PMID- 26817099
OWN - NLM
STAT- MEDLINE
DCOM- 20160223
LR  - 20161126
IS  - 1682-8658 (Print)
IS  - 1682-8658 (Linking)
IP  - 6
DP  - 2015
TI  - [HIGH FREQUENCY OF CYP2C19 ULTRARAPID METABOLIZERS IN RUSSIAN PATIENTS WITH 
      PEPTIC ULCER].
PG  - 11-5
AB  - INTRODUCTION: The main enzyme responsible for metabolism of proton pump 
      inhibitors (PPI) is cytochrome P-4502C19 (CYP2C19). Among all CYP2C19 
      polymorphisms ulrarapid CYP2C19*17 allele plays an important role in clinical 
      practice as in CYP2C19*17 allele carriers acid suppression achieved with PPI 
      including eradication regimens may be insufficient. THE AIM OF THE STUDY: To find 
      the frequency of CYP2C19 ultrarapid metabolizers in Russian patients with peptic 
      ulcer METHODS: We retrospectively reviewed the results of pharmacogenetic tests 
      of 971 Russian patients with endoscopically and histologically proven ulcers, 428 
      male (44%) and 543 female (56%). The mean age was 44.6 +/- 11.9 years (range 15-88 
      years). DNA was extracted from EDTA whole blood samples (10 mL). The 
      polymorphisms CYP2C19 *2, *3 *17 were evaluated using real-time polymerase chain 
      reaction (RT-PCR). RESULTS: We found that among 971 peptic ulcer patients 
      ultrarapid metabolizers (CYP2C19*1/*17, CYP2C19*17/*17) were the most frequent 
      genotype--39.75%. Extensive metabolizers with CYP2C19*1/*1 genotype were less 
      frequent--32.65%. Frequency of poor and intermediate metabolizers was found to be 
      1.5% and 25.85% respectively. We were the first to investigate CYP2C19*17 allele 
      frequency in Russian patients with peptic ulcer which was found to be 27.4%. 
      CONCLUSION: High frequency of CYP2C19 ultrarapid metabolizers in Russian patients 
      with peptic ulcer may be associated with insufficient response to proton pump 
      inhibitors.
FAU - Denisenko, N P
AU  - Denisenko NP
FAU - Sychev D A
AU  - Sychev D A
FAU - Sizova, Zh M
AU  - Sizova ZhM
FAU - Grachev, A V
AU  - Grachev AV
FAU - Velikolug, K A
AU  - Velikolug KA
LA  - rus
PT  - Journal Article
PL  - Russia (Federation)
TA  - Eksp Klin Gastroenterol
JT  - Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical 
      gastroenterology
JID - 101144944
RN  - 0 (Proton Pump Inhibitors)
RN  - EC 1.14.14.1 (CYP2C19 protein, human)
RN  - EC 1.14.14.1 (Cytochrome P-450 CYP2C19)
SB  - IM
MH  - Adult
MH  - *Cytochrome P-450 CYP2C19/genetics/metabolism
MH  - Female
MH  - *Gene Frequency
MH  - *Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Moscow
MH  - *Peptic Ulcer/drug therapy/enzymology/genetics
MH  - *Polymorphism, Genetic
MH  - *Proton Pump Inhibitors/administration & dosage/pharmacokinetics
MH  - Retrospective Studies
EDAT- 2016/01/29 06:00
MHDA- 2016/02/26 06:00
CRDT- 2016/01/29 06:00
PHST- 2016/01/29 06:00 [entrez]
PHST- 2016/01/29 06:00 [pubmed]
PHST- 2016/02/26 06:00 [medline]
PST - ppublish
SO  - Eksp Klin Gastroenterol. 2015;(6):11-5.