH  - Tomography, Optical Coherence/*standards
MH  - Young Adult
PMC - PMC4726508
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2016/01/26 06:00
MHDA- 2016/07/12 06:00
PMCR- 2016/01/25
CRDT- 2016/01/26 06:00
PHST- 2015/06/11 00:00 [received]
PHST- 2016/01/03 00:00 [accepted]
PHST- 2016/01/26 06:00 [entrez]
PHST- 2016/01/26 06:00 [pubmed]
PHST- 2016/07/12 06:00 [medline]
PHST- 2016/01/25 00:00 [pmc-release]
AID - PONE-D-15-25639 [pii]
AID - 10.1371/journal.pone.0147448 [doi]
PST - epublish
SO  - PLoS One. 2016 Jan 25;11(1):e0147448. doi: 10.1371/journal.pone.0147448. 
      eCollection 2016.