PMID- 26815786
OWN - NLM
STAT- MEDLINE
DCOM- 20180112
LR  - 20181113
IS  - 1573-7365 (Electronic)
IS  - 0885-7490 (Print)
IS  - 0885-7490 (Linking)
VI  - 31
IP  - 3
DP  - 2016 Jun
TI  - Alterations in white matter volume and integrity in obesity and type 2 diabetes.
PG  - 621-9
LID - 10.1007/s11011-016-9792-3 [doi]
AB  - Type 2 diabetes mellitus (T2DM) is characterized by obesity, hyperglycemia and 
      insulin resistance. Both T2DM and obesity are associated with cerebral 
      complications, including an increased risk of cognitive impairment and dementia, 
      however the underlying mechanisms are largely unknown. In the current study, we 
      aimed to determine the relative contributions of obesity and the presence of T2DM 
      to altered white matter structure. We used diffusion tensor imaging (DTI) and 
      voxel-based morphometry (VBM) to measure white matter integrity and volume in 
      obese T2DM patients without micro- or macrovascular complications, age- gender- 
      and BMI-matched normoglycemic obese subjects and age- and gender-matched 
      normoglycemic lean subjects. We found that obese T2DM patients compared with lean 
      subjects had lower axial diffusivity (in the right corticospinal tract, right 
      inferior fronto-occipital tract, right superior longitudinal fasciculus and right 
      forceps major) and reduced white matter volume (in the right inferior parietal 
      lobe and the left external capsule region). In normoglycemic obese compared with 
      lean subjects axial diffusivity as well as white matter volume tended to be 
      reduced, whereas there were no significant differences between normoglycemic 
      obese subjects and T2DM patients. Decreased white matter integrity and volume 
      were univariately related to higher age, being male, higher BMI, HbA1C and 
      fasting glucose and insulin levels. However, multivariate analyses demonstrated 
      that only BMI was independently related to white matter integrity, and age, 
      gender and BMI to white matter volume loss. Our data indicate that obese T2DM 
      patients have reduced white matter integrity and volume, but that this is largely 
      explained by BMI, rather than T2DM per se.
FAU - van Bloemendaal, Liselotte
AU  - van Bloemendaal L
AD  - Diabetes Center / Department of Internal Medicine, VU University Medical Center, 
      PO BOX 7057, 1007 MB, Amsterdam, The Netherlands. l.vanbloemendaal@vumc.nl.
FAU - Ijzerman, Richard G
AU  - Ijzerman RG
AD  - Diabetes Center / Department of Internal Medicine, VU University Medical Center, 
      PO BOX 7057, 1007 MB, Amsterdam, The Netherlands.
FAU - Ten Kulve, Jennifer S
AU  - Ten Kulve JS
AD  - Diabetes Center / Department of Internal Medicine, VU University Medical Center, 
      PO BOX 7057, 1007 MB, Amsterdam, The Netherlands.
FAU - Barkhof, Frederik
AU  - Barkhof F
AD  - Department of Radiology & Nuclear Medicine, VU University Medical Center, 1007 
      MB, Amsterdam, The Netherlands.
FAU - Diamant, Michaela
AU  - Diamant M
AD  - Diabetes Center / Department of Internal Medicine, VU University Medical Center, 
      PO BOX 7057, 1007 MB, Amsterdam, The Netherlands.
FAU - Veltman, Dick J
AU  - Veltman DJ
AD  - Department of Psychiatry, VU University Medical Center, 1007 MB, Amsterdam, The 
      Netherlands.
FAU - van Duinkerken, Eelco
AU  - van Duinkerken E
AD  - Diabetes Center / Department of Internal Medicine, VU University Medical Center, 
      PO BOX 7057, 1007 MB, Amsterdam, The Netherlands.
AD  - Department of Medical Psychology, VU University Medical Center, 1007 MB, 
      Amsterdam, The Netherlands.
AD  - Department of Psychology, Pontificia Universidade Catolica (PUC-Rio), Rio de 
      Janeiro, RJ, Brazil.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160127
PL  - United States
TA  - Metab Brain Dis
JT  - Metabolic brain disease
JID - 8610370
SB  - IM
MH  - Brain/*diagnostic imaging
MH  - Diabetes Mellitus, Type 2/*diagnostic imaging
MH  - Diffusion Tensor Imaging
MH  - Female
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Male
MH  - Middle Aged
MH  - Obesity/*diagnostic imaging
MH  - Organ Size
MH  - White Matter/*diagnostic imaging
PMC - PMC4863900
OTO - NOTNLM
OT  - Brain
OT  - DTI
OT  - Integrity
OT  - Obesity
OT  - Type 2 diabetes
OT  - VBM
OT  - Volume
OT  - White matter
EDAT- 2016/01/28 06:00
MHDA- 2018/01/13 06:00
PMCR- 2016/01/27
CRDT- 2016/01/28 06:00
PHST- 2015/08/27 00:00 [received]
PHST- 2016/01/08 00:00 [accepted]
PHST- 2016/01/28 06:00 [entrez]
PHST- 2016/01/28 06:00 [pubmed]
PHST- 2018/01/13 06:00 [medline]
PHST- 2016/01/27 00:00 [pmc-release]
AID - 10.1007/s11011-016-9792-3 [pii]
AID - 9792 [pii]
AID - 10.1007/s11011-016-9792-3 [doi]
PST - ppublish
SO  - Metab Brain Dis. 2016 Jun;31(3):621-9. doi: 10.1007/s11011-016-9792-3. Epub 2016 
      Jan 27.