PMID- 26815570
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160129
LR  - 20181113
IS  - 1863-9933 (Print)
IS  - 1863-9933 (Linking)
VI  - 36
IP  - 1
DP  - 2010 Feb
TI  - Bone Fracture Healing with Umbilico-Placental Mononuclear Cells: A Controlled 
      Animal Study.
PG  - 60-6
LID - 10.1007/s00068-009-9038-8 [doi]
AB  - BACKGROUND: Fracture healing is a significant process in orthopedics. In this 
      controlled animal study, our aimis to expose the healing effects of cord blood 
      umbilico-placental mononuclear cells (UPMNCs) on bone fractures. MATERIALS AND 
      METHODS: Caesarean sections were performed on five pregnant New Zealand rabbits 
      at term. Placentas and cords were collected. Standard closed transverse shaft 
      fractures were created on both tibial bones of 15 baby rabbits. The right tibias 
      were given UPMNCs; the left tibias were the control group. Histological 
      examinations, osteoblast and osteoclast cell counts, and mechanical stabilities 
      were compared. Anchorage of the donor cells was shown by the fluorescence in situ 
      hybridization (FISH) technique. RESULTS: In the group injected with UPMNCs, 
      histopathological fracture healing was faster, osteoblast and osteoclast counts 
      were significantly increased, and the maximum load capacity was higher. The 
      presence of XX and XY chromatins on the same slide revealed the anchorage of 
      female donor cells on male tissues. CONCLUSION: The effects of umbilico-placental 
      mononuclear cells on bone healing are histopathological healing priority, 
      increased osteoblastic and osteoclastic activities (bone turnover), and better 
      mechanical stability.
FAU - Polat, Onur
AU  - Polat O
AD  - Ibni Sina Hospital Emergency Department, Ankara University, Faculty of Medicine 
      Ankara, Sihhiye, Turkey. onurpolat1971@yahoo.com.
AD  - Ibni Sina Hospital Emergency, Department Ankara, University Faculty of Medicine 
      Ankara, 06106, Sihhiye, Turkey. onurpolat1971@yahoo.com.
FAU - Polat, Gurur
AU  - Polat G
AD  - Ibni Sina Hospital Emergency Department, Ankara University, Faculty of Medicine 
      Ankara, Sihhiye, Turkey.
FAU - Karahuseyinoglu, Sercin
AU  - Karahuseyinoglu S
AD  - Ibni Sina Hospital Emergency Department, Ankara University, Faculty of Medicine 
      Ankara, Sihhiye, Turkey.
FAU - Kutlay, Nuket Yorur
AU  - Kutlay NY
AD  - Ibni Sina Hospital Emergency Department, Ankara University, Faculty of Medicine 
      Ankara, Sihhiye, Turkey.
FAU - Tasci, Arzu Gul
AU  - Tasci AG
AD  - Ibni Sina Hospital Emergency Department, Ankara University, Faculty of Medicine 
      Ankara, Sihhiye, Turkey.
FAU - Erdemli, Esra
AU  - Erdemli E
AD  - Ibni Sina Hospital Emergency Department, Ankara University, Faculty of Medicine 
      Ankara, Sihhiye, Turkey.
FAU - Tukun, Ajlan
AU  - Tukun A
AD  - Ibni Sina Hospital Emergency Department, Ankara University, Faculty of Medicine 
      Ankara, Sihhiye, Turkey.
FAU - Avunduk, Mustafa Cihat
AU  - Avunduk MC
AD  - Ibni Sina Hospital Emergency Department, Ankara University, Faculty of Medicine 
      Ankara, Sihhiye, Turkey.
FAU - Kuplulu, Sukru
AU  - Kuplulu S
AD  - Ibni Sina Hospital Emergency Department, Ankara University, Faculty of Medicine 
      Ankara, Sihhiye, Turkey.
FAU - Demirtas, Mehmet
AU  - Demirtas M
AD  - Ibni Sina Hospital Emergency Department, Ankara University, Faculty of Medicine 
      Ankara, Sihhiye, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20090911
PL  - Germany
TA  - Eur J Trauma Emerg Surg
JT  - European journal of trauma and emergency surgery : official publication of the 
      European Trauma Society
JID - 101313350
OTO - NOTNLM
OT  - Bone fracture
OT  - Cord blood
OT  - Mononuclear
OT  - Placenta
OT  - Stem cell
EDAT- 2010/02/01 00:00
MHDA- 2010/02/01 00:01
CRDT- 2016/01/28 06:00
PHST- 2009/02/15 00:00 [received]
PHST- 2009/07/20 00:00 [accepted]
PHST- 2016/01/28 06:00 [entrez]
PHST- 2010/02/01 00:00 [pubmed]
PHST- 2010/02/01 00:01 [medline]
AID - 10.1007/s00068-009-9038-8 [pii]
AID - 10.1007/s00068-009-9038-8 [doi]
PST - ppublish
SO  - Eur J Trauma Emerg Surg. 2010 Feb;36(1):60-6. doi: 10.1007/s00068-009-9038-8. 
      Epub 2009 Sep 11.