PMID- 26813368
OWN - NLM
STAT- MEDLINE
DCOM- 20160426
LR  - 20221207
IS  - 0376-2491 (Print)
IS  - 0376-2491 (Linking)
VI  - 95
IP  - 44
DP  - 2015 Nov 24
TI  - [Effect of CPAP therapy on dynamic glucose level in OSAHS patients with newly 
      diagnosed T2DM].
PG  - 3579-83
AB  - OBJECTIVE: To investigate the characteristic of dynamic glucose level in 
      obstructive sleep apnea-hypopnea syndrome (OSAHS) patients with newly diagnosed 
      type 2 diabetes mellitus (T2DM) and to evaluate the effect of continuous positive 
      airway pressure (CPAP) treatment on the glucose level. METHODS: A total of 65 
      cases of patients with T2DM who were newly diagnosed by oral glucose tolerance 
      test (OGTT) were enrolled from April 2014 to April 2015 in Gansu Provincial 
      Hospital, and divided into simple T2DM group (n=30) and OSAHS with T2DM group 
      (n=35) according to aponea-hypopnea index (AHI) which was monitored by 
      polysomnography (PSG). Their general clinical data were collected, and glucose 
      level of different periods was monitored by continuous glucose moitoring system 
      (CGMS). Changes of glucose level were compared between two groups before and 
      after CPAP treatment. RESULTS: Age, gender proportion, BMI, smoking and drinking 
      history, glycosylated hemoglobin (HbA1c) and blood lipid profile had no 
      significantly difference between two groups. Longer neck circumstance and higher 
      waist-hip ration (WHR), higher systolic blood pressure and diastolic blood 
      pressure, higher fasting plasma glucose (FPG) [(9.4 +/- 3.2) vs (7.3 +/- 2.1) mmol/L, 
      P=0.028] and fasting insulin (FINS) [(19.2 +/- 8.7) vs (11.1 +/- 4.7) mU/L, P=0.044] 
      level, more serious homeostasis model assessment insulin resistance (HOMA-IR) 
      were found in OSAHS patients with T2DM when compared to patients in simple T2DM 
      group. The average dynamic glucose level of 24 hours, daytime, nocturnal and 
      sleep time in OSAHS with T2DM group were higher than that in the simple T2DM 
      group (all P<0.05). The alarming times when the average dynamic glucose level of 
      nocturnal time was more than 0.1 mmol.L(-)(1).min(-)(1) in T2DM with OSAHS was more than 
      that in control group (P=0.001). After treatment of CPAP, the level of AHI [(5.9 
      +/- 3.6) vs (56.7 +/- 11.4) times/h, P<0.001], average dynamic glucose level of 24 
      hours, day, nocturnal and sleep time were obviously decreased (all P<0.05); 
      lowest saturation oxygen (LSpO(2)) was significantly increased [(92.3 +/- 3.7)% vs 
      (81.5 +/- 20.2)%, P<0.001]; the alarming times and HOMA-IR were obviously decreased 
      (P=0.019, 0.043). According to multiple linear regression analysis, the AHI 
      (beta=0.736, P<0.001) in OSAHS with T2DM group was positively related to the average 
      dynamic glucose level during sleep time, but the LSpO(2)(beta=-0.889, P<0.001) was 
      negatively correlated. CONCLUSIONS: OSAHS patients with newly diagnosed T2DM have 
      higher glucose level than that in simple T2DM patients, and CPAP therapy can 
      obviously decrease the glucose level in newly diagnosed T2DM patients with OSAHS. 
      AHI and LSpO(2)may influence the average dynamic glucose level during sleep time.
FAU - Zhao, Lijun
AU  - Zhao L
AD  - Sleep Medicine Center of Gansu Province, Gansu Provincial Hospital, Lanzhou 
      730000, China.
FAU - Hui, Peilin
AU  - Hui P
AD  - Sleep Medicine Center of Gansu Province, Gansu Provincial Hospital, Lanzhou 
      730000, China.
FAU - Xie, Yuping
AU  - Xie Y
AD  - Sleep Medicine Center of Gansu Province, Gansu Provincial Hospital, Lanzhou 
      730000, China; Email: xyp5894@163.com.
FAU - Hou, Yiping
AU  - Hou Y
AD  - Sleep Medicine Center of Gansu Province, Gansu Provincial Hospital, Lanzhou 
      730000, China.
FAU - Wei, Xiaoquan
AU  - Wei X
AD  - Sleep Medicine Center of Gansu Province, Gansu Provincial Hospital, Lanzhou 
      730000, China.
FAU - Ma, Wei
AU  - Ma W
AD  - Sleep Medicine Center of Gansu Province, Gansu Provincial Hospital, Lanzhou 
      730000, China.
FAU - Wang, Jinfeng
AU  - Wang J
AD  - Sleep Medicine Center of Gansu Province, Gansu Provincial Hospital, Lanzhou 
      730000, China.
FAU - Zhou, Liya
AU  - Zhou L
AD  - Sleep Medicine Center of Gansu Province, Gansu Provincial Hospital, Lanzhou 
      730000, China.
FAU - Zhang, Wenjuan
AU  - Zhang W
AD  - Sleep Medicine Center of Gansu Province, Gansu Provincial Hospital, Lanzhou 
      730000, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Yi Xue Za Zhi
JT  - Zhonghua yi xue za zhi
JID - 7511141
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Insulin)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Blood Pressure
MH  - *Continuous Positive Airway Pressure
MH  - *Diabetes Mellitus, Type 2
MH  - Glucose
MH  - Glucose Tolerance Test
MH  - Glycated Hemoglobin
MH  - Humans
MH  - Insulin
MH  - Insulin Resistance
MH  - Polysomnography
MH  - Sleep
MH  - Sleep Apnea, Obstructive
EDAT- 2016/01/28 06:00
MHDA- 2016/04/27 06:00
CRDT- 2016/01/28 06:00
PHST- 2016/01/28 06:00 [entrez]
PHST- 2016/01/28 06:00 [pubmed]
PHST- 2016/04/27 06:00 [medline]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi. 2015 Nov 24;95(44):3579-83.