PMID- 26817310
OWN - NLM
STAT- MEDLINE
DCOM- 20160223
LR  - 20221207
IS  - 1009-3591 (Print)
IS  - 1009-3591 (Linking)
VI  - 21
IP  - 12
DP  - 2015 Dec
TI  - [Protamine gene polymorphisms and male infertility].
PG  - 1134-7
AB  - Protamine (PRM) is one of the most abundant arginine-rich nucleoproteins in sperm 
      and plays an important role in spermatogenesis. In the late stage of 
      spermatogenesis, the replacement of PRM by histone prompts the closer combination 
      between the nuclear matrix of sperm and nucleoprotein in order for high 
      enrichment and condensation of nuclear chromatin in addition to preventing the 
      sperm genome from mutation induced by internal and external factors. With the 
      development of DNA sequencing techniques, researches on the association between 
      PRM polymorphisms and male fertility are surfacing as a hot field. Many studies 
      show that rs2301365 polymorphism is a risk factor for male infertility and 
      increases the risk of male infertility by 27 - 66%, that rs737008 polymorphism of 
      PRM1 and rs1646022 polymorphism of PRM2 are protective factors against Asian 
      infertility, and that the ratio of PRM1 to PRM2 is intensively associated with 
      male infertility. This review presents an update on the association between PRM 
      gene polymorphisms and male infertility.
FAU - Jiang, Wei-jun
AU  - Jiang WJ
FAU - Zhang, Jing
AU  - Zhang J
FAU - Xia, Xin-yi
AU  - Xia XY
FAU - Xu, Hao-qin
AU  - Xu HQ
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Nan Ke Xue
JT  - Zhonghua nan ke xue = National journal of andrology
JID - 101093592
RN  - 0 (Protamines)
SB  - IM
MH  - Asian People
MH  - Humans
MH  - Infertility, Male/*genetics
MH  - Male
MH  - Mutation
MH  - *Polymorphism, Single Nucleotide
MH  - Protamines/*genetics
MH  - Risk Factors
MH  - Spermatogenesis
MH  - Spermatozoa
EDAT- 2016/01/29 06:00
MHDA- 2016/02/26 06:00
CRDT- 2016/01/29 06:00
PHST- 2016/01/29 06:00 [entrez]
PHST- 2016/01/29 06:00 [pubmed]
PHST- 2016/02/26 06:00 [medline]
PST - ppublish
SO  - Zhonghua Nan Ke Xue. 2015 Dec;21(12):1134-7.