PMID- 26821843
OWN - NLM
STAT- MEDLINE
DCOM- 20161025
LR  - 20211203
IS  - 1029-2330 (Electronic)
IS  - 1026-7158 (Linking)
VI  - 24
IP  - 4
DP  - 2016
TI  - Angelica sinensis reduced Abeta-induced memory impairment in rats.
PG  - 340-7
LID - 10.3109/1061186X.2015.1077848 [doi]
AB  - BACKGROUND: Studies have shown that Angelica sinensis (JiLin AoDong Medicine 
      Industry Groups Co., Ltd., Jilin, China) root (AS) ameliorates various diseases, 
      although its effects in Alzheimer's disease (AD) have not been elucidated. 
      PURPOSE: The present study examined the effects of AS in a rat model of AD. 
      METHODS: Positional Abeta injections were administered to rats. The behavioral 
      effects of AS administration were examined using the Morris water maze, and the 
      molecular effects on gene and protein expression, and apoptosis, were determined. 
      RESULTS: AS reversed the social behavioral impairments observed in this rat model 
      of Abeta-induced memory impairment. Western blot analysis also revealed lower 
      hippocampal levels of Abeta and beta-site amyloid precursor protein-cleaving enzyme. 
      Terminal deoxynucleotidyl transferased UTP nick end labeling indicated that AS 
      significantly inhibited apoptosis via effects on nuclear factor kappa B (NF-kappaB) 
      signaling. Real-time PCR, enzyme-linked immunosorbent assay, and 
      immunohistochemical staining indicated that AS effectively inhibited inflammation 
      and upregulated expression of glial cell line-derived neurotrophic factor (GDNF) 
      and brain-derived neurotrophic factor (BDNF) in the hippocampus of this rat AD 
      model. DISCUSSION: AS effectively rescued the symptoms of AD in a rat model by 
      inhibiting inflammation, apoptosis, and NF-kappaB signaling pathway. CONCLUSION: 
      These findings suggested that AS could provide a potential drug for the treatment 
      of AD.
FAU - Duan, Ming-Hua
AU  - Duan MH
AD  - a Changchun University of Chinese Medicine , Changchun , China.
FAU - Wang, Li-Na
AU  - Wang LN
AD  - a Changchun University of Chinese Medicine , Changchun , China.
FAU - Jiang, Yan-Hong
AU  - Jiang YH
AD  - a Changchun University of Chinese Medicine , Changchun , China.
FAU - Pei, Ying-Yuan
AU  - Pei YY
AD  - a Changchun University of Chinese Medicine , Changchun , China.
FAU - Guan, Dong-Dong
AU  - Guan DD
AD  - a Changchun University of Chinese Medicine , Changchun , China.
FAU - Qiu, Zhi-Dong
AU  - Qiu ZD
AD  - a Changchun University of Chinese Medicine , Changchun , China.
LA  - eng
PT  - Journal Article
DEP - 20150907
PL  - England
TA  - J Drug Target
JT  - Journal of drug targeting
JID - 9312476
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Drugs, Chinese Herbal)
RN  - B66F4574UG (angelicae sinensis extract)
RN  - EC 3.4.- (Amyloid Precursor Protein Secretases)
RN  - EC 3.4.23.- (Aspartic Acid Endopeptidases)
RN  - EC 3.4.23.46 (Bace1 protein, rat)
SB  - IM
MH  - Alzheimer Disease/*drug therapy/metabolism/pathology
MH  - Amyloid Precursor Protein Secretases/metabolism
MH  - Amyloid beta-Peptides/administration & dosage/*metabolism
MH  - Angelica sinensis
MH  - Animals
MH  - Apoptosis/drug effects
MH  - Aspartic Acid Endopeptidases/metabolism
MH  - Behavior, Animal/drug effects
MH  - Disease Models, Animal
MH  - Drugs, Chinese Herbal/administration & dosage/*therapeutic use
MH  - Hippocampus/drug effects/metabolism/pathology
MH  - Male
MH  - Maze Learning/drug effects
MH  - Rats, Wistar
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - apoptosis
OT  - inflammation
OT  - nuclear factor kappa B signaling pathway
OT  - radix Angelica sinensis
EDAT- 2016/01/30 06:00
MHDA- 2016/10/26 06:00
CRDT- 2016/01/30 06:00
PHST- 2016/01/30 06:00 [entrez]
PHST- 2016/01/30 06:00 [pubmed]
PHST- 2016/10/26 06:00 [medline]
AID - 10.3109/1061186X.2015.1077848 [doi]
PST - ppublish
SO  - J Drug Target. 2016;24(4):340-7. doi: 10.3109/1061186X.2015.1077848. Epub 2015 
      Sep 7.