PMID- 26818892
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20181202
IS  - 1872-8227 (Electronic)
IS  - 0168-8227 (Linking)
VI  - 114
DP  - 2016 Apr
TI  - Gestational diabetes: Glycaemic predictors for fetal macrosomia and maternal risk 
      of future diabetes.
PG  - 99-105
LID - S0168-8227(16)00023-1 [pii]
LID - 10.1016/j.diabres.2015.12.017 [doi]
AB  - AIMS: To investigate how glucose levels at diagnosis of gestational diabetes 
      (GDM) are associated with infant birth weight and long-term risk of manifest 
      diabetes mellitus in the mother. METHODS: In a case control study GDM pregnancies 
      (n=2085) were compared with non-GDM pregnancies matched for day of delivery and 
      obstetric unit (n=3792). GDM was defined as capillary blood glucose (cB-glucose) 
      >/=9.0mmol/l (plasma glucose >/=10.0mmol/l) after a 75g oral glucose tolerance test 
      (OGTT). The GDM cohort were followed up 8.5-13.5yrs after initial diagnosis with 
      a questionnaire, answered by 1324 GDM women (65%). RESULTS: GDM women had higher 
      mean infant birth-weight compared with controls (3682g vs. 3541g, P<0.001). In 
      multiple linear regression analysis, birth weight was positively correlated to 
      fasting cB-glucose at GDM diagnosis (P<0.001), increased week of gestation 
      (P<0.001) and BMI before pregnancy (P<0.003), while 2h OGTT cB-glucose values 
      >/=9.0mmol/l were not related. Infants born to mothers with fasting cB-glucose 
      </=4.5mmol/l had no increased mean birth-weight or macrosomia (>/=4500g) compared to 
      controls. In the follow up 334/1324 women (25%) of the GDM women had developed 
      diabetes, 215 type 2 diabetes, 46 type 1 diabetes and 72 unclassified diabetes. 
      In logistic regression fasting cB-glucose and 2h OGTT cB-glucose at diagnosis of 
      GDM as well as BMI >25 and origin outside Europe were risk factors for manifest 
      diabetes. CONCLUSIONS: Fasting blood glucose at diagnosis of GDM gives important 
      information besides 2h OGTT glucose about pregnancy outcome and future risk for 
      maternal diabetes.
CI  - Copyright (c) 2016 Elsevier Ireland Ltd. All rights reserved.
FAU - Wahlberg, Jeanette
AU  - Wahlberg J
AD  - Department of Endocrinology and Department of Medical and Health Sciences, 
      Linkoping University, Linkoping, Sweden; Department of Endocrinology and 
      Department of Clinical and Experimental Medicine, Linkoping University, 
      Linkoping, Sweden.
FAU - Ekman, Bertil
AU  - Ekman B
AD  - Department of Endocrinology and Department of Medical and Health Sciences, 
      Linkoping University, Linkoping, Sweden.
FAU - Nystrom, Lennarth
AU  - Nystrom L
AD  - Department of Public Health and Clinical Medicine, Epidemiology, Umea University, 
      Umea, Sweden.
FAU - Hanson, Ulf
AU  - Hanson U
AD  - Department of Women's and Children's Health, University of Uppsala, Uppsala, 
      Sweden.
FAU - Persson, Bengt
AU  - Persson B
AD  - Department of Women and Child Health Division of Pediatrics, Karolinska 
      Institute, Stockholm, Sweden.
FAU - Arnqvist, Hans J
AU  - Arnqvist HJ
AD  - Department of Endocrinology and Department of Clinical and Experimental Medicine, 
      Linkoping University, Linkoping, Sweden. Electronic address: 
      hans.arnqvist@liu.se.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160112
PL  - Ireland
TA  - Diabetes Res Clin Pract
JT  - Diabetes research and clinical practice
JID - 8508335
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Adult
MH  - Birth Weight
MH  - Blood Glucose/*analysis
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/blood/*diagnosis/etiology
MH  - Diabetes, Gestational/blood/*physiopathology
MH  - Fasting/blood
MH  - Female
MH  - Fetal Macrosomia/blood/*diagnosis/etiology
MH  - Gestational Age
MH  - Glucose Tolerance Test
MH  - Humans
MH  - Logistic Models
MH  - Pregnancy
MH  - *Pregnancy Outcome
MH  - Prospective Studies
MH  - Risk Factors
OTO - NOTNLM
OT  - Birth weight
OT  - Blood glucose
OT  - GDM
OT  - OGTT
OT  - Pregnancy
EDAT- 2016/01/29 06:00
MHDA- 2016/12/15 06:00
CRDT- 2016/01/29 06:00
PHST- 2015/07/18 00:00 [received]
PHST- 2015/11/23 00:00 [revised]
PHST- 2015/12/28 00:00 [accepted]
PHST- 2016/01/29 06:00 [entrez]
PHST- 2016/01/29 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
AID - S0168-8227(16)00023-1 [pii]
AID - 10.1016/j.diabres.2015.12.017 [doi]
PST - ppublish
SO  - Diabetes Res Clin Pract. 2016 Apr;114:99-105. doi: 10.1016/j.diabres.2015.12.017. 
      Epub 2016 Jan 12.