PMID- 26809410
OWN - NLM
STAT- MEDLINE
DCOM- 20160401
LR  - 20181202
IS  - 0385-0684 (Print)
IS  - 0385-0684 (Linking)
VI  - 42 Suppl 1
DP  - 2015 Dec
TI  - [Clinical Utility of Tapentadol].
PG  - 48-50
AB  - Tapentadol(TP)is a new strong opioid analgesicthat has both m-opioid 
      receptor(MOR)effects and norepinephrine reuptake inhibitor(NRI)effects. In 
      comparison with the existing strong opioid analgesics, the mechanism of action 
      suitable for palliation of neuropathic pain is expected to be better for TP. The 
      analgesic effect and side effects of this drug were tested in 10 cases of 
      exacerbation of neuropathic pain at our hospital, and the sedative response rate 
      was 70%. The main side effects were somnolence 44.4%, nausea 33.4%, and 
      constipation 11.1%. The side effects on the digestive system were considered 
      minimal. Although it is speculated that opioids would be useful as an outpatient 
      treatment, few case reports are available regarding their use for cancer pain; 
      therefore, further investigation is necessary. Generally, numerous social issues 
      that would increase the likelihood of drug adherence failure must be addressed in 
      order to expand the use of strong opioid analgesics such as TP. Both the patients 
      and the healthcare worker should be involved when addressing these issues in 
      Japan, and the measures should include instructions for appropriate reporting and 
      for using such drugs.
FAU - Kanazawa, Kunihito
AU  - Kanazawa K
AD  - Kanamecho Hospital.
FAU - Yoshizawa, Akitaka
AU  - Yoshizawa A
FAU - Ishigure, Hiroyuki
AU  - Ishigure H
FAU - Shimoda, Atsuko
AU  - Shimoda A
FAU - Hiratsuka, Rie
AU  - Hiratsuka R
FAU - Ikeda, Hiroyoshi
AU  - Ikeda H
FAU - Yoshizawa, Takayuki
AU  - Yoshizawa T
LA  - jpn
PT  - Journal Article
PL  - Japan
TA  - Gan To Kagaku Ryoho
JT  - Gan to kagaku ryoho. Cancer & chemotherapy
JID - 7810034
RN  - 0 (Analgesics, Opioid)
RN  - 0 (Phenols)
RN  - H8A007M585 (Tapentadol)
SB  - IM
MH  - Aged
MH  - Analgesics, Opioid/adverse effects/*therapeutic use
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neoplasms/complications/*therapy
MH  - *Pain/etiology
MH  - *Pain Management
MH  - Pain Measurement
MH  - *Palliative Care
MH  - Phenols/adverse effects/*therapeutic use
MH  - Tapentadol
EDAT- 2016/01/27 06:00
MHDA- 2016/04/02 06:00
CRDT- 2016/01/27 06:00
PHST- 2016/01/27 06:00 [entrez]
PHST- 2016/01/27 06:00 [pubmed]
PHST- 2016/04/02 06:00 [medline]
PST - ppublish
SO  - Gan To Kagaku Ryoho. 2015 Dec;42 Suppl 1:48-50.