PMID- 26820588
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20191210
IS  - 1939-0084 (Electronic)
IS  - 0735-7044 (Linking)
VI  - 130
IP  - 2
DP  - 2016 Apr
TI  - The effect of MDMA on sensitivity to reinforcement rate.
PG  - 243-51
LID - 10.1037/bne0000125 [doi]
AB  - Administration of (+/-)3,4-methylenedioxymethamphetamine (MDMA) causes memory 
      errors by increasing proactive interference. This might occur because MDMA alters 
      sensitivity to reinforcement. The current 2 experiments investigated this 
      directly by assessing the acute (Experiment 1) and chronic (Experiment 2) effects 
      of MDMA on sensitivity to reinforcement. We presented 5 pairs of concurrent 
      variable interval schedules within each session and calculated sensitivity to 
      reinforcement for 3 acute doses of MDMA. In contrast to the related drug, 
      d-amphetamine, and in spite of producing reductions in response rate, MDMA did 
      not reduce sensitivity to reinforcement rate. Chronic administration of a fixed 
      dose of MDMA following each session reduced response rate but did not affect 
      sensitivity to reinforcement rate. In combination with previous research, these 
      results indicate that related drugs may have different effects on sensitivity to 
      reinforcement and that these effects should be considered when interpreting 
      disruptions to operant task performance caused by drug administration. (PsycINFO 
      Database Record
CI  - (c) 2016 APA, all rights reserved).
FAU - Lie, Celia
AU  - Lie C
AD  - Department of Psychology.
FAU - Macaskill, Anne C
AU  - Macaskill AC
AD  - School of Psychology.
FAU - Harper, David N
AU  - Harper DN
AD  - School of Psychology.
LA  - eng
PT  - Journal Article
DEP - 20160128
PL  - United States
TA  - Behav Neurosci
JT  - Behavioral neuroscience
JID - 8302411
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - TZ47U051FI (Dextroamphetamine)
SB  - IM
MH  - Animals
MH  - Conditioning, Operant/drug effects
MH  - Dextroamphetamine
MH  - Dose-Response Relationship, Drug
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Rats
MH  - Reinforcement Schedule
MH  - Reinforcement, Psychology
EDAT- 2016/01/29 06:00
MHDA- 2016/12/15 06:00
CRDT- 2016/01/29 06:00
PHST- 2016/01/29 06:00 [entrez]
PHST- 2016/01/29 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
AID - 2016-04497-001 [pii]
AID - 10.1037/bne0000125 [doi]
PST - ppublish
SO  - Behav Neurosci. 2016 Apr;130(2):243-51. doi: 10.1037/bne0000125. Epub 2016 Jan 
      28.