PMID- 26817235
OWN - NLM
STAT- MEDLINE
DCOM- 20160223
LR  - 20181202
IS  - 0125-2208 (Print)
IS  - 0125-2208 (Linking)
VI  - 99 Suppl 1
DP  - 2016 Jan
TI  - Andrographolide Ameliorates Beta-Naphthoflavone-Induced CYP1A Enzyme Activity and 
      Lipid Peroxidation in Hamsters with Acute Opisthorchiasis.
PG  - S22-7
AB  - BACKGROUND: Opisthorchis viverrini (OV) infection generates oxidative stress/free 
      radicals and is considered as a primary cause ofcholangiocarcinoma since it 
      primarily triggers sclerosing cholangitis. OBJECTIVE: In this study, the impacts 
      of andrographolide on acute opisthorchaisis in beta-naphthoflavone (BNF)-exposed 
      hamsters were investigated. MATERIAL AND METHOD: Ethoxyresorufin O-deethylase 
      (EROD) and methoxyresorufin O-demethylase (MROD) activities and Thiobarbituric 
      acid reaction substances (TBARS) assay of andrographolide in acute 
      opisthorchiasis in the BNF-exposed hamsters were assessed. RESULTS: The results 
      showed that andrographolide ameliorated the hepatic CYP1A1 and CYP1A2 activities 
      by decreases of the specific enzymatic reactions of EROD and MROD, respectively, 
      in the BNF-exposed hamsters. Moreover, andrographolide lowered the formation of 
      malondialdehyde in the livers and brains of the hamsters. CONCLUSION: These 
      observations revealed the promising chemo-protective and antioxidant activities 
      of andrographolide via suppression of the specific EROD and MROD reactions and 
      lipid peroxidation against acute opisthorchiasis in the BNF-exposed hamsters.
FAU - Udomsuk, Latiporn
AU  - Udomsuk L
FAU - Chatuphonprasert, Waranya
AU  - Chatuphonprasert W
FAU - Jarukamjorn, Kanokwan
AU  - Jarukamjorn K
FAU - Sithithaworn, Paiboon
AU  - Sithithaworn P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Thailand
TA  - J Med Assoc Thai
JT  - Journal of the Medical Association of Thailand = Chotmaihet thangphaet
JID - 7507216
RN  - 0 (Anthelmintics)
RN  - 0 (Diterpenes)
RN  - 0 (Enzyme Activators)
RN  - 410105JHGR (andrographolide)
RN  - 6051-87-2 (beta-Naphthoflavone)
RN  - EC 1.14.14.1 (Cytochrome P-450 CYP1A1)
RN  - EC 1.14.14.1 (Cytochrome P-450 CYP1A2)
SB  - IM
MH  - Acute Disease
MH  - Animals
MH  - Anthelmintics/*pharmacology
MH  - Cytochrome P-450 CYP1A1/genetics/*metabolism
MH  - Cytochrome P-450 CYP1A2/genetics/*metabolism
MH  - Diterpenes/*pharmacology
MH  - Enzyme Activators/chemistry
MH  - Female
MH  - Lipid Peroxidation/*drug effects
MH  - *Mesocricetus
MH  - Opisthorchiasis/enzymology/metabolism/parasitology/*veterinary
MH  - Opisthorchis/physiology
MH  - Rodent Diseases/enzymology/*metabolism/parasitology
MH  - beta-Naphthoflavone/chemistry
EDAT- 2016/01/29 06:00
MHDA- 2016/02/26 06:00
CRDT- 2016/01/29 06:00
PHST- 2016/01/29 06:00 [entrez]
PHST- 2016/01/29 06:00 [pubmed]
PHST- 2016/02/26 06:00 [medline]
PST - ppublish
SO  - J Med Assoc Thai. 2016 Jan;99 Suppl 1:S22-7.