PMID- 26810469
OWN - NLM
STAT- MEDLINE
DCOM- 20170323
LR  - 20181202
IS  - 1532-2653 (Electronic)
IS  - 0967-5868 (Linking)
VI  - 28
DP  - 2016 Jun
TI  - Higher expression of monocyte chemoattractant protein 1 and its receptor in brain 
      tissue of intractable epilepsy patients.
PG  - 134-40
LID - S0967-5868(15)00649-9 [pii]
LID - 10.1016/j.jocn.2015.07.033 [doi]
AB  - We aimed to explore the pathogenesis of monocyte chemoattractant protein-1 (MCP1) 
      and CC chemokine receptor 2 (CCR2) in brain tissue of patients with intractable 
      epilepsy (IE). Hippocampi or temporal lobe tissues were obtained from 40 patients 
      with IE and five patients without IE who had undergone surgical decompression and 
      debridement. The levels of MCP1 and CCR2 were evaluated using 
      immunohistochemistry. Pearson correlation analysis was employed to evaluate the 
      correlation between levels of MCP1 and CCR2 in IE with or without hippocampal 
      sclerosis (HS) and the disease duration, along with age. Higher levels of MCP1 
      (11.68+/-4.68% versus 1.72+/-1.54%) and CCR2 (11.54+/-4.65% versus 1.52+/-1.29%; P<0.05) 
      were observed in IE patients compared to controls. Expression levels of MCP1 
      (R=0.867) and CCR2 (R=0.835) in IE patients with HS were correlated with the 
      disease duration. However, no correlation was found in IE patients without HS. 
      There was also no correlation between levels of MCP1 and CCR2 in IE patients with 
      age, either with HS or without HS. These results suggest that MCP1 and its 
      receptor may play a role in the pathogenesis and progression of IE.
CI  - Copyright (c) 2015 Elsevier Ltd. All rights reserved.
FAU - Wang, Chunyan
AU  - Wang C
AD  - Department of Neurology, The First Affiliated Hospital of Harbin Medical 
      University, No. 23, Youzheng Street, Nangang District, Harbin 150001, 
      Heilongjiang, China.
FAU - Yang, Lihua
AU  - Yang L
AD  - Department of Neurology, The People's Hospital of Cangzhou, Cangzhou, China.
FAU - Zhang, Jiadong
AU  - Zhang J
AD  - Department of Neurology, The First Hospital of Harbin, Harbin, China.
FAU - Lin, Zhiguo
AU  - Lin Z
AD  - Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical 
      University, Harbin, China.
FAU - Qi, Jiping
AU  - Qi J
AD  - Department of Pathology, The First Hospital Affiliated of Harbin Medical 
      University, Harbin, China.
FAU - Duan, Shurong
AU  - Duan S
AD  - Department of Neurology, The First Affiliated Hospital of Harbin Medical 
      University, No. 23, Youzheng Street, Nangang District, Harbin 150001, 
      Heilongjiang, China. Electronic address: shurongduan0928@163.com.
LA  - eng
PT  - Journal Article
DEP - 20160122
PL  - Scotland
TA  - J Clin Neurosci
JT  - Journal of clinical neuroscience : official journal of the Neurosurgical Society 
      of Australasia
JID - 9433352
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Brain/*metabolism
MH  - Case-Control Studies
MH  - Chemokine CCL2/genetics/*metabolism
MH  - Drug Resistant Epilepsy/*metabolism
MH  - Female
MH  - Humans
MH  - Male
OTO - NOTNLM
OT  - CCR2
OT  - Human
OT  - Immunohistochemistry
OT  - Intractable epilepsy
OT  - MCP1
EDAT- 2016/01/27 06:00
MHDA- 2017/03/24 06:00
CRDT- 2016/01/27 06:00
PHST- 2015/03/03 00:00 [received]
PHST- 2015/06/23 00:00 [revised]
PHST- 2015/07/24 00:00 [accepted]
PHST- 2016/01/27 06:00 [entrez]
PHST- 2016/01/27 06:00 [pubmed]
PHST- 2017/03/24 06:00 [medline]
AID - S0967-5868(15)00649-9 [pii]
AID - 10.1016/j.jocn.2015.07.033 [doi]
PST - ppublish
SO  - J Clin Neurosci. 2016 Jun;28:134-40. doi: 10.1016/j.jocn.2015.07.033. Epub 2016 
      Jan 22.