PMID- 26819904
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160128
LR  - 20201001
IS  - 2187-137X (Print)
IS  - 2186-5116 (Electronic)
IS  - 2186-5116 (Linking)
VI  - 3
IP  - Spec Issue
DP  - 2014
TI  - Increasing the Performance of Portable Ion Mobility Analyzers: Development of the 
      Periodic Focusing Differential Mobility Analyzer (PFDMA).
PG  - S0032
LID - 10.5702/massspectrometry.S0032 [doi]
LID - S0032
AB  - Ion mobility spectrometry (IMS) as a stand-alone technique has become 
      increasingly important for applications in security, defense, and environmental 
      monitoring, and also in biological applications such as molecular structure and 
      -omic analysis when combined with mass spectrometry. Yet, the majority of these 
      devices are drift cell based and limited by low duty cycles because of ion 
      gating. Differential Mobility Analyzers (DMAs) are attractive alternatives due to 
      their continuous ion transmission and success in analyzing aerosol particles in 
      real time environmental tests. But, the resolution of a DMA is low due to 
      difficulties in achieving laminar gas flow, low sample gas flow to sheath gas 
      flow ratio, and high velocity sheath gas using small pumps, if portability is a 
      concern. To overcome these challenges, we will introduce a new ion mobility 
      spectrometer that increases the amount of work done on the ions during separation 
      by introducing an electric field opposing the gas flow direction while 
      simultaneously preserving laminar gas flow. The development of the Periodic 
      Focusing Differential Mobility Analyzer (PFDMA) can lead to a portable device 
      that exhibits both high resolution and sensitivity, to meet the needs of today's 
      expanding applications.
FAU - Gillig, Kent J
AU  - Gillig KJ
AD  - Genomics Research Center, Academia Sinica.
FAU - Chen, Chung-Hsuan
AU  - Chen CH
AD  - Genomics Research Center, Academia Sinica.
LA  - eng
PT  - Journal Article
DEP - 20140501
PL  - Japan
TA  - Mass Spectrom (Tokyo)
JT  - Mass spectrometry (Tokyo, Japan)
JID - 101603453
PMC - PMC4541064
OTO - NOTNLM
OT  - differential mobility analyzer
OT  - ion mobility spectrometry
OT  - mass spectrometry
EDAT- 2014/01/01 00:00
MHDA- 2014/01/01 00:01
PMCR- 2014/05/01
CRDT- 2016/01/29 06:00
PHST- 2013/09/12 00:00 [received]
PHST- 2014/01/21 00:00 [accepted]
PHST- 2016/01/29 06:00 [entrez]
PHST- 2014/01/01 00:00 [pubmed]
PHST- 2014/01/01 00:01 [medline]
PHST- 2014/05/01 00:00 [pmc-release]
AID - 10.5702/massspectrometry.S0032 [doi]
PST - ppublish
SO  - Mass Spectrom (Tokyo). 2014;3(Spec Issue):S0032. doi: 
      10.5702/massspectrometry.S0032. Epub 2014 May 1.