PMID- 26814872
OWN - NLM
STAT- MEDLINE
DCOM- 20180509
LR  - 20221207
IS  - 0254-6450 (Print)
IS  - 0254-6450 (Linking)
VI  - 36
IP  - 9
DP  - 2015 Sep
TI  - [Meta-analysis of association between organophosphorus pesticides and aplastic 
      anemia].
PG  - 1005-9
AB  - OBJECTIVE: To evaluate the association between organophosphorus pesticides and 
      aplastic anemia, and provide scientific evidence for the primary prevention of 
      aplastic anemia. METHODS: The published papers of case control studies on the 
      association between organophosphorus pesticides and aplastic anemia from January 
      1990 to August 2014 were collected from Chinese BioMedical Literature Base (CBM), 
      Chinese National Knowledge Infrastructure (CNKI), PubMed and EMBASE. The papers 
      which met the inclusion criteria were evaluated. The pooled odds ratios (OR) and 
      95% confidence interval (CI) of organophosphorus pesticides were calculated with 
      software Review Manager 5.0. Subgroup analysis were conducted for different 
      population and different usage of organophosphorus pesticides. RESULTS: A total 
      of 9 papers were selected, involving 5 833 subjects (1 404 cases and 4 429 
      controls). The results showed that organophosphorus pesticides could increase the 
      risk of aplastic anemia (OR=1.97, 95% CI: 1.60-2.44) . Subgroup analysis showed 
      that Asian (OR=2.01, 95% CI: 1.52-2.66) had higher risk of aplastic anemia than 
      American or European (OR=1.93, 95% CI: 1.39-2.67) . Using pure organophosphorus 
      pesticides (OR=2.15, 95% CI: 1.60-2.88) was more prone to cause aplastic anemia 
      than using the mixture of organophosphorus pesticides (OR=1.82, 95% CI: 
      1.34-2.47). CONCLUSION: The analysis indicated that organophosphorus pesticides 
      might be a risk factor for aplastic anemia. Reducing organophosphorus pesticides 
      exposure in daily life and industrial or agricultural production could prevent 
      the incidence of aplastic anemia.
FAU - Zhang, Ji
AU  - Zhang J
AD  - Department of Epidemiology and Health Statistics, School of Public Health, 
      Central South University, Changsha 410078, China.
FAU - Yang, Tubao
AU  - Yang T
AD  - Department of Epidemiology and Health Statistics, School of Public Health, 
      Central South University, Changsha 410078, China; Email: 1064960669@qq.com.
LA  - chi
PT  - Journal Article
PT  - Meta-Analysis
PL  - China
TA  - Zhonghua Liu Xing Bing Xue Za Zhi
JT  - Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi
JID - 8208604
RN  - 0 (Organophosphorus Compounds)
RN  - 0 (Pesticides)
SB  - IM
MH  - Anemia, Aplastic/*chemically induced/*epidemiology
MH  - Asian People/*statistics & numerical data
MH  - Case-Control Studies
MH  - *Environmental Exposure
MH  - Humans
MH  - Incidence
MH  - Odds Ratio
MH  - Organophosphorus Compounds/*adverse effects
MH  - Pesticides/*adverse effects
MH  - Risk Factors
MH  - White People/statistics & numerical data
EDAT- 2016/01/28 06:00
MHDA- 2016/01/28 06:01
CRDT- 2016/01/28 06:00
PHST- 2016/01/28 06:00 [entrez]
PHST- 2016/01/28 06:00 [pubmed]
PHST- 2016/01/28 06:01 [medline]
PST - ppublish
SO  - Zhonghua Liu Xing Bing Xue Za Zhi. 2015 Sep;36(9):1005-9.