PMID- 26812178
OWN - NLM
STAT- MEDLINE
DCOM- 20161226
LR  - 20161230
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 77
IP  - 4
DP  - 2016 Apr
TI  - sHLA-G1 and HLA-G5 levels are decreased in Tunisian women with multiple abortion.
PG  - 342-5
LID - S0198-8859(16)00028-8 [pii]
LID - 10.1016/j.humimm.2016.01.019 [doi]
AB  - Pregnancy is associated with increased levels of soluble (s) human leukocyte 
      antigen (HLA)-G molecules, while during abortion these molecules are decreased. 
      To date, little is known about the role of sHLA-G isoforms during abortion. In 
      this study, we investigated the levels of total sHLA-G and its isoforms: HLA-G1 
      (membrane shedded isoform) and alternative spliced HLA-G5 in plasma samples 
      obtained from 55 women who had experienced spontaneous abortion, 108 pregnant 
      healthy women and 56 non pregnant healthy women. We found that pregnant women 
      exhibited higher amounts of sHLA-G compared to either non pregnant women or women 
      with abortion. Among women who had experienced spontaneous abortion, women with 
      recurrent abortions (RSA) had lower sHLA-G than women with only one abortion. In 
      particular, RSA women were characterized by the absence of sHLA-G1 isoform, 
      suggesting a possible implication in abortion event.
CI  - Copyright (c) 2016 American Society for Histocompatibility and Immunogenetics. 
      Published by Elsevier Inc. All rights reserved.
FAU - Zidi, Ines
AU  - Zidi I
AD  - Laboratory Microorganismes et Biomolecules Actives, Sciences Faculty of Tunis, 
      University of Tunis El Manar, Tunis, Tunisia. Electronic address: 
      ines.zidi@techemail.com.
FAU - Rizzo, Roberta
AU  - Rizzo R
AD  - Department of Medical Sciences, Section Microbiology, University of Ferrara, 
      Ferrara, Italy.
FAU - Bouaziz, Aicha
AU  - Bouaziz A
AD  - Ecole superieure des Sciences et Techniques de la Sante de Sousse, Tunisia.
FAU - Laaribi, Ahmed Baligh
AU  - Laaribi AB
AD  - Laboratory Microorganismes et Biomolecules Actives, Sciences Faculty of Tunis, 
      University of Tunis El Manar, Tunis, Tunisia; Laboratory of 
      Microbiology-Immunology, CHU Farhat Hached, Sousse, Tunisia.
FAU - Zidi, Nour
AU  - Zidi N
AD  - Faculty of Medicine Ibn Al Jazzar, Sousse, Tunisia.
FAU - Di Luca, Dario
AU  - Di Luca D
AD  - Department of Medical Sciences, Section Microbiology, University of Ferrara, 
      Ferrara, Italy.
FAU - Tlili, Henda
AU  - Tlili H
AD  - Groupement de Sante de base, Sousse, Tunisia.
FAU - Bortolotti, Daria
AU  - Bortolotti D
AD  - Department of Medical Sciences, Section Microbiology, University of Ferrara, 
      Ferrara, Italy.
LA  - eng
PT  - Journal Article
DEP - 20160123
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Biomarkers)
RN  - 0 (HLA-G Antigens)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Abortion, Habitual/blood/*genetics/immunology
MH  - Adult
MH  - *Alleles
MH  - Biomarkers
MH  - Case-Control Studies
MH  - Female
MH  - Gene Expression
MH  - HLA-G Antigens/blood/*genetics/immunology
MH  - Humans
MH  - Middle Aged
MH  - Pregnancy
MH  - RNA, Messenger/genetics
MH  - Tunisia
MH  - Young Adult
OTO - NOTNLM
OT  - Abortion
OT  - HLA-G5
OT  - Pregnancy
OT  - sHLA-G
OT  - sHLA-G1
EDAT- 2016/01/27 06:00
MHDA- 2016/12/27 06:00
CRDT- 2016/01/27 06:00
PHST- 2015/07/30 00:00 [received]
PHST- 2015/11/20 00:00 [revised]
PHST- 2016/01/22 00:00 [accepted]
PHST- 2016/01/27 06:00 [entrez]
PHST- 2016/01/27 06:00 [pubmed]
PHST- 2016/12/27 06:00 [medline]
AID - S0198-8859(16)00028-8 [pii]
AID - 10.1016/j.humimm.2016.01.019 [doi]
PST - ppublish
SO  - Hum Immunol. 2016 Apr;77(4):342-5. doi: 10.1016/j.humimm.2016.01.019. Epub 2016 
      Jan 23.