PMID- 26819793
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160128
LR  - 20200930
IS  - 2090-6781 (Print)
IS  - 2090-679X (Electronic)
IS  - 2090-679X (Linking)
VI  - 2015
DP  - 2015
TI  - Isolated Ocular Manifestation of Relapsed Chronic Myelogenous Leukemia Presenting 
      as Myeloid Blast Crisis in a Patient on Imatinib Therapy: A Case Report and 
      Review of the Literature.
PG  - 380451
LID - 10.1155/2015/380451 [doi]
LID - 380451
AB  - Blast phase in chronic myelogenous leukemia (CML) has rarely been reported to 
      involve extramedullary sites like skin, lymph nodes, and central nervous system. 
      Clinical history, characteristic hematologic findings (elevated leukocyte counts, 
      myelocytic predominance, and basophilia), and Philadelphia chromosome are of high 
      diagnostic significance especially in isolated extramedullary presentations. We 
      describe a unique case of CML relapse with blast phase involving the eye. A 
      66-year-old man with a known diagnosis of CML on imatinib and in molecular 
      remission for 3 years presented with a painful blind eye. Histologic examination 
      revealed diffuse involvement of choroid, iris, vitreous humor, and the optic 
      nerve by blast cells. The blasts expressed CD34, aberrant TdT, and a myeloid 
      phenotype (CD13, CD33, and CD117). Fluorescence in situ hybridization (FISH) of 
      vitreous fluid detected BCR-ABL1 gene rearrangement. Additionally, trisomy 8 and 
      gains of 9 and 22 were seen which were not present in the initial diagnostic 
      marrow study 3 years ago. At relapse, the bone marrow, peripheral blood, and the 
      cerebrospinal fluid were not involved by CML. Patient received induction 
      chemotherapy and single dose prophylactic intrathecal methotrexate and was 
      maintained on antityrosine kinase therapy and eventually underwent allogenic stem 
      cell transplantation.
FAU - Gulati, Rohit
AU  - Gulati R
AD  - Henry Ford Hospital, 2799 W. Grand Boulevard, Detroit, MI 48202, USA.
FAU - Alkhatib, Yaser
AU  - Alkhatib Y
AD  - Henry Ford Hospital, 2799 W. Grand Boulevard, Detroit, MI 48202, USA.
FAU - Donthireddy, Vijayalakshmi
AU  - Donthireddy V
AD  - Henry Ford Hospital, 2799 W. Grand Boulevard, Detroit, MI 48202, USA.
FAU - Felicella, Michelle Madden
AU  - Felicella MM
AD  - Henry Ford Hospital, 2799 W. Grand Boulevard, Detroit, MI 48202, USA.
FAU - Menon, Madhu P
AU  - Menon MP
AD  - Henry Ford Hospital, 2799 W. Grand Boulevard, Detroit, MI 48202, USA.
FAU - Inamdar, Kedar V
AU  - Inamdar KV
AD  - Henry Ford Hospital, 2799 W. Grand Boulevard, Detroit, MI 48202, USA.
LA  - eng
PT  - Journal Article
DEP - 20151224
PL  - United States
TA  - Case Rep Pathol
JT  - Case reports in pathology
JID - 101576609
PMC - PMC4706875
EDAT- 2016/01/29 06:00
MHDA- 2016/01/29 06:01
PMCR- 2015/12/24
CRDT- 2016/01/29 06:00
PHST- 2015/09/29 00:00 [received]
PHST- 2015/11/10 00:00 [revised]
PHST- 2015/11/30 00:00 [accepted]
PHST- 2016/01/29 06:00 [entrez]
PHST- 2016/01/29 06:00 [pubmed]
PHST- 2016/01/29 06:01 [medline]
PHST- 2015/12/24 00:00 [pmc-release]
AID - 10.1155/2015/380451 [doi]
PST - ppublish
SO  - Case Rep Pathol. 2015;2015:380451. doi: 10.1155/2015/380451. Epub 2015 Dec 24.