PMID- 26817006
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160128
LR  - 20201001
IS  - 2287-1012 (Print)
IS  - 2287-1292 (Electronic)
IS  - 2287-1012 (Linking)
VI  - 20
IP  - 4
DP  - 2015 Dec
TI  - Value of serum 1,5-anhydroglucitol measurements in childhood obesity in the 
      continuum of diabetes.
PG  - 192-7
LID - 10.6065/apem.2015.20.4.192 [doi]
AB  - PURPOSE: The prevalence of type 2 diabetes mellitus (T2DM) and obesity are 
      currently increasing. Accordingly, the concept of "preventing diabetes" in 
      high-risk groups has become more important in diabetic care, but the use of 
      glycated hemoglobin (HbA1c) as a measure has limitations in this field. The aim 
      of this study was to investigate the utility of 1,5-anhydroglucitol (1,5-AG) in 
      assessing prediabetes status in obese children. METHODS: The medical records of 
      74 subjects aged 6-19 years (of which 27 were overweight/obese and 47 had 
      diabetes) who had 1,5-AG data were reviewed retrospectively. We compared 1,5-AG 
      with HbA1c using the Pearson correlation test to assess the clinical utility of 
      1,5-AG. RESULTS: 1,5-AG levels were higher (31.1+/-10.1 microg/mL vs. 7.4+/-7.3 microg/mL) 
      and HbA1c levels were lower (5.5%+/-0.3% vs. 8.9%+/-2.7%) in the overweight/obese 
      group than in the diabetics group. The range of 1,5-AG levels in obese children 
      was wide (16.8-59.3 microg/mL), and did not have significance with HbA1c. A negative 
      correlation between 1,5-AG and HbA1c was significant in the entire subject 
      (r=-0.822, P<0.001), and also in the HbA1c range of 5.5% to 8% (r=-0.736, 
      P<0.001). CONCLUSION: 1,5-AG is a valuable index in the HbA1c range of 5.5%-8% 
      and it might be considered an early glycemic control index in insulin-resistant 
      obese children with an HbA1c level above 5.5%. Moreover, the 1,5-AG level 
      assessment should be presented as a supplementary tool for better compliance, as 
      well as being an improvement in diabetes management for the short-term glucose 
      control in relatively well-controlled diabetes patients with an HbA1c level below 
      8%.
FAU - Yoo, Ha Yeong
AU  - Yoo HY
AD  - Department of Pediatrics, Konkuk University Medical Center, Konkuk University 
      School of Medicine, Seoul, Korea.
FAU - Kwak, Byung Ok
AU  - Kwak BO
AD  - Department of Pediatrics, Konkuk University Medical Center, Konkuk University 
      School of Medicine, Seoul, Korea.
FAU - Son, Jae Sung
AU  - Son JS
AD  - Department of Pediatrics, Konkuk University Medical Center, Konkuk University 
      School of Medicine, Seoul, Korea.
FAU - Kim, Kyo Sun
AU  - Kim KS
AD  - Department of Pediatrics, Konkuk University Medical Center, Konkuk University 
      School of Medicine, Seoul, Korea.
FAU - Chung, Sochung
AU  - Chung S
AD  - Department of Pediatrics, Konkuk University Medical Center, Konkuk University 
      School of Medicine, Seoul, Korea.
LA  - eng
PT  - Journal Article
DEP - 20151231
PL  - Korea (South)
TA  - Ann Pediatr Endocrinol Metab
JT  - Annals of pediatric endocrinology & metabolism
JID - 101588279
PMC - PMC4722158
OTO - NOTNLM
OT  - 1,5-anhydroglucitol
OT  - Diabetes mellitus
OT  - Obesity
OT  - Prediabetic state
COIS- Conflict of interest: No potential conflict of interest relevant to this article 
      was reported.
EDAT- 2016/01/28 06:00
MHDA- 2016/01/28 06:01
PMCR- 2015/12/01
CRDT- 2016/01/28 06:00
PHST- 2015/08/08 00:00 [received]
PHST- 2015/09/05 00:00 [revised]
PHST- 2015/11/19 00:00 [accepted]
PHST- 2016/01/28 06:00 [entrez]
PHST- 2016/01/28 06:00 [pubmed]
PHST- 2016/01/28 06:01 [medline]
PHST- 2015/12/01 00:00 [pmc-release]
AID - 10.6065/apem.2015.20.4.192 [doi]
PST - ppublish
SO  - Ann Pediatr Endocrinol Metab. 2015 Dec;20(4):192-7. doi: 
      10.6065/apem.2015.20.4.192. Epub 2015 Dec 31.