PMID- 26817225
OWN - NLM
STAT- MEDLINE
DCOM- 20160211
LR  - 20181202
IS  - 0125-2208 (Print)
IS  - 0125-2208 (Linking)
VI  - 98 Suppl 9
DP  - 2015 Oct
TI  - Effect of Inhaling Bergamot Oil on Depression-Related Behaviors in Chronic 
      Stressed Rats.
PG  - S152-9
AB  - BACKGROUND: Bergamot essential oil (BEO) possesses sedation and anxiolytic 
      properties similar to diazepam. After long period of exposure to stressors, 
      including restrained stress, depressive-like behavior can be produced. BEO has 
      been suggested to reduce depression. However, there is no scientific evidence 
      supporting this property. OBJECTIVE: To investigate the effect of BEO in chronic 
      stressed rats on: 1) behavior related depressive disorder, 2) hypothalamic 
      pituitary adrenal (HPA) axis response, and iii) brain-derived neurotrophic factor 
      (BDNF) protein levels in hippocampus. MATERIAL AND METHOD: Male Wistar rats, 
      weighing 200 to 250 g, were induced chronic restrained stress 15 minutes dailyfor 
      two weeks. For the next two weeks, these rats were divided intofour groups, 
      control-i.p., fluoxetine-i.p., control-inhale, and BEO-inhale. Fluoxetine (10 
      mg/kg i.p.) or saline was intraperitoneally administered daily while 2.5% BEO or 
      saline was inhaled daily. At the end of the treatment, rats were assessed for 
      depressive-like behavior using the forced swimming test (FST). After the 
      behavioral test, the animals were immediately decapitated and trunk blood samples 
      were collected for the measurement ofcorticosterone and adrenocorticotropic 
      hormone (ACTH) levels and hippocampus was dissected and stored in afreezer at -80 
       degrees C until assay for BDNF protein. RESULTS: BEO andfluoxetine significantly 
      decreased the immobility time in the FST (p < 0.05). Fluoxetine tended to 
      decrease serum corticosterone and significantly (p < 0.05) decreased serum ACTH 
      while BEO had no effect on these two stress hormones. For BDNF protein 
      determination, neither BEO norfluoxetine had any effect on BDNF protein levels in 
      hippocampus compared to their controls. CONCLUSION: The inhalation ofBEO decrease 
      behavior related depressive disorder similar tofluoxetine but has no effect on 
      HPA axis response and BDNF protein levels in chronic restrained stress.
FAU - Saiyudthong, Somrudee
AU  - Saiyudthong S
FAU - Mekseepralard, Chantana
AU  - Mekseepralard C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Thailand
TA  - J Med Assoc Thai
JT  - Journal of the Medical Association of Thailand = Chotmaihet thangphaet
JID - 7507216
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Oils, Volatile)
RN  - 0 (Plant Oils)
RN  - 39W1PKE3JI (bergamot oil)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Corticosterone/blood
MH  - Depression/*drug therapy
MH  - Depressive Disorder/drug therapy
MH  - Hippocampus/metabolism
MH  - Hypothalamo-Hypophyseal System/drug effects
MH  - Male
MH  - Oils, Volatile/pharmacology
MH  - Pituitary-Adrenal System/drug effects
MH  - Plant Oils/administration & dosage/*pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Stress, Psychological/*drug therapy
EDAT- 2016/01/29 06:00
MHDA- 2016/02/13 06:00
CRDT- 2016/01/29 06:00
PHST- 2016/01/29 06:00 [entrez]
PHST- 2016/01/29 06:00 [pubmed]
PHST- 2016/02/13 06:00 [medline]
PST - ppublish
SO  - J Med Assoc Thai. 2015 Oct;98 Suppl 9:S152-9.