PMID- 26812512
OWN - NLM
STAT- MEDLINE
DCOM- 20160909
LR  - 20240317
IS  - 1760-4788 (Electronic)
IS  - 1279-7707 (Linking)
VI  - 20
IP  - 2
DP  - 2016 Feb
TI  - Fish Oil Supplementation Increases Event-Related Posterior Cingulate Activation 
      in Older Adults with Subjective Memory Impairment.
PG  - 161-9
LID - 10.1007/s12603-015-0609-6 [doi]
AB  - OBJECTIVES: To determine the effects of long-chain omega-3 (LCn-3) fatty acids 
      found in fish oil, including eicosapentaenoic acid (EPA) and docosahexaenoic acid 
      (DHA), on cortical blood oxygen level-dependent (BOLD) activity during a working 
      memory task in older adults with subjective memory impairment. DESIGN: 
      Randomized, double-blind, placebo-controlled study. SETTING: Academic medical 
      center. PARTICIPANTS: Healthy older adults (62-80 years) with subjective memory 
      impairment, but not meeting criteria for mild cognitive impairment or dementia. 
      INTERVENTION: Fish oil (EPA+DHA: 2.4 g/d, n=11) or placebo (corn oil, n=10) for 
      24 weeks. MEASUREMENTS: Cortical BOLD response patterns during performance of a 
      sequential letter n-back working memory task were determined at baseline and week 
      24 by functional magnetic resonance imaging (fMRI). RESULTS: At 24 weeks 
      erythrocyte membrane EPA+DHA composition increased significantly from baseline in 
      participants receiving fish oil (+31%, p </= 0.0001) but not placebo (-17%, 
      p=0.06). Multivariate modeling of fMRI data identified a significant interaction 
      among treatment, visit, and memory loading in the right cingulate (BA 23/24), and 
      in the right sensorimotor area (BA 3/4). In the fish oil group, BOLD increases at 
      24 weeks were observed in the right posterior cingulate and left superior frontal 
      regions during memory loading. A region-of-interest analysis indicated that the 
      baseline to endpoint change in posterior cingulate cortex BOLD activity signal 
      was significantly greater in the fish oil group compared with the placebo group 
      during the 1-back (p=0.0003) and 2-back (p=0.0005) conditions. Among all 
      participants, the change in erythrocyte EPA+DHA during the intervention was 
      associated with performance in the 2-back working memory task (p = 0.01), and 
      with cingulate BOLD signal during the 1-back (p = 0.005) with a trend during the 
      2-back (p = 0.09). Further, cingulate BOLD activity was related to performance in 
      the 2-back condition. CONCLUSION: Dietary fish oil supplementation increases red 
      blood cell omega-3 content, working memory performance, and BOLD signal in the 
      posterior cingulate cortex during greater working memory load in older adults 
      with subjective memory impairment suggesting enhanced neuronal response to 
      working memory challenge.
FAU - Boespflug, E L
AU  - Boespflug EL
AD  - Robert Krikorian, PhD, Department of Psychiatry and Behavioral Neuroscience, 
      University of Cincinnati Academic Health Center, PO Box 670559, Cincinnati, OH 
      45267-0559, PH: 513-558-2455, FX: 513-558-0877, EM: robert.krikorian@uc.edu.
FAU - McNamara, R K
AU  - McNamara RK
FAU - Eliassen, J C
AU  - Eliassen JC
FAU - Schidler, M D
AU  - Schidler MD
FAU - Krikorian, R
AU  - Krikorian R
LA  - eng
SI  - ClinicalTrials.gov/NCT01746303
GR  - AG034617-01S2/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - France
TA  - J Nutr Health Aging
JT  - The journal of nutrition, health & aging
JID - 100893366
RN  - 0 (Fish Oils)
RN  - 25167-62-8 (Docosahexaenoic Acids)
RN  - AAN7QOV9EA (Eicosapentaenoic Acid)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Aged
MH  - Animals
MH  - *Dietary Supplements
MH  - Docosahexaenoic Acids/metabolism/pharmacology/*therapeutic use
MH  - Double-Blind Method
MH  - Eicosapentaenoic Acid/metabolism/pharmacology/*therapeutic use
MH  - Erythrocyte Membrane/drug effects/metabolism
MH  - Erythrocytes/drug effects/metabolism
MH  - Female
MH  - Fish Oils/metabolism/pharmacology/*therapeutic use
MH  - Gyrus Cinguli/*drug effects
MH  - Humans
MH  - Male
MH  - Memory Disorders/blood/*drug therapy
MH  - Memory, Short-Term/*drug effects
MH  - Middle Aged
MH  - Oxygen/blood
EDAT- 2016/01/27 06:00
MHDA- 2016/09/10 06:00
CRDT- 2016/01/27 06:00
PHST- 2016/01/27 06:00 [entrez]
PHST- 2016/01/27 06:00 [pubmed]
PHST- 2016/09/10 06:00 [medline]
AID - S1279-7707(23)01349-0 [pii]
AID - 10.1007/s12603-015-0609-6 [doi]
PST - ppublish
SO  - J Nutr Health Aging. 2016 Feb;20(2):161-9. doi: 10.1007/s12603-015-0609-6.