PMID- 26817860
OWN - NLM
STAT- MEDLINE
DCOM- 20161230
LR  - 20221207
IS  - 1873-460X (Electronic)
IS  - 1056-8727 (Linking)
VI  - 30
IP  - 3
DP  - 2016 Apr
TI  - Non-linear associations of risk factors with mild hypoglycemia among Chinese 
      patients with type 2 diabetes.
PG  - 462-8
LID - S1056-8727(15)00513-9 [pii]
LID - 10.1016/j.jdiacomp.2015.12.024 [doi]
AB  - AIMS: The present study aimed to examine the nonlinear associations between risk 
      factors and mild hypoglycemia in Chinese patients with type 2 diabetes mellitus 
      (T2DM). METHODS: From May 2013 to August 2013, we conducted a cross sectional 
      survey of 6633 inpatients with T2DM and without severe hypoglycemia, aged 21-77 
      years, from 81 top tertiary hospitals in China. Mild hypoglycemia was defined as 
      having hypoglycemia with symptoms in one month. Binary logistic regression 
      analysis with restricted cubic splines was used to estimate odds ratio curves of 
      non-linear risk factors for mild hypoglycemia. RESULTS: Increasing body mass 
      index was associated with decreasing risk of mild hypoglycemia in a linear manner 
      while age, duration of diabetes, glycated hemoglobin (HbA1c), mean artery 
      pressure and lipids were associated with mild hypoglycemia in non-linear manners. 
      Age >/=40 years, duration >/=2 years, HbA1c >/=7.0-<11.5% (>/=53-<102 mmol/mol), 
      triglyceride >/=1.7-<3.6 mmol/L, low-density lipoprotein cholesterol (LDL-C) 
      >/=2.6-<4.8 mmol/L, and high-density lipoprotein cholesterol (HDL-C) >/=1.2-<4.8 
      mmol/L were associated with increased risks of mild hypoglycemia. CONCLUSIONS: 
      Chinese T2DM patients with age>/=40 years, duration of diabetes >/=2-<6 years, HbA1c 
      >/=7.0-<11.5% (>/=53-<102 mmol/mol), LDL-C >/=2.6-<4.8mmol/L, HDL-C >/=1.2-<4.8 mmol/L or 
      triglyceride >/=1.7-<3.6 mmol/L were at particularly high risk for mild 
      hypoglycemia.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Gu, Weijun
AU  - Gu W
AD  - Department of Endocrinology, Chinese PLA General Hospital, Beijing, China.
FAU - Ren, Yanfeng
AU  - Ren Y
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Tianjin 
      Medical University, Tianjin, China.
FAU - Ji, Linong
AU  - Ji L
AD  - Department of Endocrinology, Peking University People's Hospital, Beijing, China.
FAU - Hong, Tianpei
AU  - Hong T
AD  - Department of Endocrinology, Peking University Third Hospital, Beijing, China. 
      Electronic address: tpho66@bjmu.edu.cn.
FAU - Mu, Yiming
AU  - Mu Y
AD  - Department of Endocrinology, Chinese PLA General Hospital, Beijing, China.
FAU - Guo, Lixin
AU  - Guo L
AD  - Department of Endocrinology, Beijing Hospital, Beijing, China.
FAU - Li, Qiang
AU  - Li Q
AD  - Department of Endocrinology, The 2nd Affiliated Hospital of Harbin Medical 
      University, Harbin, Heilongjiang, China.
FAU - Tian, Qing
AU  - Tian Q
AD  - Department of Endocrinology, Peking University Third Hospital, Beijing, China.
FAU - Yang, Xilin
AU  - Yang X
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Tianjin 
      Medical University, Tianjin, China. Electronic address: yangxilin@tmu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151229
PL  - United States
TA  - J Diabetes Complications
JT  - Journal of diabetes and its complications
JID - 9204583
RN  - 0 (Glycated Hemoglobin A)
SB  - IM
MH  - Adult
MH  - Aged
MH  - China/epidemiology
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/blood/complications/*epidemiology
MH  - Female
MH  - Glycated Hemoglobin/analysis
MH  - Humans
MH  - Hypoglycemia/complications/*epidemiology
MH  - Male
MH  - Middle Aged
MH  - Nonlinear Dynamics
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - Young Adult
OTO - NOTNLM
OT  - Chinese
OT  - Mild hypoglycemia
OT  - Nonlinear association
OT  - Risk factors
OT  - Type 2 diabetes
EDAT- 2016/01/29 06:00
MHDA- 2016/12/31 06:00
CRDT- 2016/01/29 06:00
PHST- 2015/07/17 00:00 [received]
PHST- 2015/12/24 00:00 [revised]
PHST- 2015/12/25 00:00 [accepted]
PHST- 2016/01/29 06:00 [entrez]
PHST- 2016/01/29 06:00 [pubmed]
PHST- 2016/12/31 06:00 [medline]
AID - S1056-8727(15)00513-9 [pii]
AID - 10.1016/j.jdiacomp.2015.12.024 [doi]
PST - ppublish
SO  - J Diabetes Complications. 2016 Apr;30(3):462-8. doi: 
      10.1016/j.jdiacomp.2015.12.024. Epub 2015 Dec 29.