PMID- 26821688
OWN - NLM
STAT- MEDLINE
DCOM- 20161114
LR  - 20161230
IS  - 1347-4820 (Electronic)
IS  - 1346-9843 (Linking)
VI  - 80
IP  - 3
DP  - 2016
TI  - Outcome of Patients Treated by Cardiac Resynchronization Therapy Using a 
      Quadripolar Left Ventricular Lead.
PG  - 613-8
LID - 10.1253/circj.CJ-15-0932 [doi]
AB  - BACKGROUND: Not all heart failure (HF) patients benefit from cardiac 
      resynchronization therapy (CRT). We assessed whether choosing the site of left 
      ventricular (LV) pacing by a quadripolar lead may improve response to CRT. 
      METHODS AND RESULTS: We prospectively randomized 23 patients with HF (67+/-11 
      years; 21 males) to CRT with a quadripolar LV lead (group 1, with the LV pacing 
      site chosen on the basis of QRS shortening using simultaneous biventricular 
      pacing), and 20 patients (71+/-6 years; 16 males) to a bipolar LV lead (group 2, 
      with devices programmed with a conventional tip-to-ring configuration). New York 
      Heart Association (NYHA) class and LV ejection fraction (EF) by 2D 
      echocardiography were assessed at baseline and after 3 months. The baseline EF 
      was not different between the 2 groups (25+/-6% group 1 vs. 27+/-3% group 2; P=0.22), 
      but after 3 months EF was higher in group 1 (35+/-13% group 1 vs. 31+/-4% group 2; 
      P<0.001). A reduction in at least 1 NYHA class at 3 months was observed in 22 
      (96%) and 12 (60%) of group 1 and group 2 patients, respectively (P<0.05). 
      CONCLUSIONS: CRT with a quadripolar LV lead was associated with an improvement of 
      EF greater than that observed in patients receiving a bipolar LV lead. In devices 
      with a quadripolar lead, CRT programming based on the best QRS shortening is 
      reliable and effective. (Circ J 2016; 80: 613-618).
FAU - Bencardino, Gianluigi
AU  - Bencardino G
AD  - Department of Cardiovascular Medicine, Catholic University of the Sacred Heart.
FAU - Di Monaco, Antonio
AU  - Di Monaco A
FAU - Russo, Eleonora
AU  - Russo E
FAU - Colizzi, Cristian
AU  - Colizzi C
FAU - Perna, Francesco
AU  - Perna F
FAU - Pelargonio, Gemma
AU  - Pelargonio G
FAU - Narducci, Maria Lucia
AU  - Narducci ML
FAU - Gabrielli, Francesca Augusta
AU  - Gabrielli FA
FAU - Lanza, Gaetano Antonio
AU  - Lanza GA
FAU - Rebuzzi, Antonio Giuseppe
AU  - Rebuzzi AG
FAU - Crea, Filippo
AU  - Crea F
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20160129
PL  - Japan
TA  - Circ J
JT  - Circulation journal : official journal of the Japanese Circulation Society
JID - 101137683
SB  - IM
MH  - Aged
MH  - Cardiac Resynchronization Therapy/*methods
MH  - Female
MH  - Heart Failure/*physiopathology/*therapy
MH  - Heart Ventricles/physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
EDAT- 2016/01/30 06:00
MHDA- 2016/11/15 06:00
CRDT- 2016/01/30 06:00
PHST- 2016/01/30 06:00 [entrez]
PHST- 2016/01/30 06:00 [pubmed]
PHST- 2016/11/15 06:00 [medline]
AID - 10.1253/circj.CJ-15-0932 [doi]
PST - ppublish
SO  - Circ J. 2016;80(3):613-8. doi: 10.1253/circj.CJ-15-0932. Epub 2016 Jan 29.