PMID- 26817806
OWN - NLM
STAT- MEDLINE
DCOM- 20170515
LR  - 20200416
IS  - 1743-2928 (Electronic)
IS  - 1351-0002 (Print)
IS  - 1351-0002 (Linking)
VI  - 21
IP  - 5
DP  - 2016 Sep
TI  - Redox imbalance in peripheral blood of type 1 myotonic dystrophy patients.
PG  - 232-7
LID - 10.1080/13510002.2015.1107311 [doi]
AB  - OBJECTIVES: The aim of our study was to determine if redox imbalance caused by 
      the activities of antioxidant enzymes existed in erythrocytes of type 1 myotonic 
      dystrophy (DM1) patients. METHODS: The activities of erythrocyte superoxide 
      dismutase, catalase, glutathione peroxidase, and glutathione reductase were 
      measured in 30 DM1 patients and 15 healthy controls (HCs). The obtained values 
      were correlated with the Muscular Impairment Rating Scale (MIRS) score and 
      creatine kinase (CK). RESULTS: Superoxide dismutase and catalase activities were 
      lower in DM1 patients compared to HCs. A positive correlation was found between 
      disease duration and MIRS score as well as with glutathione reductase activity. 
      In DM1 patients, there were positive correlations between catalase, glutathione 
      peroxidase, and glutathione reductase activities. After sub-dividing DM1 patients 
      according to CK levels, superoxide dismutase activity was still statistically 
      different from HCs. However, catalase activity was significantly lower only in 
      DM1 patients with increased CK. DISCUSSION: Undesirable alterations in 
      antioxidant enzyme activities during DM1 disease progression may result in 
      conditions favoring oxidative stress and changes in metabolism which together 
      could contribute to muscle wasting.
FAU - Nikolic-Kokic, Aleksandra
AU  - Nikolic-Kokic A
AD  - a Department of Physiology, Institute for Biological Research Sinisa Stankovic , 
      University of Belgrade , Serbia.
FAU - Marinkovic, Dragan
AU  - Marinkovic D
AD  - b Faculty for Special Education and Rehabilitation , University of Belgrade , 
      Serbia.
FAU - Peric, Stojan
AU  - Peric S
AD  - c Neurology Clinic, Clinical Centre of Serbia, School of Medicine , University of 
      Belgrade , Serbia.
FAU - Stevic, Zorica
AU  - Stevic Z
AD  - c Neurology Clinic, Clinical Centre of Serbia, School of Medicine , University of 
      Belgrade , Serbia.
FAU - Spasic, Mihajlo B
AU  - Spasic MB
AD  - a Department of Physiology, Institute for Biological Research Sinisa Stankovic , 
      University of Belgrade , Serbia.
FAU - Blagojevic, Dusko
AU  - Blagojevic D
AD  - a Department of Physiology, Institute for Biological Research Sinisa Stankovic , 
      University of Belgrade , Serbia.
FAU - Rakoc evic-Stojanovic, Vidosava
AU  - Rakoc evic-Stojanovic V
AD  - c Neurology Clinic, Clinical Centre of Serbia, School of Medicine , University of 
      Belgrade , Serbia.
LA  - eng
PT  - Journal Article
DEP - 20160205
PL  - England
TA  - Redox Rep
JT  - Redox report : communications in free radical research
JID - 9511366
RN  - EC 1.11.1.6 (Catalase)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - EC 1.8.1.7 (Glutathione Reductase)
SB  - IM
MH  - Adult
MH  - Catalase/metabolism
MH  - Erythrocytes/metabolism
MH  - Female
MH  - Glutathione Peroxidase/metabolism
MH  - Glutathione Reductase/metabolism
MH  - Humans
MH  - Male
MH  - Myotonic Dystrophy/*metabolism/pathology
MH  - Oxidation-Reduction
MH  - Oxidative Stress/physiology
MH  - Superoxide Dismutase/metabolism
PMC - PMC6837567
OTO - NOTNLM
OT  - Catalase
OT  - Erythrocytes
OT  - Glutathione reductase
OT  - Glutatione peroxidase
OT  - Superoxide dismutase
OT  - Type 1 myotonic dystrophy
COIS- Conflict of interest The authors state that there are no conflicts of interest 
      regarding the publication of this article.
EDAT- 2016/01/29 06:00
MHDA- 2017/05/16 06:00
PMCR- 2016/02/05
CRDT- 2016/01/29 06:00
PHST- 2016/01/29 06:00 [entrez]
PHST- 2016/01/29 06:00 [pubmed]
PHST- 2017/05/16 06:00 [medline]
PHST- 2016/02/05 00:00 [pmc-release]
AID - 1107311 [pii]
AID - 10.1080/13510002.2015.1107311 [doi]
PST - ppublish
SO  - Redox Rep. 2016 Sep;21(5):232-7. doi: 10.1080/13510002.2015.1107311. Epub 2016 
      Feb 5.